Publications by authors named "Asako Harada"

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Antitumor Cytotoxic Activity Retained in Tolerized T Cells Following Daily Dose Escalation of a T-Cell Engager in Cynomolgus Monkeys to Mitigate Cytokine Release Syndrome.
Yoshika Iwata, Tomochika Matsushita, Yuta Narushima, Asako Harada, Yuichiro Sakamoto

J Appl Toxicol· September 2025

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Preclinical in vitro evaluation of immune suppression induced by GYM329, Fc-engineered sweeping antibody.
Yoshika Iwata, Hitoshi Katada, Momoko Okuda, Yoshiaki Doi, Tim Jang Ching, Asako Harada

J Toxicol Sci· November 2023

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Priming treatment with T-cell redirecting bispecific antibody ERY974 reduced cytokine induction without losing cytotoxic activity in vitro by changing the chromatin state in T cells.
Yoshika Iwata, Yuta Narushima, Asako Harada, Masayuki Mishima

Toxicol Appl Pharmacol· April 2022

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In vitro toxicological support to establish specification limit for anti-CD3 monospecific impurity in a bispecific T cell engager drug, ERY974.
Asako Harada, Akifumi Shioda, Tatsuya Ikuno, Yoshika Iwata, Hirotake Shiraiwa

Toxicol In Vitro· August 2020

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Daily ascending dosing in cynomolgus monkeys to mitigate cytokine release syndrome induced by ERY22, surrogate for T-cell redirecting bispecific antibody ERY974 for cancer immunotherapy.
Yoshika Iwata, Masanori Sasaki, Asako Harada, Junko Taketo, Toshiko Hara

Toxicol Appl Pharmacol· September 2019

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High-content imaging analyses of γH2AX-foci and micronuclei in TK6 cells elucidated genotoxicity of chemicals and their clastogenic/aneugenic mode of action.
Akira Takeiri, Kaori Matsuzaki, Shigeki Motoyama, Mariko Yano, Asako Harada

Genes Environ· February 2019

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Different players generate positive responses in two in vitro cytokine assay formats with aqueous and immobilized TGN1412 analog.
Yoshika Iwata, Asako Harada, Chiyomi Kubo, Tomoaki Inoue, Mitsuyasu Tabo

Biochem Biophys Res Commun· July 2018

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Advantages of evaluating γH2AX induction in non-clinical drug development.
Shigeki Motoyama, Akira Takeiri, Kenji Tanaka, Asako Harada, Kaori Matsuzaki

Genes Environ· May 2018

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An anti-glypican 3/CD3 bispecific T cell-redirecting antibody for treatment of solid tumors.
Takahiro Ishiguro, Yuji Sano, Shun-Ichiro Komatsu, Mika Kamata-Sakurai, Akihisa Kaneko, Asako Harada

Sci Transl Med· October 2017

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Giemsa-stained pseudo-micronuclei in rat skin treated with vitamin D analog, pefcalcitol.
Akira Takeiri, Kenji Tanaka, Asako Harada, Kaori Matsuzaki, Mariko Yano

Genes Environ· June 2017

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Is an in vitro whole blood cytokine assay useful to detect the potential risk of severe infusion reaction of monoclonal antibody pharmaceuticals?
Yoshika Iwata, Asako Harada, Toshiko Hara, Chiyomi Kubo, Tomoaki Inoue

J Toxicol Sci· April 2017

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HSP90 inhibitor CH5164840 induces micronuclei in TK6 cells via an aneugenic mechanism.
Kaori Matsuzaki, Asako Harada, Kenji Tanaka, Akira Takeiri, Masayuki Mishima

Mutat Res Genet Toxicol Environ Mutagen· October 2014

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The predominant role of apoptosis in γH2AX formation induced by aneugens is useful for distinguishing aneugens from clastogens.
Asako Harada, Kaori Matsuzaki, Akira Takeiri, Masayuki Mishima

Mutat Res Genet Toxicol Environ Mutagen· September 2014

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New DNA probes to detect aneugenicity in rat bone marrow micronucleated cells by a pan-centromeric FISH analysis.
Akira Takeiri, Shigeki Motoyama, Kaori Matsuzaki, Asako Harada, Junko Taketo

Mutat Res· July 2013

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Fluorescent dye-based simple staining for in vivo micronucleus test with flow cytometer.
Asako Harada, Kaori Matsuzaki, Akira Takeiri, Kenji Tanaka, Masayuki Mishima

Mutat Res· March 2013

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Whole cell-ELISA to measure the gammaH2AX response of six aneugens and eight DNA-damaging chemicals.
Kaori Matsuzaki, Asako Harada, Akira Takeiri, Kenji Tanaka, Masayuki Mishima

Mutat Res· July 2010

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Two structurally distinct inhibitors of glycogen synthase kinase 3 induced centromere positive micronuclei in human lymphoblastoid TK6 cells.
Masayuki Mishima, Kenji Tanaka, Akira Takeiri, Asako Harada, Chiyomi Kubo

Mutat Res· August 2008

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A newly established GDL1 cell line from gpt delta mice well reflects the in vivo mutation spectra induced by mitomycin C.
Akira Takeiri, Masayuki Mishima, Kenji Tanaka, Akifumi Shioda, Asako Harada

Mutat Res· October 2006

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