Publications by authors named "Ashutosh Dhingra"

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Chr:17q21.31 locus risk haplotype H1 susceptibility to ferroptosis is mediated by endolysosomal pathway.
Eldem Sadikoglou, Daniel Domingo-Fernández, Natalia Savytska, Noemia Fernandes, Patrizia Rizzu, Ashutosh Dhingra

Cell Death Dis· November 2025

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Frontotemporal dementia patient-derived iPSC neurons show cell pathological hallmarks and evidence for synaptic dysfunction and DNA damage.
Nadine Huber, Tomi Hietanen, Sami Heikkinen, Anastasia Shakirzyanova, Dorit Hoffmann, Ashutosh Dhingra

Mol Psychiatry· September 2025

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Correction of dysregulated lipid metabolism normalizes gene expression in oligodendrocytes and prolongs lifespan in female poly-GA C9orf72 mice.
Ali Rezaei, Virág Kocsis-Jutka, Zeynep I Gunes, Qing Zeng, Georg Kislinger, Ashutosh Dhingra

Nat Commun· April 2025

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Arrayed CRISPR libraries for the genome-wide activation, deletion and silencing of human protein-coding genes.
Jiang-An Yin, Lukas Frick, Manuel C Scheidmann, Tingting Liu, Chiara Trevisan, Ashutosh Dhingra

Nat Biomed Eng· January 2025

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Direct and indirect regulation of β-glucocerebrosidase by the transcription factors USF2 and ONECUT2.
Kathi Ging, Lukas Frick, Johannes Schlachetzki, Andrea Armani, Yanping Zhu, Ashutosh Dhingra

NPJ Parkinsons Dis· October 2024

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A multi-omics dataset for the analysis of frontotemporal dementia genetic subtypes.
Kevin Menden, Margherita Francescatto, Tenzin Nyima, Cornelis Blauwendraat, Ashutosh Dhingra

Sci Data· December 2023

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Drug screen in iPSC-Neurons identifies nucleoside analogs as inhibitors of (GC) expression in C9orf72 ALS/FTD.
Mareike Czuppa, Ashutosh Dhingra, Qihui Zhou, Carina Schludi, Laura König

Cell Rep· June 2022

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Novel regulators of PrPC biosynthesis revealed by genome-wide RNA interference.
Daniel Heinzer, Merve Avar, Daniel Patrick Pease, Ashutosh Dhingra, Jiang-An Yin

PLoS Pathog· October 2021

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iPS Cell-Based Model for Haplotype as a Risk Factor for Human Tauopathies Identifies No Major Differences in TAU Expression.
Tabea Strauß, Amir Marvian-Tayaranian, Eldem Sadikoglou, Ashutosh Dhingra, Florian Wegner

Front Cell Dev Biol· August 2021

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Concomitant gain and loss of function pathomechanisms in C9ORF72 amyotrophic lateral sclerosis.
Arun Pal, Benedikt Kretner, Masin Abo-Rady, Hannes Glaβ, Banaja P Dash, Ashutosh Dhingra

Life Sci Alliance· April 2021

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Automated Production of Human Induced Pluripotent Stem Cell-Derived Cortical and Dopaminergic Neurons with Integrated Live-Cell Monitoring.
Ashutosh Dhingra, Joachim Täger, Elisangela Bressan, Salvador Rodriguez-Nieto, Manmeet-Sakshi Bedi

J Vis Exp· August 2020

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In Vitro Differentiated Human Stem Cell-Derived Neurons Reproduce Synaptic Synchronicity Arising during Neurodevelopment.
Filip Rosa, Ashutosh Dhingra, Betül Uysal, G Dulini C Mendis, Heidi Loeffler

Stem Cell Reports· July 2020

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A Pentanucleotide ATTTC Repeat Insertion in the Non-coding Region of DAB1, Mapping to SCA37, Causes Spinocerebellar Ataxia.
Ana I Seixas, Joana R Loureiro, Cristina Costa, Andrés Ordóñez-Ugalde, Hugo Marcelino, Ashutosh Dhingra

Am J Hum Genet· July 2017

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C9orf72 is differentially expressed in the central nervous system and myeloid cells and consistently reduced in C9orf72, MAPT and GRN mutation carriers.
Patrizia Rizzu, Cornelis Blauwendraat, Sasja Heetveld, Emily M Lynes, Melissa Castillo-Lizardo, Ashutosh Dhingra

Acta Neuropathol Commun· April 2016

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Genetic correction of a LRRK2 mutation in human iPSCs links parkinsonian neurodegeneration to ERK-dependent changes in gene expression.
Peter Reinhardt, Benjamin Schmid, Lena F Burbulla, David C Schöndorf, Lydia Wagner, Ashutosh Dhingra

Cell Stem Cell· March 2013

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