Publications by authors named "Ashwinkumar Bhirde"

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Innovative approach to support therapeutic proteins' similarity in hydrodynamic size using high-throughput dynamic light scattering and forced degradation.
Ashwinkumar Bhirde, Siri Harish, Nicholas Trunfio, Isabella F de Luna, William Smith

Sci Rep· November 2025

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Root cause analysis investigation of visible particulates in therapeutic protein drug products using morphologically directed Raman spectroscopy.
Isabella F de Luna, Srivalli N Telikepalli, Michael Carrier, Dean Ripple, Charudharshini Srinivasan, Ashwinkumar Bhirde

Sci Rep· November 2025

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Morphologically-Directed Raman Spectroscopy as an Analytical Method for Subvisible Particle Characterization in Therapeutic Protein Product Quality.
Minkyung Kim, Youlong Ma, Charudharshini Srinivasan, Thomas O'Connor, Srivalli N Telikepalli, Ashwinkumar Bhirde

Sci Rep· November 2023

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An Interlaboratory Study to Identify Potential Visible Protein-Like Particle Standards.
Srivalli N Telikepalli, Michael J Carrier, Dean C Ripple, Greg Barnett, Ashwinkumar Bhirde

AAPS PharmSciTech· December 2022

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Failure Mode Identification of Insulin Drug Products - Impact of Relevant Stress Conditions on the Quality of the Drug.
Minkyung Kim, Bhaskara Vijaya Chikkaveeraiah, Drishti Maniar, Brian Roelofs, Muthukumar Ramaswamy, Ashwinkumar Bhirde

J Pharm Sci· September 2022

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An Interlaboratory Comparison on the Characterization of a Sub-micrometer Polydisperse Particle Dispersion.
Kurt D Benkstein, Gurusamy Balakrishnan, Ashwinkumar Bhirde, Pascal Chalus, Tapan K Das

J Pharm Sci· March 2022

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High Performance Size Exclusion Chromatography and High-Throughput Dynamic Light Scattering as Orthogonal Methods to Screen for Aggregation and Stability of Monoclonal Antibody Drug Products.
Ashwinkumar Bhirde, Bhaskara Vijaya Chikkaveeraiah, Ramesh Venna, Rachel Carley, Kurt Brorson

J Pharm Sci· November 2020

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The ELISA Detectability and Potency of Pegfilgrastim Decrease in Physiological Conditions: Key Roles for Aggregation and Individual Variability.
Tao Xie, Hui Fang, Weiming Ouyang, Phillip Angart, Meng-Jung Chiang, Ashwinkumar A Bhirde

Sci Rep· February 2020

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High-Throughput In-Use and Stress Size Stability Screening of Protein Therapeutics Using Algorithm-Driven Dynamic Light Scattering.
Ashwinkumar A Bhirde, Meng-Jung Chiang, Ramesh Venna, Serge Beaucage, Kurt Brorson

J Pharm Sci· August 2018

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Structural evaluation of an amyloid fibril model using small-angle x-ray scattering.
Eshan Dahal, Mina Choi, Nadia Alam, Ashwinkumar A Bhirde, Serge L Beaucage

Phys Biol· June 2017

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Algorithm-driven high-throughput screening of colloidal nanoparticles under simulated physiological and therapeutic conditions.
Ashwinkumar A Bhirde, Sivasish Sindiri, Gina N Calco, Maria A Aronova, Serge L Beaucage

Nanoscale· February 2017

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Photosensitizer loaded nano-graphene for multimodality imaging guided tumor photodynamic therapy.
Pengfei Rong, Kai Yang, Avinash Srivastan, Dale O Kiesewetter, Xuyi Yue, Ashwinkumar Bhirde

Theranostics· October 2014

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Carbon-dot-based two-photon visible nanocarriers for safe and highly efficient delivery of siRNA and DNA.
Liqin Wang, Xiaoyong Wang, Ashwinkumar Bhirde, Jianbo Cao, Yun Zeng

Adv Healthc Mater· August 2014

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Role of Albumin in the Formation and Stabilization of Nanoparticle Aggregates in Serum Studied by Continuous Photon Correlation Spectroscopy and Multiscale Computer Simulations.
Ashwinkumar A Bhirde, Sergio A Hassan, Erick Harr, Xiaoyuan Chen

J Phys Chem C Nanomater Interfaces· July 2014

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Targeted therapeutic nanotubes influence the viscoelasticity of cancer cells to overcome drug resistance.
Ashwinkumar A Bhirde, Bhaskara V Chikkaveeraiah, Avinash Srivatsan, Gang Niu, Albert J Jin

ACS Nano· May 2014

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Highly robust, recyclable displacement assay for mercuric ions in aqueous solutions and living cells.
Dingbin Liu, Shouju Wang, Magdalena Swierczewska, Xinglu Huang, Ashwinkumar A Bhirde

ACS Nano· December 2012

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A nanoscale graphene oxide-peptide biosensor for real-time specific biomarker detection on the cell surface.
Zhe Wang, Peng Huang, Ashwinkumar Bhirde, Albert Jin, Ying Ma

Chem Commun (Camb)· October 2012

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Electrochemical immunosensors for detection of cancer protein biomarkers.
Bhaskara V Chikkaveeraiah, Ashwinkumar A Bhirde, Nicole Y Morgan, Henry S Eden, Xiaoyuan Chen

ACS Nano· August 2012

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A facile, one-step nanocarbon functionalization for biomedical applications.
Magdalena Swierczewska, Ki Young Choi, Edward L Mertz, Xinglu Huang, Fan Zhang, Ashwinkumar Bhirde

Nano Lett· July 2012

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Nuclear mapping of nanodrug delivery systems in dynamic cellular environments.
Ashwinkumar A Bhirde, Ankur Kapoor, Gang Liu, Ramiro Iglesias-Bartolome, Albert Jin

ACS Nano· June 2012

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Multiplex imaging of an intracellular proteolytic cascade by using a broad-spectrum nanoquencher.
Xinglu Huang, Magdalena Swierczewska, Ki Young Choi, Lei Zhu, Ashwinkumar Bhirde

Angew Chem Int Ed Engl· February 2012

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Sticky nanoparticles: a platform for siRNA delivery by a bis(zinc(II) dipicolylamine)-functionalized, self-assembled nanoconjugate.
Gang Liu, Ki Young Choi, Ashwinkumar Bhirde, Magdalena Swierczewska, Juan Yin

Angew Chem Int Ed Engl· January 2012

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Polyaspartic acid coated manganese oxide nanoparticles for efficient liver MRI.
Ruijun Xing, Fan Zhang, Jin Xie, Maria Aronova, Guofeng Zhang, Ashwinkumar Bhirde

Nanoscale· December 2011

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Combining portable Raman probes with nanotubes for theranostic applications.
Ashwinkumar A Bhirde, Gang Liu, Albert Jin, Ramiro Iglesias-Bartolome, Alioscka A Sousa

Theranostics· November 2011

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Functional MnO nanoclusters for efficient siRNA delivery.
Ruijun Xing, Gang Liu, Qimeng Quan, Ashwinkumar Bhirde, Guofeng Zhang

Chem Commun (Camb)· November 2011

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