Publications by authors named "Assunta Cirella"

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Interleukin-18 in cancer immunology and immunotherapy.
Assunta Cirella, Irene Olivera, Carlos Luri-Rey, Elixabet Bolaños, Pedro Berraondo

Expert Opin Ther Targets· December 2023

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Intratumoral co-injection of NK cells and NKG2A-neutralizing monoclonal antibodies.
Ignacio Melero, Maria C Ochoa, Carmen Molina, Sandra Sanchez-Gregorio, Saray Garasa, Assunta Cirella

EMBO Mol Med· November 2023

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Intraperitoneal administration of a modified vaccinia virus Ankara confers single-chain interleukin-12 expression to the omentum and achieves immune-mediated efficacy against peritoneal carcinomatosis.
Ángela Bella, Leire Arrizabalaga, Claudia Augusta Di Trani, Jose Gonzalez-Gomariz, Celia Gomar, Assunta Cirella

J Immunother Cancer· November 2023

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Intratumoral injection of IL-12-encoding mRNA targeted to CSFR1 and PD-L1 exerts potent anti-tumor effects without substantial systemic exposure.
Claudia Augusta Di Trani, Assunta Cirella, Leire Arrizabalaga, Maite Alvarez, Ángela Bella

Mol Ther Nucleic Acids· September 2023

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Intratumoral immunotherapy with mRNAs encoding chimeric protein constructs encompassing IL-12, CD137 agonists, and TGF-β antagonists.
Assunta Cirella, Elixabet Bolaños, Carlos Luri-Rey, Claudia Augusta Di Trani, Irene Olivera

Mol Ther Nucleic Acids· September 2023

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Intratumoral neoadjuvant immunotherapy based on the BO-112 viral RNA mimetic.
Maite Alvarez, Carmen Molina, Saray Garasa, Maria C Ochoa, Maria E Rodriguez-Ruiz, Assunta Cirella

Oncoimmunology· April 2023

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Synergistic effects of combined immunotherapy strategies in a model of multifocal hepatocellular carcinoma.
Maria Carmen Ochoa, Sandra Sanchez-Gregorio, Carlos E de Andrea, Saray Garasa, Maite Alvarez, Assunta Cirella

Cell Rep Med· April 2023

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mRNAs encoding IL-12 and a decoy-resistant variant of IL-18 synergize to engineer T cells for efficacious intratumoral adoptive immunotherapy.
Irene Olivera, Elixabet Bolaños, Jose Gonzalez-Gomariz, Sandra Hervas-Stubbs, Karina V Mariño, Assunta Cirella

Cell Rep Med· March 2023

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Intratumoral Gene Transfer of mRNAs Encoding IL12 in Combination with Decoy-Resistant IL18 Improves Local and Systemic Antitumor Immunity.
Assunta Cirella, Elixabet Bolaños, Claudia Augusta Di Trani, Carlos E de Andrea, Sandra Sánchez-Gregorio

Cancer Immunol Res· February 2023

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Depletion of Conventional Type-1 Dendritic Cells in Established Tumors Suppresses Immunotherapy Efficacy.
Alvaro Teijeira, Saray Garasa, Carlos Luri-Rey, Carlos de Andrea, Maria Gato, Assunta Cirella

Cancer Res· December 2022

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Intracavitary adoptive transfer of IL-12 mRNA-engineered tumor-specific CD8 T cells eradicates peritoneal metastases in mouse models.
Claudia Augusta Di Trani, Assunta Cirella, Leire Arrizabalaga, Ángela Bella, Myriam Fernandez-Sendin

Oncoimmunology· December 2022

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Novel strategies exploiting interleukin-12 in cancer immunotherapy.
Assunta Cirella, Carlos Luri-Rey, Claudia Augusta Di Trani, Alvaro Teijeira, Irene Olivera

Pharmacol Ther· November 2022

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A Therapeutically Actionable Protumoral Axis of Cytokines Involving IL-8, TNFα, and IL-1β.
Irene Olivera, Rebeca Sanz-Pamplona, Elixabet Bolaños, Inmaculada Rodriguez, Iñaki Etxeberria, Assunta Cirella

Cancer Discov· September 2022

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Overcoming the limitations of cytokines to improve cancer therapy.
Claudia Augusta Di Trani, Assunta Cirella, Leire Arrizabalaga, Myriam Fernandez-Sendin, Angela Bella

Int Rev Cell Mol Biol· July 2022

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Synergistic antitumor response with recombinant modified virus Ankara armed with CD40L and CD137L against peritoneal carcinomatosis.
Ángela Bella, Leire Arrizabalaga, Claudia Augusta Di Trani, Assunta Cirella, Myriam Fernandez-Sendin

Oncoimmunology· July 2022

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Soluble CD137 as a dynamic biomarker to monitor agonist CD137 immunotherapies.
Javier Glez-Vaz, Arantza Azpilikueta, Irene Olivera, Assunta Cirella, Alvaro Teijeira

J Immunother Cancer· March 2022

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Advances in mRNA-based drug discovery in cancer immunotherapy.
Claudia Augusta Di Trani, Myriam Fernandez-Sendin, Assunta Cirella, Aina Segués, Irene Olivera

Expert Opin Drug Discov· January 2022

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Differential Interleukin-8 thresholds for chemotaxis and netosis in human neutrophils.
Alvaro Teijeira, Saray Garasa, Maria Del Carmen Ochoa, Assunta Cirella, Irene Olivera

Eur J Immunol· September 2021

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Antitumor efficacy and reduced toxicity using an anti-CD137 Probody therapeutic.
Iñaki Etxeberria, Elixabet Bolaños, Alvaro Teijeira, Saray Garasa, Alba Yanguas, Assunta Cirella

Proc Natl Acad Sci U S A· June 2021

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IL8, Neutrophils, and NETs in a Collusion against Cancer Immunity and Immunotherapy.
Alvaro Teijeira, Saray Garasa, Maria C Ochoa, Maria Villalba, Irene Olivera, Assunta Cirella

Clin Cancer Res· May 2021

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Mouse Models of Peritoneal Carcinomatosis to Develop Clinical Applications.
Ángela Bella, Claudia Augusta Di Trani, Myriam Fernández-Sendin, Leire Arrizabalaga, Assunta Cirella

Cancers (Basel)· February 2021

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Type 2 immunity is maintained during cancer-associated adipose tissue wasting.
Patrick J Lenehan, Assunta Cirella, Amiko M Uchida, Stephanie J Crowley, Tatyana Sharova

Immunother Adv· January 2021

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Interleukin-12 Message in a Bottle.
Assunta Cirella, Pedro Berraondo, Claudia Augusta Di Trani, Ignacio Melero

Clin Cancer Res· December 2020

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An exercise-based educational and motivational intervention after surgery can improve behaviors, physical fitness and quality of life in bariatric patients.
Francesca Gallé, Gianpaolo Marte, Assunta Cirella, Mirella Di Dio, Alessandra Miele

PLoS One· December 2020

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CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune Cytotoxicity.
Álvaro Teijeira, Saray Garasa, María Gato, Carlos Alfaro, Itziar Migueliz, Assunta Cirella

Immunity· May 2020

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