Publications by authors named "Athanasios Metaxas"

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Serotonin-2B receptor (5-HTR) expression and binding in the brain of APP/PS1 transgenic mice and in Alzheimer's disease brain tissue.
Marco Anzalone, Sarmad A Karam, Sanne R R Briting, Sussanne Petersen, Majken B Thomsen, Athanasios Metaxas

Neurosci Lett· January 2025

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A systematic review and meta-analysis of tau phosphorylation in mouse models of familial Alzheimer's disease.
Malamati Kourti, Athanasios Metaxas

Neurobiol Dis· March 2024

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Natural antioxidants that act against Alzheimer's disease through modulation of the NRF2 pathway: a focus on their molecular mechanisms of action.
Grammatiki Alexandra Sidiropoulou, Athanasios Metaxas, Malamati Kourti

Front Endocrinol (Lausanne)· July 2023

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Editorial: Mechanisms, markers and therapeutics of synaptic pathology in Alzheimer's disease.
Athanasios Metaxas, Bente Finsen

Front Neurosci· October 2022

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Efficacy of Chronic Paroxetine Treatment in Mitigating Amyloid Pathology and Microgliosis in APPSWE/PS1ΔE9 Transgenic Mice.
Mithula Sivasaravanaparan, Louise Ørum Olesen, Maurizio Severino, Christian Ulrich von Linstow, Kate Lykke Lambertsen, Athanasios Metaxas

J Alzheimers Dis· May 2022

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Mild Microglial Responses in the Cortex and Perivascular Macrophage Infiltration in Subcortical White Matter in Dogs with Age-Related Dementia Modelling Prodromal Alzheimer's Disease.
Barbara Blicher Thomsen, Cecilie Madsen, Katrine Tækker Krohn, Camilla Thygesen, Trine Schütt, Athanasios Metaxas

J Alzheimers Dis· September 2021

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Tumor Necrosis Factor (TNF) Is Required for Spatial Learning and Memory in Male Mice under Physiological, but Not Immune-Challenged Conditions.
Leda Mygind, Marianne Skov-Skov Bergh, Vivien Tejsi, Ramanan Vaitheeswaran, Kate L Lambertsen, Athanasios Metaxas

Cells· March 2021

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Increased Inflammation and Unchanged Density of Synaptic Vesicle Glycoprotein 2A (SV2A) in the Postmortem Frontal Cortex of Alzheimer's Disease Patients.
Athanasios Metaxas, Camilla Thygesen, Sanne R R Briting, Anne M Landau, Sultan Darvesh

Front Cell Neurosci· December 2019

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Protective effect of ibuprofen in a rat model of chronic oxaliplatin-induced peripheral neuropathy.
Thomas Krøigård, Athanasios Metaxas, Martin Wirenfeldt, Bente Finsen

Exp Brain Res· October 2019

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Ageing and amyloidosis underlie the molecular and pathological alterations of tau in a mouse model of familial Alzheimer's disease.
Athanasios Metaxas, Camilla Thygesen, Stefan J Kempf, Marco Anzalone, Ramanan Vaitheeswaran

Sci Rep· October 2019

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Age-Dependent Changes in the Sarkosyl-Insoluble Proteome of APPSWE/PS1ΔE9 Transgenic Mice Implicate Dysfunctional Mitochondria in the Pathogenesis of Alzheimer's Disease.
Camilla Thygesen, Athanasios Metaxas, Martin R Larsen, Bente Finsen

J Alzheimers Dis· July 2019

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Neuroinflammation and amyloid-beta 40 are associated with reduced serotonin transporter (SERT) activity in a transgenic model of familial Alzheimer's disease.
Athanasios Metaxas, Marco Anzalone, Ramanan Vaitheeswaran, Sussanne Petersen, Anne M Landau

Alzheimers Res Ther· May 2019

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Binding characterization of N-(2-chloro-5-thiomethylphenyl)-N'-(3-[ H] methoxy phenyl)-N'-methylguanidine ([ H]GMOM), a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist.
Athanasios Metaxas, Bart N M van Berckel, Pieter J Klein, Joost Verbeek, Emily C Nash

Pharmacol Res Perspect· February 2019

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First in human evaluation of [F]PK-209, a PET ligand for the ion channel binding site of NMDA receptors.
Jasper van der Aart, Sandeep S V Golla, Marieke van der Pluijm, Lothar A Schwarte, Robert C Schuit, Athanasios Metaxas

EJNMMI Res· July 2018

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Established amyloid-β pathology is unaffected by chronic treatment with the selective serotonin reuptake inhibitor paroxetine.
Maurizio Severino, Mithula Sivasaravanaparan, Louise Ø Olesen, Christian U von Linstow, Athanasios Metaxas

Alzheimers Dement (N Y)· May 2018

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Reduced Serotonin Transporter Levels and Inflammation in the Midbrain Raphe of 12 Month Old APPswe/PSEN1dE9 Mice.
Athanasios Metaxas, Ramanan Vaitheeswaran, Katrine T Jensen, Camilla Thygesen, Laura Ilkjaer

Curr Alzheimer Res· March 2018

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Serotonin augmentation therapy by escitalopram has minimal effects on amyloid-β levels in early-stage Alzheimer's-like disease in mice.
Christian Ulrich von Linstow, Jonas Waider, Manuela Grebing, Athanasios Metaxas, Klaus Peter Lesch

Alzheimers Res Ther· September 2017

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TNFα affects CREB-mediated neuroprotective signaling pathways of synaptic plasticity in neurons as revealed by proteomics and phospho-proteomics.
Pia Jensen, Christa L Myhre, Pernille S Lassen, Athanasios Metaxas, Asif M Khan

Oncotarget· September 2017

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Synthesis, radiolabeling and preclinical evaluation of a [C]GMOM derivative as PET radiotracer for the ion channel of the N-methyl-D-aspartate receptor.
Pieter J Klein, Robert C Schuit, Athanasios Metaxas, Johannes A M Christiaans, Esther Kooijman

Nucl Med Biol· August 2017

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Characterization of [H] oxymorphone binding sites in mouse brain: Quantitative autoradiography in opioid receptor knockout mice.
Ji Hoon Yoo, Anna Borsodi, Géza Tóth, Sándor Benyhe, Robert Gaspar, Athanasios Metaxas

Neurosci Lett· March 2017

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Bis-pyridylethenyl benzene as novel backbone for amyloid-β binding compounds.
Rob J A Nabuurs, Varsha V Kapoerchan, Athanasios Metaxas, Sarah Hafith, Maaike de Backer

Bioorg Med Chem· December 2016

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Neurofibrillary tangles in Alzheimer's disease: elucidation of the molecular mechanism by immunohistochemistry and tau protein phospho-proteomics.
Athanasios Metaxas, Stefan J Kempf

Neural Regen Res· October 2016

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Synthesis, radiolabeling and evaluation of novel amine guanidine derivatives as potential positron emission tomography tracers for the ion channel of the N-methyl-d-aspartate receptor.
Pieter J Klein, Marion Chomet, Athanasios Metaxas, Johannes A M Christiaans, Esther Kooijman

Eur J Med Chem· August 2016

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Quantification of the novel N-methyl-d-aspartate receptor ligand [11C]GMOM in man.
Thalia F van der Doef, Sandeep S V Golla, Pieter J Klein, Gisela M Oropeza-Seguias, Robert C Schuit, Athanasios Metaxas

J Cereb Blood Flow Metab· June 2016

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An integrated proteomics approach shows synaptic plasticity changes in an APP/PS1 Alzheimer's mouse model.
Stefan J Kempf, Athanasios Metaxas, María Ibáñez-Vea, Sultan Darvesh, Bente Finsen

Oncotarget· June 2016

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