Publications by authors named "Atsuko Higashida"

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Association of bile acid composition with synthetic pathways and efficacy of bezafibrate in cholestatic liver disease.
Manami Iida, Atsuko Higashida, Shuichi Ohtomo, Akihito Takeuchi, Ryo Miura

Clin Mol Hepatol· October 2025

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Validation of a New Methodology to Create Oral Drugs beyond the Rule of 5 for Intracellular Tough Targets.
Atsushi Ohta, Mikimasa Tanada, Shojiro Shinohara, Yuya Morita, Kazuhiko Nakano, Atsuko Higashida

J Am Chem Soc· November 2023

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Selective TRK Inhibitor CH7057288 against TRK Fusion-Driven Cancer.
Hiroshi Tanaka, Hitoshi Sase, Toshiyuki Tsukaguchi, Masami Hasegawa, Hiromi Tanimura, Atsuko Higashida

Mol Cancer Ther· December 2018

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Hepatocellular carcinoma in a mouse model fed a choline-deficient, L-amino acid-defined, high-fat diet.
Ayae Ikawa-Yoshida, Saori Matsuo, Atsuhiko Kato, Yusuke Ohmori, Atsuko Higashida

Int J Exp Pathol· August 2017

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Prediction of drug-drug interactions based on time-dependent inhibition from high throughput screening of cytochrome P450 3A4 inhibition.
Nobuo Sekiguchi, Atsuko Higashida, Motohiro Kato, Yoshiaki Nabuchi, Tetsuya Mitsui

Drug Metab Pharmacokinet· April 2010

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Discovery of novel motilin antagonists: Conversion of tetrapeptide leads to orally available peptidomimetics.
Naoki Taka, Hiroharu Matsuoka, Tsutomu Sato, Hitoshi Yoshino, Ikuhiro Imaoka, Atsuko Higashida

Bioorg Med Chem Lett· July 2009

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Nonlinear intestinal pharmacokinetics of mitemcinal, the first acid-resistant non-peptide motilin receptor agonist, in rats.
Ryoichi Saitoh, Takashi Miyayama, Tetsuya Mitsui, Yuko Akiba, Atsuko Higashida

Xenobiotica· December 2007

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Oral absorption of poorly water-soluble drugs: computer simulation of fraction absorbed in humans from a miniscale dissolution test.
Ryusuke Takano, Kiyohiko Sugano, Atsuko Higashida, Yoshiki Hayashi, Minoru Machida

Pharm Res· June 2006

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Prediction of oral drug absorption in humans by theoretical passive absorption model.
Kouki Obata, Kiyohiko Sugano, Ryoichi Saitoh, Atsuko Higashida, Yoshiaki Nabuchi

Int J Pharm· April 2005

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Correction of permeability with pore radius of tight junctions in Caco-2 monolayers improves the prediction of the dose fraction of hydrophilic drugs absorbed by humans.
Ryoichi Saitoh, Kiyohiko Sugano, Noriyuki Takata, Tatsuhiko Tachibana, Atsuko Higashida

Pharm Res· May 2004

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