Publications by authors named "Audrey Nedelec"

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Delineating Mpl-dependent and -independent phenotypes of Jak2 V617F-positive MPNs in vivo.
Nicolas Papadopoulos, Audrey Nédélec, Yacine Rahmani, Hosuk Ryou, Jean-Philippe Defour

Blood· July 2025

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Modulation of human thrombopoietin receptor conformations uncouples JAK2 V617F-driven activation from cytokine-induced stimulation.
Nicolas Papadopoulos, Ajda Pristavec, Audrey Nédélec, Gabriel Levy, Judith Staerk

Blood· November 2023

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Oncogenic CALR mutant C-terminus mediates dual binding to the thrombopoietin receptor triggering complex dimerization and activation.
Nicolas Papadopoulos, Audrey Nédélec, Allison Derenne, Teodor Asvadur Şulea, Christian Pecquet

Nat Commun· April 2023

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Secreted mutant calreticulins as rogue cytokines in myeloproliferative neoplasms.
Christian Pecquet, Nicolas Papadopoulos, Thomas Balligand, Ilyas Chachoua, Amandine Tisserand

Blood· February 2023

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Penttinen syndrome-associated PDGFRB Val665Ala variant causes aberrant constitutive STAT1 signalling.
Audrey Nédélec, Emilie M Guérit, Guillaume Dachy, Sandrine Lenglez, Lok San Wong

J Cell Mol Med· July 2022

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Hematoxylin binds to mutant calreticulin and disrupts its abnormal interaction with thrombopoietin receptor.
Ruochen Jia, Thomas Balligand, Vasyl Atamanyuk, Harini Nivarthi, Erica Xu, Audrey Nedelec

Blood· April 2021

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Calreticulin del52 and ins5 knock-in mice recapitulate different myeloproliferative phenotypes observed in patients with MPN.
Camélia Benlabiod, Maira da Costa Cacemiro, Audrey Nédélec, Valérie Edmond, Delphine Muller

Nat Commun· September 2020

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Functional effects of PTPN11 (SHP2) mutations causing LEOPARD syndrome on epidermal growth factor-induced phosphoinositide 3-kinase/AKT/glycogen synthase kinase 3beta signaling.
Thomas Edouard, Jean-Philippe Combier, Audrey Nédélec, Sophie Bel-Vialar, Mélanie Métrich

Mol Cell Biol· May 2010

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