Publications by authors named "August Huang"

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Developing Topics.
Michael B Miller, Bowen Jin, Katherine Brown, Denis Smirnov, August Yue Huang

Alzheimers Dement· December 2025

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Combined somatic mutation and transcriptome analysis reveals region-specific differences in clonal architecture in human cortex.
Vinayak V Viswanadham, Sonia N Kim, Emre Caglayan, Ryan N Doan, Yanmei Dou, August Yue Huang

Cell Rep· November 2025

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Increased nucleotide metabolism alleviates Alzheimer's disease pathology.
Yizhou Yu, Michael B Miller, August Yue Huang, Bryan Wei Zhi Tan, Ivana Celardo

Cell Death Dis· October 2025

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Diverse somatic genomic alterations in single neurons in chronic traumatic encephalopathy.
Guanlan Dong, Chanthia C Ma, Shulin Mao, Katherine Sun-Mi Brown, Samuel M Naik, August Yue Huang

Science· October 2025

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Genetic Polymorphisms in Nuclear Receptors Drive Variations in Responses to Environmental Exposures.
Shaoqi Zuo, Kun Zhang, Jiayin Dai, Karl Fent, August Yue Huang

Environ Sci Technol· September 2025

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Cell-type-informed genotyping of mosaic focal epilepsies reveals cell-autonomous and non-cell-autonomous disease-associated transcriptional programs.
Sara Bizzotto, Maya Talukdar, Edward A Stronge, Rosita B Ramirez, Yingxi Yang, August Yue Huang

Proc Natl Acad Sci U S A· July 2025

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Clonal Hematopoiesis Mutations Increase Risk of Alzheimer's Disease with ε3/ε3 Genotype.
Jaejoon Choi, Kyung Sun Park, Yann Le Guen, Jong-Ho Park, Zinan Zhou, August Yue Huang

bioRxiv· May 2025

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Neurons accumulate disease-specific somatic genomic changes across tau pathologic states in Alzheimer's disease.
Bowen Jin, Katherine S-M Brown, Denis S Smirnov, Samuel M Naik, Samantha L Kirkham, August Yue Huang

bioRxiv· May 2025

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Cell-type-specific patterns and consequences of somatic mutation in development and aging brain.
Andrea J Kriz, Shulin Mao, Diane D Shao, Daniel A Snellings, Rebecca E Andersen, August Yue Huang

bioRxiv· May 2025

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Diverse somatic genomic alterations in single neurons in chronic traumatic encephalopathy.
Guanlan Dong, Chanthia C Ma, Shulin Mao, Samuel M Naik, Katherine Sun-Mi Brown, August Yue Huang

bioRxiv· March 2025

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Recurrent patterns of widespread neuronal genomic damage shared by major neurodegenerative disorders.
Zinan Zhou, Lovelace J Luquette, Guanlan Dong, Junho Kim, Jayoung Ku, August Yue Huang

bioRxiv· March 2025

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Analysis of DNA from brain tissue on stereo-EEG electrodes reveals mosaic epilepsy-related variants.
Alissa M D'Gama, H Westley Phillips, Yilan Wang, Michelle Y Chiu, Yasmine Chahine, August Yue Huang

Brain Commun· March 2025

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Somatic Genomic and Transcriptomic Changes in Single Ischemic Human Heart Cardiomyocytes.
Nazia Hilal, Zheming An, Maksymilian Prondzynski, Erica Matsui, Debesh Sahu, August Yue Huang

Res Sq· January 2025

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Neuropathologically directed profiling of PRNP somatic and germline variants in sporadic human prion disease.
Gannon A McDonough, Yuchen Cheng, Katherine S Morillo, Ryan N Doan, Zinan Zhou, August Yue Huang

Acta Neuropathol· July 2024

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Analysis of DNA from brain tissue on stereo-EEG electrodes reveals mosaic epilepsy-related variants.
Alissa M D'Gama, H Westley Phillips, Yilan Wang, Michelle Y Chiu, Yasmine Chahine, August Yue Huang

medRxiv· July 2024

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Neuropathologically-directed profiling of somatic and germline variants in sporadic human prion disease.
Gannon A McDonough, Yuchen Cheng, Katherine Morillo, Ryan N Doan, Connor J Kenny, August Yue Huang

bioRxiv· June 2024

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Single-nucleus multi-omic profiling of polyploid heart nuclei identifies fusion-derived cardiomyocytes in the human heart.
Sangita Choudhury, Indu Sivankutty, Youngsook Jung, August Huang, Sarah Araten

Res Sq· May 2024

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Somatic Mosaicism in Variant Correlates With Stereoelectroencephalography-Derived Electrophysiology.
H Westley Phillips, Alissa M D'Gama, Yilan Wang, Yasmine Chahine, Michelle Chiu, August Y Huang

Neurol Genet· February 2024

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Somatic cancer driver mutations are enriched and associated with inflammatory states in Alzheimer's disease microglia.
August Yue Huang, Zinan Zhou, Maya Talukdar, Michael B Miller, Brian Chhouk

bioRxiv· January 2024

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Somatic Mosaicism in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Reveals Widespread Degeneration from Focal Mutations.
Zinan Zhou, Junho Kim, August Yue Huang, Matthew Nolan, Junseok Park

bioRxiv· December 2023

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Cell lineage analysis with somatic mutations reveals late divergence of neuronal cell types and cortical areas in human cerebral cortex.
Sonia Nan Kim, Vinayak V Viswanadham, Ryan N Doan, Yanmei Dou, Sara Bizzotto, August Yue Huang

bioRxiv· November 2023

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Contribution of Somatic Ras/Raf/Mitogen-Activated Protein Kinase Variants in the Hippocampus in Drug-Resistant Mesial Temporal Lobe Epilepsy.
Sattar Khoshkhoo, Yilan Wang, Yasmine Chahine, E Zeynep Erson-Omay, Stephanie M Robert, August Yue Huang

JAMA Neurol· June 2023

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Prevalence and mechanisms of somatic deletions in single human neurons during normal aging and in DNA repair disorders.
Junho Kim, August Yue Huang, Shelby L Johnson, Jenny Lai, Laura Isacco

Nat Commun· October 2022

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Somatic mutations in single human cardiomyocytes reveal age-associated DNA damage and widespread oxidative genotoxicity.
Sangita Choudhury, August Yue Huang, Junho Kim, Zinan Zhou, Katherine Morillo

Nat Aging· August 2022

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Identification of Somatic Mutations From Bulk and Single-Cell Sequencing Data.
August Yue Huang, Eunjung Alice Lee

Front Aging· January 2022

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