Publications by authors named "Axel Facius"

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Population Pharmacokinetic and Exposure-Response Analysis of the Cognitive Effects of TAK-071 in Participants With Parkinson Disease and Cognitive Impairment.
Hongxia Jia, Axel Facius, Rachel Jennings, Yaming Hang, Jaya Padmanabhan

Clin Pharmacol Drug Dev· November 2025

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Mathematical model of the relationship between pH holding time and erosive esophagitis healing rates.
Colin W Howden, Carmelo Scarpignato, Eckhard Leifke, Darcy J Mulford, Gezim Lahu, Axel Facius

CPT Pharmacometrics Syst Pharmacol· January 2025

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Population pharmacokinetics, enzyme occupancy, and pharmacodynamic modeling of soticlestat in patients with developmental and epileptic encephalopathies.
Wei Yin, Axel Facius, Mahnaz Asgharnejad, Gëzim Lahu, Majid Vakilynejad

Clin Transl Sci· March 2024

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A translational pharmacokinetic/pharmacodynamic approach supports optimal vonoprazan dosing for erosive oesophagitis and Helicobacter pylori infection.
Carmelo Scarpignato, Colin W Howden, Eckhard Leifke, Darcy J Mulford, Gezim Lahu, Axel Facius

Aliment Pharmacol Ther· July 2023

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Population pharmacokinetics, enzyme occupancy, and 24S-hydroxycholesterol modeling of soticlestat, a novel cholesterol 24-hydroxylase inhibitor, in healthy adults.
Wei Yin, Axel Facius, Thomas Wagner, Max Tsai, Mahnaz Asgharnejad

Clin Transl Sci· July 2023

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A Population Pharmacokinetic Model of Vonoprazan: Evaluating the Effects of Race, Disease Status, and Other Covariates on Exposure.
Carmelo Scarpignato, Eckhard Leifke, Neila Smith, Darcy J Mulford, Gezim Lahu, Axel Facius

J Clin Pharmacol· June 2022

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What Can Be Learned From Crowdsourced Population Asparagus Urinary Odor Kinetics?
Axel Facius, Linda A Atkinson, Kelly Hanna, Mai Chi Coombes, Gezim Lahu

CPT Pharmacometrics Syst Pharmacol· June 2019

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Use of a 4-week up-titration regimen of roflumilast in patients with severe COPD.
Henrik Watz, Nitin Bagul, Klaus F Rabe, Stephen Rennard, Vijay Kt Alagappan, Axel Facius

Int J Chron Obstruct Pulmon Dis· September 2018

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Pharmacokinetic and Pharmacodynamic Modelling to Characterize the Tolerability of Alternative Up-Titration Regimens of Roflumilast in Patients with Chronic Obstructive Pulmonary Disease.
Axel Facius, Eleonora Marostica, Philip Gardiner, Henrik Watz, Gezim Lahu

Clin Pharmacokinet· August 2018

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Modeling and Simulation of Pivotal Clinical Trials Using Linked Models for Multiple Endpoints in Chronic Obstructive Pulmonary Disease With Roflumilast.
Axel Facius, Andreas Krause, Laurent Claret, Rene Bruno, Gezim Lahu

J Clin Pharmacol· August 2017

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Population pharmacokinetic meta-analysis to bridge ferumoxytol plasma pharmacokinetics across populations.
Nele Plock, Axel Facius, Gezim Lahu, Nolan Wood, Timothy Frigo

Clin Pharmacokinet· April 2015

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Utility of a population pharmacokinetic meta analysis during the approval process of teduglutide for the treatment of short bowel syndrome.
Stefan Roepcke, Ruediger Nave, Jane Cyran, Nele Plock, Gezim Lahu, Axel Facius

Int J Clin Pharmacol Ther· December 2014

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Application of population pharmacokinetic modeling to explore the impact of alternative roflumilast dosing regimens on tolerability.
Gezim Lahu, Axel Facius

Int J Clin Pharmacol Ther· November 2013

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An innovative phase I population pharmacokinetic approach to investigate the pharmacokinetics of an intranasal fentanyl spray in healthy subjects.
Nele Plock, Axel Facius, Lene Hartmann, Sybille Baumann, Rüdiger Nave

Int J Clin Pharmacol Ther· June 2013

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Population pharmacokinetic meta-analysis of intranasal fentanyl spray as a means to enrich pharmacokinetic information for patients with cancer breakthrough pain.
Nele Kaessner, Rüdiger Nave, Stefan Roepcke, Axel Facius, Gezim Lahu

Int J Clin Pharmacol Ther· September 2012

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Population pharmacokinetic modelling of roflumilast and roflumilast N-oxide by total phosphodiesterase-4 inhibitory activity and development of a population pharmacodynamic-adverse event model.
Gezim Lahu, Andreas Hünnemeyer, Edgar Diletti, Martin Elmlinger, Peter Ruth, Axel Facius

Clin Pharmacokinet· September 2010

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Prion-induced activation of cholesterogenic gene expression by Srebp2 in neuronal cells.
Christian Bach, Sabine Gilch, Romina Rost, Alex D Greenwood, Marion Horsch, Axel Facius

J Biol Chem· November 2009

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Bioinformatics challenges in proteomics.
Claudia C Englbrecht, Axel Facius

Comb Chem High Throughput Screen· December 2005

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Super paramagnetic clustering of protein sequences.
Igor V Tetko, Axel Facius, Andreas Ruepp, Hans-Werner Mewes

BMC Bioinformatics· April 2005

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Gene selection from microarray data for cancer classification--a machine learning approach.
Yu Wang, Igor V Tetko, Mark A Hall, Eibe Frank, Axel Facius

Comput Biol Chem· February 2005

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PRIME: a graphical interface for integrating genomic/proteomic databases.
Axel Facius, Claudia Englbrecht, Fabian Birzele, Andreas Groscurth, Schmidt Benjamin

Proteomics· January 2005

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Iterative data analysis is the key for exhaustive analysis of peptide mass fingerprints from proteins separated by two-dimensional electrophoresis.
Frank Schmidt, Monika Schmid, Peter R Jungblut, Jens Mattow, Axel Facius

J Am Soc Mass Spectrom· September 2003

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