Publications by authors named "Axel T Brunger"

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Synaptobrevin-2 disease variants reveal spatial constraints within the presynaptic active zone.
Natalie J Guzikowski, Elena D Bagatelas, Ok-Ho Shin, Yousuf A Khan, Luis Esquivies, Axel T Brunger

Proc Natl Acad Sci U S A· November 2025

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SNARE disassembly requires Sec18/NSF side loading.
Yousuf A Khan, K Ian White, Richard A Pfuetzner, Bharti Singal, Luis Esquivies, Axel T Brunger

Nat Struct Mol Biol· September 2025

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Structural remodeling of target-SNARE protein complexes by NSF enables synaptic transmission.
K Ian White, Yousuf A Khan, Kangqiang Qiu, Ashwin Balaji, Sergio Couoh-Cardel, Axel T Brunger

Nat Commun· September 2025

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Structural remodeling of target-SNARE protein complexes by NSF enables synaptic transmission.
K Ian White, Yousuf A Khan, Kangqiang Qiu, Ashwin Balaji, Sergio Couoh-Cardel, Axel T Brunger

bioRxiv· July 2025

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SNARE disassembly requires Sec18/NSF side-loading.
Yousuf A Khan, K Ian White, Richard A Pfuetzner, Bharti Singal, Luis Esquivies, Axel T Brunger

bioRxiv· June 2025

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Author Correction: Structure and topography of the synaptic V-ATPase-synaptophysin complex.
Chuchu Wang, Wenhong Jiang, Jeremy Leitz, Kailu Yang, Luis Esquivies, Axel T Brunger

Nature· June 2025

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Author Correction: Observing isolated synaptic vesicle association and fusion ex vivo.
Jeremy Leitz, Chuchu Wang, Luis Esquivies, John J Peters, Nisha Gopal, Axel T Brunger

Nat Protoc· June 2025

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Observing isolated synaptic vesicle association and fusion ex vivo.
Jeremy Leitz, Chuchu Wang, Luis Esquivies, John J Peters, Nisha Gopal, Axel T Brunger

Nat Protoc· November 2024

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Structure and Topography of AMPA Receptor Scaffolding Complexes Visualized by CryoET.
Richard G Held, Jiahao Liang, Luis Esquivies, Yousuf A Khan, Chuchu Wang, Axel T Brunger

bioRxiv· October 2024

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VAMP2 chaperones α-synuclein in synaptic vesicle co-condensates.
Chuchu Wang, Kai Zhang, Bin Cai, Jillian E Haller, Kathryn E Carnazza, Axel T Brunger

Nat Cell Biol· August 2024

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Structure and topography of the synaptic V-ATPase-synaptophysin complex.
Chuchu Wang, Wenhong Jiang, Jeremy Leitz, Kailu Yang, Luis Esquivies, Axel T Brunger

Nature· July 2024

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Nanoscale architecture of synaptic vesicles and scaffolding complexes revealed by cryo-electron tomography.
Richard G Held, Jiahao Liang, Axel T Brunger

Proc Natl Acad Sci U S A· July 2024

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Beyond the MUN domain, Munc13 controls priming and depriming of synaptic vesicles.
Jeremy Leitz, Chuchu Wang, Luis Esquivies, Richard A Pfuetzner, John Jacob Peters, Axel T Brunger

Cell Rep· May 2024

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A new method for isolation and purification of fusion-competent inhibitory synaptic vesicles.
Nisha Gopal, Jeremy Leitz, Chuchu Wang, Luis Esquivies, Richard A Pfuetzner, Axel T Brunger

Curr Res Physiol· February 2024

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Neutral lysophosphatidylcholine mediates α-synuclein-induced synaptic vesicle clustering.
Ying Lai, Chunyu Zhao, Zhiqi Tian, Chuchu Wang, Jiaqi Fan, Axel T Brunger

Proc Natl Acad Sci U S A· October 2023

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Sensory deficit screen identifies nsf mutation that differentially affects SNARE recycling and quality control.
Yan Gao, Yousuf A Khan, Weike Mo, K Ian White, Matthew Perkins, Axel T Brunger

Cell Rep· April 2023

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Structure-based design of a SARS-CoV-2 Omicron-specific inhibitor.
Kailu Yang, Chuchu Wang, Alex J B Kreutzberger, K Ian White, Richard A Pfuetzner, Axel T Brunger

Proc Natl Acad Sci U S A· March 2023

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The Core Complex of the Ca-Triggered Presynaptic Fusion Machinery.
Axel T Brunger, Jeremy Leitz

J Mol Biol· January 2023

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Analysis of tripartite Synaptotagmin-1-SNARE-complexin-1 complexes in solution.
Klaudia Jaczynska, Luis Esquivies, Richard A Pfuetzner, Baris Alten, Kyle D Brewer, Axel T Brunger

FEBS Open Bio· January 2023

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Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein.
Kailu Yang, Chuchu Wang, Alex J B Kreutzberger, Ravi Ojha, Suvi Kuivanen, Axel T Brunger

Proc Natl Acad Sci U S A· October 2022

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Discovery of a drug to treat airway mucus hypersecretion.
Burton F Dickey, Ying Lai, Manfred Frick, Axel T Brunger

Clin Transl Med· August 2022

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Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the pre-hairpin intermediate of the spike protein.
Kailu Yang, Chuchu Wang, Alex J B Kreutzberger, Ravi Ojha, Suvi Kuivanen, Axel T Brunger

bioRxiv· August 2022

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A feature-guided, focused 3D signal permutation method for subtomogram averaging.
John Jacob Peters, Jeremy Leitz, Qiang Guo, Florian Beck, Wolfgang Baumeister, Axel T Brunger

J Struct Biol· June 2022

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Screening of Hydrocarbon-Stapled Peptides for Inhibition of Calcium-Triggered Exocytosis.
Ying Lai, Michael J Tuvim, Jeremy Leitz, John Peters, Richard A Pfuetzner, Axel T Brunger

Front Pharmacol· June 2022

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Structural conservation among variants of the SARS-CoV-2 spike postfusion bundle.
Kailu Yang, Chuchu Wang, K Ian White, Richard A Pfuetzner, Luis Esquivies, Axel T Brunger

Proc Natl Acad Sci U S A· April 2022

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