Publications by authors named "Bailing Xu"

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E
Employing a Highly Potent Fluorescence Probe to Discover a Poly (Adenosine Diphosphate-ribose) Polymerases-1/2 Binder and the Complex Structures Analysis.
Xiaoyu Wang, Chengyan Wang, Jinruo Li, Jie Zhou, Bailing Xu

ChemMedChem· December 2025

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Discovery of Novel Isoindolin-1-one Derivatives as GABA Receptors Positive Allosteric Modulators with Antiepileptic Efficacy.
Meizhen Tian, Jun Wu, Leqi Fan, Jie Zhou, Xiaoyu Wang, Bailing Xu

J Med Chem· August 2025

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Engaging an engineered PARP-2 catalytic domain mutant to solve the complex structures harboring approved drugs for structure analyses.
Xiaoyu Wang, Jie Zhou, Bailing Xu

Bioorg Chem· June 2025

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Discovery of Isobenzofuran-1(3)-one Derivatives as Selective TREK-1 Inhibitors with In Vitro and In Vivo Neuroprotective Effects.
Kaiyue Liu, Yunyun Ji, Yiming Xie, Chengyan Wang, Jie Zhou, Bailing Xu

J Med Chem· March 2025

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Discovery of Novel Pyrimidine Derivatives as Human Pin1 Covalent Inhibitors.
Meizhen Tian, Xiaoyu Wang, Guodong Tang, Guonan Cui, Jie Zhou, Bailing Xu

ACS Med Chem Lett· January 2025

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Discovery of 4-(Arylethynyl)piperidine Derivatives as Potent Nonsaccharide -GlcNAcase Inhibitors for the Treatment of Alzheimer's Disease.
Zihan Cheng, Nianying Shang, Xiaoyu Wang, Yuying Kang, Jie Zhou, Bailing Xu

J Med Chem· August 2024

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Discovery of 2-Ethoxy-5-isobutyramido--1-substituted Benzamide Derivatives as Selective Kv2.1 Inhibitors with In Vivo Neuroprotective Effects.
Jie Zhou, Weiping Wang, Dong Liu, Shaofeng Xu, Xue Wang, Bailing Xu

J Med Chem· January 2024

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An in silico investigation of Kv2.1 potassium channel: Model building and inhibitors binding sites analysis.
Xiaoyu Wang, Xinyuan Zhang, Jie Zhou, Weiping Wang, Xiaoliang Wang, Bailing Xu

Mol Inform· December 2023

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Discovery of Quinazoline-2,4(1,3)-dione Derivatives Containing a Piperizinone Moiety as Potent PARP-1/2 Inhibitors─Design, Synthesis, Antitumor Activity, and X-ray Crystal Structure Analysis.
Jie Zhou, Tingting Du, Xiaoyu Wang, Haiping Yao, Jialing Deng, Bailing Xu

J Med Chem· October 2023

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Discovery of -Arylsulfonyl-Indole-2-Carboxamide Derivatives as Galectin-3 and Galectin-8 C-Terminal Domain Inhibitors.
Haoming Zhang, Xiaoyu Wang, Yanjun Wan, Liheng Liu, Jie Zhou, Bailing Xu

ACS Med Chem Lett· September 2023

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Discovery of 3, 6-disubstituted isobenzofuran-1(3H)-ones as novel inhibitors of monoamine oxidases.
Kaiyue Liu, Shiqi Zhou, Jie Zhou, Ruxue Bo, Xiaoyu Wang, Tong Xu, Bailing Xu

Bioorg Med Chem Lett· July 2022

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A Novel PARP Inhibitor YHP-836 For the Treatment of BRCA-Deficiency Cancers.
Tingting Du, Zhihui Zhang, Jie Zhou, Li Sheng, Haiping Yao, Bailing Xu

Front Pharmacol· July 2022

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Discovery of Novel Indole Derivatives as Fructose-1,6-bisphosphatase Inhibitors and X-ray Cocrystal Structures Analysis.
Xiaoyu Wang, Rui Zhao, Wenming Ji, Jie Zhou, Quan Liu, Bailing Xu

ACS Med Chem Lett· January 2022

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Discovery of Quinazoline-2,4(1,3)-dione Derivatives Containing 3-Substituted Piperizines as Potent PARP-1/2 Inhibitors─Design, Synthesis, Antitumor Activity, and X-ray Crystal Structure Analysis.
Jie Zhou, Ming Ji, Xiaoyu Wang, Hailong Zhao, Ran Cao, Bailing Xu

J Med Chem· November 2021

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Quantitative determination of Cpd118, A novel FBPase inhibitor, in dog plasma by HPLC-MS/MS.
Jinping Hu, Jie Zhou, Yanhong Sun, Huixin Tan, Fenghe Wang, Bailing Xu

Bioanalysis· June 2021

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Design, synthesis and biological evaluation of novel thiazole-based derivatives as human Pin1 inhibitors.
Lifei Du, Xiaoyu Wang, Guonan Cui, Bailing Xu

Bioorg Med Chem· January 2021

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Discovery of -Arylsulfonyl-Indole-2-Carboxamide Derivatives as Potent, Selective, and Orally Bioavailable Fructose-1,6-Bisphosphatase Inhibitors-Design, Synthesis, Glucose Lowering Effects, and X-ray Crystal Complex Analysis.
Jie Zhou, Jianbo Bie, Xiaoyu Wang, Quan Liu, Rongcui Li, Bailing Xu

J Med Chem· September 2020

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Design, synthesis and biological evaluation of indole-2-carboxylic acid derivatives as IDO1/TDO dual inhibitors.
Guonan Cui, Fangfang Lai, Xiaoyu Wang, Xiaoguang Chen, Bailing Xu

Eur J Med Chem· February 2020

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Synthesis and biological evaluation of pyrimidine derivatives as novel human Pin1 inhibitors.
Guonan Cui, Jing Jin, Hualong Chen, Ran Cao, Xiaoguang Chen, Bailing Xu

Bioorg Med Chem· May 2018

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Discovery of quinazoline-2,4(1H,3H)-dione derivatives as novel PARP-1/2 inhibitors: design, synthesis and their antitumor activity.
Jie Zhou, Ming Ji, Haiping Yao, Ran Cao, Hailong Zhao, Bailing Xu

Org Biomol Chem· May 2018

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Discovery of novel quinazoline-2,4(1H,3H)-dione derivatives as potent PARP-2 selective inhibitors.
Hailong Zhao, Ming Ji, Guonan Cui, Jie Zhou, Fangfang Lai, Bailing Xu

Bioorg Med Chem· August 2017

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Discovery of 2-substituted 1H-benzo[d]immidazole-4-carboxamide derivatives as novel poly(ADP-ribose)polymerase-1 inhibitors with in vivo anti-tumor activity.
Jie Zhou, Ming Ji, Zhixiang Zhu, Ran Cao, Xiaoguang Chen, Bailing Xu

Eur J Med Chem· May 2017

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Synthesis and Pin1 inhibitory activity of thiazole derivatives.
Hailong Zhao, Guonan Cui, Jing Jin, Xiaoguang Chen, Bailing Xu

Bioorg Med Chem· November 2016

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Poly (ADP-ribose) polymerases inhibitor, Zj6413, as a potential therapeutic agent against breast cancer.
Qin Zhou, Ming Ji, Jie Zhou, Jing Jin, Nina Xue, Bailing Xu

Biochem Pharmacol· May 2016

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[2,3-Dihydro-1H-pyrrolo[3,2-c]quinoline and 2,3,5,9b-tetrahydro-1H-pyrrolo[3,2-c]-quinoline derivatives:synthesis and their inhibitory activity against Kv2.1].
Dong Liu, Ting-ting Guo, Wei-ping Wang, Xiao-liang Wang, Bai-ling Xu

Yao Xue Xue Bao· May 2016

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