Publications by authors named "Baiwei Lin"

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HypoxyStat, a small-molecule form of hypoxia therapy that increases oxygen-hemoglobin affinity.
Skyler Y Blume, Ankur Garg, Yolanda Martí-Mateos, Ayush D Midha, Brandon T L Chew, Baiwei Lin

Cell· March 2025

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Dapagliflozin attenuates fat accumulation and insulin resistance in obese mice with polycystic ovary syndrome.
Baiwei Lin, Xiaodan Guo, Wenjing Lu, Rui Niu, Xiying Zeng

Eur J Pharmacol· August 2024

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Fat-free mass index is a feasible predictor of insulin resistance in women with polycystic ovary syndrome: Evidence from a cross-sectional study.
Jinru Guo, Baiwei Lin, Rui Niu, Wenjing Lu, Chunmei He, Mulin Zhang

Endocrine· May 2024

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Small-molecule inhibition of glycogen synthase 1 for the treatment of Pompe disease and other glycogen storage disorders.
Julie C Ullman, Kevin T Mellem, Yannan Xi, Vyas Ramanan, Hanne Merritt, Baiwei Lin

Sci Transl Med· January 2024

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Time-restricted feeding improves metabolic and endocrine profiles in mice with polycystic ovary syndrome.
Yan Han, Baiwei Lin, Wenjing Lu, Xu Wang, Wenshuai Tang

Front Endocrinol (Lausanne)· January 2023

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Uncialamycin-based antibody-drug conjugates: Unique enediyne ADCs exhibiting bystander killing effect.
K C Nicolaou, Stephan Rigol, Emmanuel N Pitsinos, Dipendu Das, Yong Lu, Baiwei Lin

Proc Natl Acad Sci U S A· June 2021

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Design, Synthesis, and Biological Evaluation of Tubulysin Analogues, Linker-Drugs, and Antibody-Drug Conjugates, Insights into Structure-Activity Relationships, and Tubulysin-Tubulin Binding Derived from X-ray Crystallographic Analysis.
K C Nicolaou, Saiyong Pan, Kiran K Pulukuri, Qiuji Ye, Stephan Rigol, Baiwei Lin

J Org Chem· February 2021

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Evaluation of PNU-159682 antibody drug conjugates (ADCs).
Dane Holte, Joseph P Lyssikatos, Amanda M Valdiosera, Zachary Swinney, Vikram Sisodiya, Baiwei Lin

Bioorg Med Chem Lett· December 2020

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Streamlined Symmetrical Total Synthesis of Disorazole B and Design, Synthesis, and Biological Investigation of Disorazole Analogues.
K C Nicolaou, Johannes Krieger, Ganesh M Murhade, Parthasarathi Subramanian, Balu D Dherange, Baiwei Lin

J Am Chem Soc· September 2020

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Synthesis and Biological Evaluation of Shishijimicin A-Type Linker-Drugs and Antibody-Drug Conjugates.
K C Nicolaou, Ruofan Li, Qifeng Chen, Zhaoyong Lu, Emmanuel N Pitsinos, Baiwei Lin

J Am Chem Soc· July 2020

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Design, Synthesis, and Biological Investigation of Epothilone B Analogues Featuring Lactone, Lactam, and Carbocyclic Macrocycles, Epoxide, Aziridine, and 1,1-Difluorocyclopropane and Other Fluorine Residues.
K C Nicolaou, Yogesh G Shelke, Balu D Dherange, Aaron Kempema, Baiwei Lin

J Org Chem· March 2020

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Novel markers to track oxidative polysorbate degradation in pharmaceutical formulations.
Sanket Dahotre, Anthony Tomlinson, Baiwei Lin, Sandeep Yadav

J Pharm Biomed Anal· August 2018

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Measuring experimental cyclohexane-water distribution coefficients for the SAMPL5 challenge.
Ariën S Rustenburg, Justin Dancer, Baiwei Lin, Jianwen A Feng, Daniel F Ortwine

J Comput Aided Mol Des· November 2016

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De Novo Guanine Biosynthesis but Not the Riboswitch-Regulated Purine Salvage Pathway Is Required for Staphylococcus aureus Infection In Vivo.
Eric M Kofoed, Donghong Yan, Anand K Katakam, Mike Reichelt, Baiwei Lin

J Bacteriol· July 2016

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A high throughput solubility assay for drug discovery using microscale shake-flask and rapid UHPLC-UV-CLND quantification.
Baiwei Lin, Joseph H Pease

J Pharm Biomed Anal· April 2016

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Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety.
Chudi O Ndubaku, James J Crawford, Joy Drobnick, Ignacio Aliagas, David Campbell, Baiwei Lin

ACS Med Chem Lett· December 2015

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Polysorbate 20 Degradation in Biopharmaceutical Formulations: Quantification of Free Fatty Acids, Characterization of Particulates, and Insights into the Degradation Mechanism.
Anthony Tomlinson, Barthélemy Demeule, Baiwei Lin, Sandeep Yadav

Mol Pharm· November 2015

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A novel method for high throughput lipophilicity determination by microscale shake flask and liquid chromatography tandem mass spectrometry.
Baiwei Lin, Joseph H Pease

Comb Chem High Throughput Screen· December 2013

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Cascade blue as a donor for resonance energy transfer studies of heme-containing proteins.
Ross M Taylor, Baiwei Lin, Thomas R Foubert, James B Burritt, Jan Sunner

Anal Biochem· March 2002

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