Publications by authors named "Barbara Denearing"

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Intestinal inflammation induced by heat-labile toxin-producing enterotoxigenic E: Coli infection and impact on immune responses in an experimental human challenge model.
Xueyan Zhang, Jessica Brubaker, Kawsar R Talaat, Chad K Porter, Brittany L Feijoo, Barbara DeNearing

PLoS Negl Trop Dis· October 2025

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Validation of a Human Challenge Model Using an LT-Expressing Enterotoxigenic Strain (LSN03-016011) and Characterization of Potential Amelioration of Disease by an Investigational Oral Vaccine Candidate (VLA1701).
Kawsar R Talaat, Chad K Porter, Subhra Chakraborty, Brittany L Feijoo, Jessica Brubaker, Barbara DeNearing

Microorganisms· April 2024

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Efficacy Evaluation of an Intradermally Delivered Enterotoxigenic CF Antigen I Fimbrial Tip Adhesin Vaccine Coadministered with Heat-Labile Enterotoxin with LT(R192G) against Experimental Challenge with Enterotoxigenic H10407 in Healthy Adult Volunteers.
Ramiro L Gutiérrez, Chad K Porter, Clayton Harro, Kawsar Talaat, Mark S Riddle, Barbara DeNearing

Microorganisms· January 2024

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Immune response characterization in a human challenge study with a Shigella flexneri 2a bioconjugate vaccine.
Kristen A Clarkson, Kawsar R Talaat, Cristina Alaimo, Patricia Martin, A Louis Bourgeois, Barbara DeNearing

EBioMedicine· April 2021

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Human challenge study with a Shigella bioconjugate vaccine: Analyses of clinical efficacy and correlate of protection.
Kawsar R Talaat, Cristina Alaimo, Patricia Martin, A Louis Bourgeois, Anita M Dreyer, Barbara DeNearing

EBioMedicine· April 2021

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Interrogation of a live-attenuated enterotoxigenic vaccine highlights features unique to wild-type infection.
Subhra Chakraborty, Arlo Randall, Tim J Vickers, Doug Molina, Clayton D Harro, Barbara DeNearing

NPJ Vaccines· August 2019

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Hyperimmune Bovine Colostral Anti-CS17 Antibodies Protect Against Enterotoxigenic Escherichia coli Diarrhea in a Randomized, Doubled-Blind, Placebo-Controlled Human Infection Model.
Stephen J Savarino, Robin McKenzie, David R Tribble, Chad K Porter, Aisling O'Dowd, Barbara DeNearing

J Infect Dis· July 2019

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Enterotoxigenic Escherichia coli-blood group A interactions intensify diarrheal severity.
Pardeep Kumar, F Matthew Kuhlmann, Subhra Chakraborty, A Louis Bourgeois, Jennifer Foulke-Abel, Barbara DeNearing

J Clin Invest· July 2019

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Live attenuated enterotoxigenic Escherichia coli (ETEC) vaccine with dmLT adjuvant protects human volunteers against virulent experimental ETEC challenge.
Clayton Harro, A Louis Bourgeois, David Sack, Richard Walker, Barbara DeNearing

Vaccine· March 2019

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Human Experimental Challenge With Enterotoxigenic Escherichia coli Elicits Immune Responses to Canonical and Novel Antigens Relevant to Vaccine Development.
Subhra Chakraborty, Arlo Randall, Tim J Vickers, Doug Molina, Clayton D Harro, Barbara DeNearing

J Infect Dis· September 2018

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Enterotoxigenic virulence gene regulation in human infections.
Alexander A Crofts, Simone M Giovanetti, Erica J Rubin, Frédéric M Poly, Ramiro L Gutiérrez, Barbara DeNearing

Proc Natl Acad Sci U S A· September 2018

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Enterotoxigenic Escherichia coli-blood group A interactions intensify diarrheal severity.
Pardeep Kumar, F Matthew Kuhlmann, Subhra Chakraborty, A Louis Bourgeois, Jennifer Foulke-Abel, Barbara DeNearing

J Clin Invest· August 2018

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Clinical endpoints in the controlled human challenge model for Shigella: A call for standardization and the development of a disease severity score.
Chad K Porter, Amanda Lynen, Mark S Riddle, Kawsar Talaat, David Sack, Barbara DeNearing

PLoS One· July 2018

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Rifaximin Fails to Prevent Campylobacteriosis in the Human Challenge Model: A Randomized, Double-Blind, Placebo-Controlled Trial.
Joanna E Rimmer, Clayton Harro, David A Sack, Kawsar R Talaat, Ramiro L Gutierrez, Barbara DeNearing

Clin Infect Dis· April 2018

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Campylobacter jejuni transcriptional and genetic adaptation during human infection.
Alexander A Crofts, Frédéric M Poly, Cheryl P Ewing, Janelle M Kuroiwa, Joanna E Rimmer, Barbara DeNearing

Nat Microbiol· April 2018

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Impact of lower challenge doses of enterotoxigenic Escherichia coli on clinical outcome, intestinal colonization and immune responses in adult volunteers.
Subhra Chakraborty, Clayton Harro, Barbara DeNearing, Jessica Brubaker, Sean Connor

PLoS Negl Trop Dis· April 2018

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Prophylactic Efficacy of Hyperimmune Bovine Colostral Antiadhesin Antibodies Against Enterotoxigenic Escherichia coli Diarrhea: A Randomized, Double-Blind, Placebo-Controlled, Phase 1 Trial.
Stephen J Savarino, Robin McKenzie, David R Tribble, Chad K Porter, Aisling O'Dowd, Barbara DeNearing

J Infect Dis· July 2017

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An Evidenced-Based Scale of Disease Severity following Human Challenge with Enteroxigenic Escherichia coli.
Chad K Porter, Mark S Riddle, Ashley N Alcala, David A Sack, Clayton Harro, Barbara DeNearing

PLoS One· August 2016

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Evaluation of the Safety, Tolerability, and Immunogenicity of an Oral, Inactivated Whole-Cell Shigella flexneri 2a Vaccine in Healthy Adult Subjects.
Subhra Chakraborty, Clayton Harro, Barbara DeNearing, Jay Bream, Nicole Bauers

Clin Vaccine Immunol· April 2016

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Characterization of Mucosal Immune Responses to Enterotoxigenic Escherichia coli Vaccine Antigens in a Human Challenge Model: Response Profiles after Primary Infection and Homologous Rechallenge with Strain H10407.
Subhra Chakraborty, Clayton Harro, Barbara DeNearing, Malathi Ram, Andrea Feller

Clin Vaccine Immunol· January 2016

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The oral, live attenuated enterotoxigenic Escherichia coli vaccine ACE527 reduces the incidence and severity of diarrhea in a human challenge model of diarrheal disease.
Michael J Darsley, Subhra Chakraborty, Barbara DeNearing, David A Sack, Andrea Feller

Clin Vaccine Immunol· December 2012

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A combination vaccine consisting of three live attenuated enterotoxigenic Escherichia coli strains expressing a range of colonization factors and heat-labile toxin subunit B is well tolerated and immunogenic in a placebo-controlled double-blind phase I trial in healthy adults.
Clayton Harro, David Sack, A Louis Bourgeois, R Walker, Barbara DeNearing

Clin Vaccine Immunol· December 2011

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Refinement of a human challenge model for evaluation of enterotoxigenic Escherichia coli vaccines.
Clayton Harro, Subhra Chakraborty, Andrea Feller, Barbara DeNearing, Alicia Cage

Clin Vaccine Immunol· October 2011

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Volunteer challenge with enterotoxigenic Escherichia coli that express intestinal colonization factor fimbriae CS17 and CS19.
Robin McKenzie, Chad K Porter, Joyce A Cantrell, Barbara Denearing, Aisling O'Dowd

J Infect Dis· July 2011

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