Publications by authors named "Barbara Slusher"

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Resilient pathways for drug discovery in challenging times.
Sean Ekins, Barbara S Slusher

Trends Pharmacol Sci· December 2025

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An orally bioavailable MrgprX1-positive allosteric modulator alleviates certain neuropathic pain-related behaviors in humanized mice.
Ankit Uniyal, Niyada Hin, Chi Zhang, Qian Xu, Qian Huang, Barbara S Slusher

Sci Transl Med· December 2025

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Targeting NAAG metabolism restores cognition and synaptic integrity in EcoHIV-infected mice.
Yuxin Zheng, Meixiang Huang, R Michael Maragakis, Peter Pietri, Yu Su, Barbara S Slusher

Neurotherapeutics· November 2025

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Region-specific proteomic analysis of aging rhesus macaques following chronic glutamate-carboxypeptidase-II (GCPII) inhibition elucidates potential treatment strategies for sporadic Alzheimer's disease.
Alexandra D Steigmeyer, Alexandria S Battison, Iris R Liebman, Christopher H van Dyck, Barbara S Slusher

bioRxiv· November 2025

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Inhibition of Glutamine Metabolism Attenuates Tumor Progression Through Remodeling of the Macrophage Immune Microenvironment.
Tianhe Li, Sepehr Akhtarkhavari, Sumeng Qi, Jiawei Fan, Tu-Yung Chang, Barbara S Slusher

Adv Biol (Weinh)· October 2025

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Inhibition of microglial glutaminase alleviates chronic stress-induced neurobehavioral and cognitive deficits.
Meixiang Huang, Yannan Li, Ajit G Thomas, Anjali Sharma, Wathsala Liyanage, Barbara S Slusher

Neurotherapeutics· October 2025

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Mass spectrometry-guided discovery of novel GCPII inhibitor scaffolds.
Robyn Wiseman, Ajit G Thomas, John Janiszewski, Nate Hoxie, Chae Bin Lee, Barbara S Slusher

Front Pharmacol· October 2025

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The potential of academic drug discovery: successes and challenges.
Matthew Stremlau, Barbara S Slusher

Expert Opin Drug Discov· September 2025

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Associations between cerebrospinal fluid N-acetyl-aspartyl-glutamate (NAAG) and cognitive function in people with HIV.
Atiksh Chandra, Jesse Alt, Raha M Dastgheyb, Rebecca T Veenhuis, Rana Rais, Barbara S Slusher

AIDS· September 2025

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Prodrugs 2-(Phosphonomethyl)pentanedioic Acid (2-PMPA) as Orally Available Glutamate Carboxypeptidase II Inhibitors.
Niyada Hin, Chae Bin Lee, Sadakatali Gori, Barbara S Slusher, Rana Rais

ACS Med Chem Lett· August 2025

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Development of a high-throughput dual-stream liquid chromatography-tandem mass spectrometry method to screen for inhibitors of glutamate carboxypeptidase II.
Nate Hoxie, Yixuan Qiu, Stephen C Kales, Rick Schneider, Xin Hu, Barbara S Slusher

Rapid Commun Mass Spectrom· May 2025

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JHU-2545 preferentially shields salivary glands and kidneys during PSMA-targeted imaging.
Michael T Nedelcovych, Ranjeet P Dash, Ying Wu, Eun Yong Choi, Rena S Lapidus, Barbara S Slusher

Eur J Nucl Med Mol Imaging· April 2025

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Discovery of Orally Available Prodrugs of Itaconate and Derivatives.
Chae Bin Lee, Ivan Šnajdr, Lukáš Tenora, Jesse Alt, Sadakatali Gori, Barbara S Slusher

J Med Chem· February 2025

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Inhibition of brain glutamate carboxypeptidase II (GCPII) to enhance cognitive function.
Robyn Wiseman, Kristin L Bigos, Amy F T Arnsten, Barbara S Slusher

Adv Pharmacol· February 2025

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Neutral sphingomyelinase 2: A promising drug target for CNS disease.
Meixiang Huang, Matthew Stremlau, Jason Zavras, Cristina Zivko, Ajit G Thomas, Barbara S Slusher

Adv Pharmacol· February 2025

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Correction: Nuclear GAPDH in cortical microglia mediates cellular stress-induced cognitive inflexibility.
Adriana Ramos, Koko Ishizuka, Arisa Hayashida, Ho Namkung, Lindsay N Hayes, Barbara S Slusher

Mol Psychiatry· January 2025

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Inhibition of Glutamine Metabolism Suppresses Tumor Progression through Remodeling of the Macrophage Immune Microenvironment.
Tianhe Li, Sepehr Akhtarkhavari, Tu-Yung Chang, Yao-An Shen, JinMing Yang, Barbara Slusher

bioRxiv· January 2025

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Pharmacokinetic Evaluation of Neutral Sphinghomyelinase2 (nSMase2) Inhibitor Prodrugs in Mice and Dogs.
Arina Ranjit, Chae Bin Lee, Lukáš Tenora, Vijaya Saradhi Mettu, Arindom Pal, Barbara S Slusher

Pharmaceutics· December 2024

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Dectin-1 as a therapeutic target for inflammatory bowel disease.
Yannan Li, Meixiang Huang, Santiago Cardinale, Yu Su, Diane E Peters, Barbara S Slusher

Adv Pharmacol· November 2024

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Development of Novel Tools for Dissection of Central Versus Peripheral Dopamine D2-Like Receptor Signaling in Dysglycemia.
Alessandro Bonifazi, Michael Ellenberger, Zachary J Farino, Despoina Aslanoglou, Rana Rais, Barbara S Slusher

Diabetes· September 2024

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Aged fibroblast-derived extracellular vesicles promote angiogenesis in melanoma.
Laura Hüser, Yash Chhabra, Olesia Gololobova, Vania Wang, Guanshu Liu, Barbara S Slusher

Cell Rep· September 2024

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Discovery of PSMA in the prostate of the common marmoset (Callithrix jacchus).
Diane E Peters, Michael Brownlee, Donna Layne-Colon, Barbara S Slusher

Prostate· August 2024

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Metabolic Reprogramming of Tumor-Associated Macrophages Using Glutamine Antagonist JHU083 Drives Tumor Immunity in Myeloid-Rich Prostate and Bladder Cancers.
Monali Praharaj, Fan Shen, Alex J Lee, Liang Zhao, Thomas R Nirschl, Barbara S Slusher

Cancer Immunol Res· July 2024

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Therapeutic resurgence of 6-diazo-5-oxo-l-norleucine (DON) through tissue-targeted prodrugs.
Kateřina Novotná, Lukáš Tenora, Barbara S Slusher, Rana Rais

Adv Pharmacol· July 2024

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GCPII Inhibition Promotes Remyelination after Peripheral Nerve Injury in Aged Mice.
Yu Su, Meixiang Huang, Ajit G Thomas, John Maragakis, Kaitlyn D J Huizar, Barbara S Slusher

Int J Mol Sci· June 2024

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