Publications by authors named "Bas Brouwers"

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Neural circuits expressing the serotonin 2C receptor regulate memory in mice and humans.
Hesong Liu, Yang He, Hailan Liu, Bas Brouwers, Na Yin

Sci Adv· June 2024

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Loss of hypothalamic Furin affects POMC to proACTH cleavage and feeding behavior in high-fat diet-fed mice.
Ilaria Coppola, Bas Brouwers, Leanne Walker, Ceyhun Alar, Sandra Meulemans

Mol Metab· December 2022

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Human loss-of-function variants in the serotonin 2C receptor associated with obesity and maladaptive behavior.
Yang He, Bas Brouwers, Hesong Liu, Hailan Liu, Katherine Lawler

Nat Med· December 2022

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Differential Effects of Deficiency on Insulin Receptor Processing and Glucose Control in Liver and Pancreatic β Cells of Mice.
Ilaria Coppola, Bas Brouwers, Sandra Meulemans, Bruno Ramos-Molina, John W M Creemers

Int J Mol Sci· June 2021

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Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation.
Bas Brouwers, Edson Mendes de Oliveira, Maria Marti-Solano, Fabiola B F Monteiro, Suli-Anne Laurin

Cell Rep· March 2021

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Loss of in β-Cells Induces an mTORC1-ATF4 Anabolic Pathway That Leads to β-Cell Dysfunction.
Bas Brouwers, Ilaria Coppola, Katlijn Vints, Bastian Dislich, Nathalie Jouvet

Diabetes· February 2021

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Human BDNF/TrkB variants impair hippocampal synaptogenesis and associate with neurobehavioural abnormalities.
Takuhiro Sonoyama, Lukas K J Stadler, Mingyan Zhu, Julia M Keogh, Elana Henning, Bas Brouwers

Sci Rep· June 2020

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Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity.
Luca A Lotta, Jacek Mokrosiński, Edson Mendes de Oliveira, Chen Li, Stephen J Sharp, Bas Brouwers

Cell· April 2019

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Quantitative mass spectrometry for human melanocortin peptides in vitro and in vivo suggests prominent roles for β-MSH and desacetyl α-MSH in energy homeostasis.
Peter Kirwan, Richard G Kay, Bas Brouwers, Vicente Herranz-Pérez, Magdalena Jura

Mol Metab· November 2018

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Transgenic Artifacts Caused by Passenger Human Growth Hormone.
Geoffroy de Faudeur, Bas Brouwers, Frans Schuit, John W M Creemers, Bruno Ramos-Molina

Trends Endocrinol Metab· October 2018

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Endosome to trans-Golgi network transport of Proprotein Convertase 7 is mediated by a cluster of basic amino acids and palmitoylated cysteines.
Jeroen Declercq, Bruno Ramos-Molina, Ragna Sannerud, Bas Brouwers, Vincent P E G Pruniau

Eur J Cell Biol· August 2017

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Metabolic and Behavioural Phenotypes in Nestin-Cre Mice Are Caused by Hypothalamic Expression of Human Growth Hormone.
Jeroen Declercq, Bas Brouwers, Vincent P E G Pruniau, Pieter Stijnen, Geoffroy de Faudeur

PLoS One· May 2016

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Liver-Specific Inactivation of the Proprotein Convertase FURIN Leads to Increased Hepatocellular Carcinoma Growth.
Jeroen Declercq, Bas Brouwers, Vincent P E G Pruniau, Pieter Stijnen, Krizia Tuand

Biomed Res Int· April 2016

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Human Growth Hormone in Transgenesis: A Growing Problem?
Bas Brouwers, John W M Creemers

Diabetes· November 2015

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Impaired islet function in commonly used transgenic mouse lines due to human growth hormone minigene expression.
Bas Brouwers, Geoffroy de Faudeur, Anna B Osipovich, Lotte Goyvaerts, Katleen Lemaire

Cell Metab· December 2014

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The AlfpCre mouse revisited: evidence for liver steatosis related to growth hormone deficiency.
Vincent P E G Pruniau, Els Louagie, Bas Brouwers, Jeroen Declercq, John W M Creemers

Hepatology· December 2013

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Phlorizin pretreatment reduces acute renal toxicity in a mouse model for diabetic nephropathy.
Bas Brouwers, Vincent P E G Pruniau, Elisa J G Cauwelier, Frans Schuit, Evelyne Lerut

J Biol Chem· September 2013

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