Publications by authors named "Basim Messiha"

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Nicardipine protects against gentamicin-induced nephrotoxicity: Potential involvement of IL-23R, NRF2, and Beclin-1 perturbation.
Marwa M N Ashour, Ahmed M Abd-Eldayem, Ehab A M El-Shoura, Basim A S Messiha, Souty M Z Sharkawi

Life Sci· December 2025

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Uro-Protective Role of Lacosamide Against Cyclophosphamide-Induced Cystitis via Notch1/NICD/NF-κB Pathway: Network Pharmacology, Molecular Docking, and Rat Model Validation.
Ahmed S Abdel-Samea, Mohammed R A Ali, Reham H Mohyeldin, Mina Ezzat Attya, Basim A S Messiha

Arch Pharm (Weinheim)· December 2025

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Saxagliptin mitigates doxorubicin-induced cardiotoxicity by modulating NLRP3/caspase-1/IL-1β and TLR-4/NF-κB pathways.
Maha M Abdel-Fattah, Yasmeen M Abozaid, Basim Anwar Shehata Messiha, Marwa M Khalaf

Toxicol Appl Pharmacol· December 2025

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Lacosamide as a chemoprotective agent beyond anticonvulsant activity: Pharmacological modulation of Notch-1/NF-κB axis to restore antioxidant defense, inhibit apoptosis, and preserve testosterone-androgen receptor signaling in cyclophosphamide-induced prostate injury.
Mohammed R A Ali, Basim A S Messiha, Ahmed S Abdel-Samea, Mina Ezzat Attya, Reham H Mohyeldin

Toxicol Appl Pharmacol· September 2025

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Oxyresveratrol and/or Dapagliflozin Attenuate Doxorubicin-Induced Nephrotoxicity via Modulation of PPAR-γ/Nrf-2/HO-1, NF-κB/TNF-α/Keap-1, and Bcl-2/Caspase-3/ATG-5 signaling pathways in rats.
Waleed S M El-Sawy, Marwa M Khalaf, Ali H El-Bahrawy, Basim A S Messiha, Ramadan A M Hemeida

Naunyn Schmiedebergs Arch Pharmacol· May 2025

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The protective effect of pregabalin and xanthenone on testicular ischemia/reperfusion injury in rats.
Maha M Abdel-Fattah, Ahmed Mamdouh Ahmed, Rabeh Khairy Saleh, Basim Anwar Shehata Messiha, Remon Roshdy Rofaeil

Fundam Clin Pharmacol· December 2024

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The impact of PPAR-γ/Nrf-2/HO-1, NF-κB/IL-6/ Keap-1, and Bcl-2/caspase-3/ATG-5 pathways in mitigation of DOX-induced cardiotoxicity in an animal model: The potential cardioprotective role of oxyresveratrol and/or dapagliflozin.
Waleed S M El-Sawy, Ali H El-Bahrawy, Basim A S Messiha, Ramadan A M Hemeida, Marwa M Khalaf

Food Chem Toxicol· September 2024

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Regulation of renal nitric oxide and eNOS/iNOS expression by tadalafil participates in the mitigation of amphotericin B-induced renal injury: Down-regulation of NF-κB/iNOS/caspase-3 signaling.
Doaa M Abdel-Rahman, Basim Anwar Shehata Messiha, Fares E M Ali, Amany A Azouz

Naunyn Schmiedebergs Arch Pharmacol· May 2024

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Cyclosporine-induced kidney damage was halted by sitagliptin and hesperidin via increasing Nrf2 and suppressing TNF-α, NF-κB, and Bax.
Ahmed M Abd-Eldayem, Sohayla Mahmoud Makram, Basim Anwar Shehata Messiha, Hanan H Abd-Elhafeez, Mustafa Ahmed Abdel-Reheim

Sci Rep· March 2024

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Lysosomal membrane stabilization by imipramine attenuates gentamicin-induced renal injury: Enhanced LAMP2 expression, down-regulation of cytoplasmic cathepsin D and tBid/cytochrome c/cleaved caspase-3 apoptotic signaling.
Dina A Hanna, Basim A S Messiha, Ali A Abo-Saif, Fares E M Ali, Amany A Azouz

Int Immunopharmacol· January 2024

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Balancing renal Ang-II/Ang-(1-7) by xanthenone; an ACE2 activator; contributes to the attenuation of Ang-II/p38 MAPK/NF-κB p65 and Bax/caspase-3 pathways in amphotericin B-induced nephrotoxicity in rats.
Amany A Azouz, Doaa M Abdel-Rahman, Basim Anwar Shehata Messiha

Toxicol Mech Methods· November 2023

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New insights into the cytoprotective mechanism of nano curcumin on neuronal damage in a vincristine-induced neuropathic pain rat model.
Wafaa Fouda, Amira Aboyoussef, Basim Messiha, Muhammed Salman, Ashraf Taye

Pak J Pharm Sci· January 2023

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Combination of Captopril with Gliclazide Decreases Vascular and Renal Complications and Improves Glycemic Control in Rats with Streptozotocin- Induced Diabetes Mellitus.
Sayed M M Mizar, Magy R Kozman, Ali A Abo-Saif, Basim A S Messiha

Endocr Metab Immune Disord Drug Targets· January 2022

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Granisetron attenuates liver injury and inflammation in a rat model of cecal ligation and puncture-induced sepsis.
Amira M Aboyoussef, Mostafa Kamal Mohammad, Ali Ahmed Abo-Saif, Basim A S Messiha

J Pharmacol Sci· December 2021

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Dabigatran mitigates cisplatin-mediated nephrotoxicity through down regulation of thrombin pathway.
Mohamed Gamal El-Din Ewees, Mohamed Sadek Abdel-Bakky, Asmaa Mostafa Ahmed Bayoumi, Ali Ahmed Abo-Saif, Waleed Mohammad Altowayan, Basim Anwar Shehata Messiha

J Adv Res· July 2021

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Resveratrol mitigates pancreatic TF activation and autophagy-mediated beta cell death via inhibition of CXCL16/ox-LDL pathway: A novel protective mechanism against type 1 diabetes mellitus in mice.
Mostafa A Darwish, Mohamed S Abdel-Bakky, Basim A S Messiha, Ali A Abo-Saif, Amira M Abo-Youssef

Eur J Pharmacol· June 2021

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Resveratrol inhibits macrophage infiltration of pancreatic islets in streptozotocin-induced type 1 diabetic mice via attenuation of the CXCL16/NF-κΒ p65 signaling pathway.
Mostafa A Darwish, Amira M Abo-Youssef, Basim A S Messiha, Ali A Abo-Saif, Mohamed S Abdel-Bakky

Life Sci· May 2021

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Enoxaparin prevents CXCL16/ADAM10-mediated cisplatin renal toxicity: Role of the coagulation system and the transcriptional factor NF-κB.
Amira M Aboyoussef, Asmaa Ramadan Abdel-Sattar, Mohamed Sadek Abdel-Bakky, Basim A S Messiha

Life Sci· April 2021

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Perindopril ameliorates experimental Alzheimer's disease progression: role of amyloid β degradation, central estrogen receptor and hyperlipidemic-lipid raft signaling.
Basim A S Messiha, Mohammed R A Ali, Mahmoud M Khattab, Amira M Abo-Youssef

Inflammopharmacology· October 2020

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The anti-Alzheimer effect of telmisartan in a hyperglycemic ovariectomized rat model; role of central angiotensin and estrogen receptors.
Amira M Abo-Youssef, Waleed A Khallaf, Mahmoud M Khattab, Basim A S Messiha

Food Chem Toxicol· August 2020

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The protective effect of inosine against rotenone-induced Parkinson's disease in mice; role of oxido-nitrosative stress, ERK phosphorylation, and A2AR expression.
Marwa E A El-Shamarka, Magy R Kozman, Basim A S Messiha

Naunyn Schmiedebergs Arch Pharmacol· June 2020

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Perindopril mitigates LPS-induced cardiopulmonary oxidative and inflammatory damage via inhibition of renin angiotensin system, inflammation and oxidative stress.
Ehab A M El-Shoura, Souty M Z Sharkawi, Basim A S Messiha, Adel G Bakr, Ramadan A M Hemeida

Immunopharmacol Immunotoxicol· December 2019

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Corrigendum: Interference With Coagulation Cascade as a Novel Approach to Counteract Cisplatin-Induced Acute Tubular Necrosis; an Experimental Study in Rats.
Mohamed G Ewees, Basim A S Messiha, Ali A Abo-Saif, Asmaa M A Bayoumi, Mohamed S Abdel-Bakky

Front Pharmacol· October 2019

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Gastro-Protective and Anti-Oxidant Potential of and on Pyloric Ligation/Indomethacin-Induced Ulceration in Rats.
Sameh S Zaghlool, Ali A Abo-Seif, Mohamed A Rabeh, Usama Ramadan Abdelmohsen, Basim A S Messiha

Antioxidants (Basel)· October 2019

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Interruption of platelets and thrombin function as a new approach against liver fibrosis induced experimentally in rats.
Nesreen Ishak Mahmoud, Basim A S Messiha, Ibrahim G Salehc, Ali A Abo-Saif, Mohamed S Abdel-Bakky

Life Sci· August 2019

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