Publications by authors named "Bassel Akache"

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Introduction to the Immune System.
Scott McComb, Aude Thiriot, Bassel Akache, Lakshmi Krishnan, Felicity C Stark

Methods Mol Biol· October 2025

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A Safe and Accessible Cell-Based Spike-ACE2 Binding Assay for Evaluating SARS-CoV-2 Neutralization Activity in Biological Samples Using Flow Cytometry.
Martin A Rossotti, Shannon Ryan, Greg Hussack, Jamshid Tanha, Bassel Akache

Methods Protoc· September 2025

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Modifying the glycosylation profile of SARS-CoV-2 spike-based subunit vaccines alters focusing of the humoral immune response in a mouse model.
Tyler M Renner, Matthew Stuible, Martin A Rossotti, Nazanin Rohani, Yuneivy Cepero-Donates, Bassel Akache

Commun Med (Lond)· April 2025

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Sulfated lactosyl archaeol (SLA) archaeosomes as a vaccine adjuvant.
Bassel Akache, Michael J McCluskie

Hum Vaccin Immunother· December 2024

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SARS-CoV-2 spike-based virus-like particles incorporate influenza H1/N1 antigens and induce dual immunity in mice.
Zalma V Sanchez-Martinez, Sergio P Alpuche-Lazcano, Matthew Stuible, Bassel Akache, Tyler M Renner

Vaccine· December 2024

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Reduced cross-protective potential of Omicron compared to ancestral SARS-CoV-2 spike vaccines against potentially zoonotic coronaviruses.
Tyler M Renner, Matthew Stuible, Brian Cass, Sylvie Perret, Julie Guimond, Bassel Akache

Npj Viruses· November 2024

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Intranasal administration of unadjuvanted SARS-CoV-2 spike antigen boosts antigen-specific immune responses induced by parenteral protein subunit vaccine prime in mice and hamsters.
Gerard Agbayani, Bassel Akache, Tyler M Renner, Anh Tran, Matthew Stuible

Eur J Immunol· June 2024

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Self-amplifying RNAs generated with the modified nucleotides 5-methylcytidine and 5-methyluridine mediate strong expression and immunogenicity .
Hiva Azizi, Tyler M Renner, Gerard Agbayani, Bryan Simard, Renu Dudani, Bassel Akache

NAR Mol Med· April 2024

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Production, purification and immunogenicity of Gag virus-like particles carrying SARS-CoV-2 components.
Anahita Bakhshizadeh Gashti, Gerard Agbayani, Sabahudin Hrapovic, Nasha Nassoury, Nathalie Coulombe, Bassel Akache

Vaccine· January 2024

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Effectiveness of VSV vectored SARS-CoV-2 spike when administered through intranasal, intramuscular or a combination of both.
Saina Beitari, Gerard Agbayani, Melissa Hewitt, Diana Duque, Jegarubee Bavananthasivam, Bassel Akache

Sci Rep· December 2023

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Preclinical evaluation of manufacturable SARS-CoV-2 spike virus-like particles produced in Chinese Hamster Ovary cells.
Sergio P Alpuche-Lazcano, Matthew Stuible, Bassel Akache, Anh Tran, John Kelly

Commun Med (Lond)· August 2023

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Tuning the immune response: sulfated archaeal glycolipid archaeosomes as an effective vaccine adjuvant for induction of humoral and cell-mediated immunity towards the SARS-CoV-2 Omicron variant of concern.
Tyler M Renner, Bassel Akache, Matthew Stuible, Nazanin Rohani, Yuneivy Cepero-Donates

Front Immunol· May 2023

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Sulfated Lactosyl Archaeol Archaeosome-Adjuvanted Vaccine Formulations Targeting Rabbit Hemorrhagic Disease Virus Are Immunogenic and Efficacious.
Bassel Akache, Andrew J Read, Renu Dudani, Blair A Harrison, Dean Williams

Vaccines (Basel)· May 2023

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Blood-Based Immune Protein Markers of Disease Progression in Murine Models of Acute and Chronic Inflammatory Bowel Disease.
Tyler Milston Renner, Gerard Agbayani, Renu Dudani, Michael J McCluskie, Bassel Akache

Biomedicines· January 2023

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Characterization of Systemic and Mucosal Humoral Immune Responses to an Adjuvanted Intranasal SARS-CoV-2 Protein Subunit Vaccine Candidate in Mice.
Mariam Maltseva, Yannick Galipeau, Tyler M Renner, Lise Deschatelets, Yves Durocher, Bassel Akache

Vaccines (Basel)· December 2022

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Immunogenicity of SARS-CoV-2 spike antigens derived from Beta & Delta variants of concern.
Bassel Akache, Tyler M Renner, Matthew Stuible, Nazanin Rohani, Yuneivy Cepero-Donates

NPJ Vaccines· October 2022

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Evaluation of Adjuvant Activity and Bio-Distribution of Archaeosomes Prepared Using Microfluidic Technology.
Yimei Jia, Gerard Agbayani, Vandana Chandan, Umar Iqbal, Renu Dudani, Bassel Akache

Pharmaceutics· October 2022

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Effect of Chiral Purity on Adjuvanticity of Archaeol-Based Glycolipids.
Sophie Régnier, Edmond Lam, Vinicio Vasquez, Camilo F Martinez-Farina, Felicity C Stark, Bassel Akache

J Med Chem· June 2022

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Intranasal immunization with a proteosome-adjuvanted SARS-CoV-2 spike protein-based vaccine is immunogenic and efficacious in mice and hamsters.
Felicity C Stark, Bassel Akache, Lise Deschatelets, Anh Tran, Matthew Stuible

Sci Rep· June 2022

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Adjuvants: Engineering Protective Immune Responses in Human and Veterinary Vaccines.
Bassel Akache, Felicity C Stark, Gerard Agbayani, Tyler M Renner, Michael J McCluskie

Methods Mol Biol· January 2022

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Generation of a Liposomal Vaccine Adjuvant Based on Sulfated S-Lactosylarchaeol (SLA) Glycolipids.
Bassel Akache, Yimei Jia, Vandana Chandan, Lise Deschatelets, Michael J McCluskie

Methods Mol Biol· January 2022

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Immunogenic and efficacious SARS-CoV-2 vaccine based on resistin-trimerized spike antigen SmT1 and SLA archaeosome adjuvant.
Bassel Akache, Tyler M Renner, Anh Tran, Lise Deschatelets, Renu Dudani

Sci Rep· November 2021

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Measurement of Antigen-Specific IgG Titers by Direct ELISA.
Bassel Akache, Felicity C Stark, Michael J McCluskie

Methods Mol Biol· March 2021

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The Synergistic Effects of Sulfated Lactosyl Archaeol Archaeosomes When Combined with Different Adjuvants in a Murine Model.
Yimei Jia, Bassel Akache, Gerard Agbayani, Vandana Chandan, Renu Dudani

Pharmaceutics· February 2021

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Sulfated Lactosyl Archaeol Archaeosomes Synergize with Poly(I:C) to Enhance the Immunogenicity and Efficacy of a Synthetic Long Peptide-Based Vaccine in a Melanoma Tumor Model.
Bassel Akache, Gerard Agbayani, Felicity C Stark, Yimei Jia, Renu Dudani

Pharmaceutics· February 2021

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