Publications by authors named "Beate Schwer"

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Fission yeast Tpt1 is composed of tandem RNA 2'-phosphotransferase and Yae1 domains, both of which are essential for viability.
Apurba Sarkar, Beate Schwer, Stewart Shuman

RNA· December 2025

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Genetic suppression of precocious transcription termination identifies mutations in essential subunits of the fission yeast cleavage and polyadenylation machinery.
Aleksei Innokentev, Ana M Sanchez, Lauren Bednor, Jill Babor, Beate Schwer

RNA· October 2025

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Structural basis for sensitivity and acquired resistance of fungal cap guanine-N7 methyltransferases to the antifungal antibiotic sinefungin.
Daniel J Nilson, Beate Schwer, Steven C Almo, Stewart Shuman, Agnidipta Ghosh

Nucleic Acids Res· July 2025

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Tandem inactivation of inositol pyrophosphatases Asp1, Siw14, and Aps1 illuminates functional redundancies in inositol pyrophosphate catabolism in fission yeast.
Beate Schwer, Isabel Prucker, Ana M Sanchez, Jill Babor, Henning J Jessen

mBio· May 2025

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Efn1 and Efn2 are extracellular 5'-nucleotidases induced during the fission yeast response to phosphate starvation.
Aleksei Innokentev, Ana M Sanchez, Mara Monetti, Beate Schwer, Stewart Shuman

mBio· January 2025

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Identification, characterization, and structure of a tRNA splicing enzyme RNA 5'-OH kinase from the pathogenic fungi Mucorales.
Shreya Ghosh, Gina Wimberly-Gard, Agata Jacewicz, Beate Schwer, Stewart Shuman

RNA· November 2024

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Activities and genetic interactions of fission yeast Aps1, a Nudix-type inositol pyrophosphatase and inorganic polyphosphatase.
Shreya Ghosh, Ana M Sanchez, Beate Schwer, Isabel Prucker, Nikolaus Jork

mBio· August 2024

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Suppression of inositol pyrophosphate toxicosis and hyper-repression of the fission yeast regulon by loss-of-function mutations in chromatin remodelers Snf22 and Sol1.
Beate Schwer, Aleksei Innokentev, Ana M Sanchez, Angad Garg, Stewart Shuman

mBio· July 2024

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Characterization of tRNA splicing enzymes RNA ligase and tRNA 2'-phosphotransferase from the pathogenic fungi Mucorales.
Shreya Ghosh, Swathi Dantuluri, Agata Jacewicz, Ana M Sanchez, Leonora Abdullahu, Beate Schwer

RNA· March 2024

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Factors governing the transcriptome changes and chronological lifespan of fission yeast during phosphate starvation.
Angad Garg, Ana M Sanchez, Beate Schwer, Stewart Shuman

J Biol Chem· March 2024

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Genetic suppressor screen identifies Tgp1 (glycerophosphocholine transporter), Kcs1 (IP kinase), and Plc1 (phospholipase C) as determinants of inositol pyrophosphate toxicosis in fission yeast.
Lauren Bednor, Ana M Sanchez, Angad Garg, Stewart Shuman, Beate Schwer

mBio· February 2024

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Fission yeast poly(A) polymerase active site mutation Y86D alleviates the Δ synthetic growth defect and up-regulates mRNAs targeted by MTREC and Mmi1.
Angad Garg, Beate Schwer, Stewart Shuman

RNA· November 2023

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Activities, substrate specificity, and genetic interactions of fission yeast Siw14, a cysteinyl-phosphatase-type inositol pyrophosphatase.
Ana M Sanchez, Beate Schwer, Nikolaus Jork, Henning J Jessen, Stewart Shuman

mBio· October 2023

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Duf89 abets lncRNA control of fission yeast phosphate homeostasis via its antagonism of precocious lncRNA transcription termination.
Ana M Sanchez, Angad Garg, Beate Schwer, Stewart Shuman

RNA· June 2023

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Cellular responses to long-term phosphate starvation of fission yeast: Maf1 determines fate choice between quiescence and death associated with aberrant tRNA biogenesis.
Angad Garg, Ana M Sanchez, Matthew Miele, Beate Schwer, Stewart Shuman

Nucleic Acids Res· April 2023

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Inorganic polyphosphate abets silencing of a sub-telomeric gene cluster in fission yeast.
Ana M Sanchez, Angad Garg, Beate Schwer, Stewart Shuman

MicroPubl Biol· February 2023

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Structures of Fission Yeast Inositol Pyrophosphate Kinase Asp1 in Ligand-Free, Substrate-Bound, and Product-Bound States.
Bradley Benjamin, Yehuda Goldgur, Nikolaus Jork, Henning J Jessen, Beate Schwer

mBio· December 2022

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Activities and Structure-Function Analysis of Fission Yeast Inositol Pyrophosphate (IPP) Kinase-Pyrophosphatase Asp1 and Its Impact on Regulation of Gene Expression.
Bradley Benjamin, Angad Garg, Nikolaus Jork, Henning J Jessen, Beate Schwer

mBio· June 2022

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Cleavage-Polyadenylation Factor Cft1 and SPX Domain Proteins Are Agents of Inositol Pyrophosphate Toxicosis in Fission Yeast.
Beate Schwer, Angad Garg, Ana M Sanchez, Mindy A Bernstein, Bradley Benjamin

mBio· February 2022

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Genetic screen for suppression of transcriptional interference reveals fission yeast 14-3-3 protein Rad24 as an antagonist of precocious Pol2 transcription termination.
Angad Garg, Stewart Shuman, Beate Schwer

Nucleic Acids Res· January 2022

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Genetic screen for suppression of transcriptional interference identifies a gain-of-function mutation in Pol2 termination factor Seb1.
Beate Schwer, Angad Garg, Agata Jacewicz, Stewart Shuman

Proc Natl Acad Sci U S A· August 2021

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Activity and substrate specificity of , , and Tpt1: essential tRNA splicing enzymes and potential antifungal targets.
Swathi Dantuluri, Beate Schwer, Leonora Abdullahu, Masad J Damha, Stewart Shuman

RNA· April 2021

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Transcriptional profiling of fission yeast RNA polymerase II CTD mutants.
Angad Garg, Ana M Sanchez, Beate Schwer, Stewart Shuman

RNA· April 2021

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Structure-function analysis of fission yeast cleavage and polyadenylation factor (CPF) subunit Ppn1 and its interactions with Dis2 and Swd22.
Bradley Benjamin, Ana M Sanchez, Angad Garg, Beate Schwer, Stewart Shuman

PLoS Genet· March 2021

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A genetic screen for suppressors of hyper-repression of the fission yeast PHO regulon by Pol2 CTD mutation T4A implicates inositol 1-pyrophosphates as agonists of precocious lncRNA transcription termination.
Angad Garg, Stewart Shuman, Beate Schwer

Nucleic Acids Res· November 2020

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