Publications by authors named "Beatriz A Castilho"

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Yeast as a Model to Understand Actin-Mediated Cellular Functions in Mammals-Illustrated with Four Actin Cytoskeleton Proteins.
Zain Akram, Ishtiaq Ahmed, Heike Mack, Ramandeep Kaur, Richard C Silva, Beatriz A Castilho

Cells· March 2020

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The GCN2 inhibitor IMPACT contributes to diet-induced obesity and body temperature control.
Catia M Pereira, Renato Filev, Francisco P Dubiela, Bruna B Brandão, Claudio M Queiroz, Beatriz A Castilho

PLoS One· February 2020

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Dietary sulfur amino acid restriction upregulates DICER to confer beneficial effects.
Beatriz A Guerra, Bruna B Brandão, Silas S Pinto, Willian G Salgueiro, Evandro A De-Souza, Beatriz A Castilho

Mol Metab· November 2019

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Topical Dexamethasone Administration Impairs Protein Synthesis and Neuronal Regeneration in the Olfactory Epithelium.
Umberto Crisafulli, André M Xavier, Fabiana B Dos Santos, Tavane D Cambiaghi, Seo Y Chang, Beatriz A Castilho

Front Mol Neurosci· March 2018

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A Rapid Extraction Method for mammalian cell cultures, suitable for quantitative immunoblotting analysis of proteins, including phosphorylated GCN2 and eIF2α.
Richard C Silva, Beatriz A Castilho, Evelyn Sattlegger

MethodsX· October 2017

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Phosphorylation of eIF2α on Threonine 169 is not required for Trypanosoma brucei cell cycle arrest during differentiation.
Carla Cristi D C Avila, Lori Peacock, Fabricio Castro Machado, Wendy Gibson, Sergio Schenkman, Beatriz A Castilho

Mol Biochem Parasitol· December 2016

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Perturbations in actin dynamics reconfigure protein complexes that modulate GCN2 activity and promote an eIF2 response.
Richard C Silva, Evelyn Sattlegger, Beatriz A Castilho

J Cell Sci· December 2016

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IMPACT is a GCN2 inhibitor that limits lifespan in Caenorhabditis elegans.
Rafael C Ferraz, Henrique Camara, Evandro A De-Souza, Silas Pinto, Ana Paula F Pinca, Beatriz A Castilho

BMC Biol· October 2016

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The Gcn2 Regulator Yih1 Interacts with the Cyclin Dependent Kinase Cdc28 and Promotes Cell Cycle Progression through G2/M in Budding Yeast.
Richard C Silva, Martina Dautel, Bruno M Di Genova, David C Amberg, Beatriz A Castilho

PLoS One· April 2016

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A membrane-bound eIF2 alpha kinase located in endosomes is regulated by heme and controls differentiation and ROS levels in Trypanosoma cruzi.
Leonardo da Silva Augusto, Nilmar Silvio Moretti, Thiago Cesar Prata Ramos, Teresa Cristina Leandro de Jesus, Min Zhang, Beatriz A Castilho

PLoS Pathog· February 2015

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Keeping the eIF2 alpha kinase Gcn2 in check.
Beatriz A Castilho, Renuka Shanmugam, Richard C Silva, Rashmi Ramesh, Benjamin M Himme

Biochim Biophys Acta· September 2014

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GCN2 kinase plays an important role triggering the remission phase of experimental autoimmune encephalomyelitis (EAE) in mice.
Heloisa Orsini, Leandro P Araujo, Juliana T Maricato, Marcia G Guereschi, Mario Mariano, Beatriz A Castilho

Brain Behav Immun· March 2014

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Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2.
Tavane D Cambiaghi, Catia M Pereira, Renuka Shanmugam, Michael Bolech, Ronald C Wek, Beatriz A Castilho

Biochem Biophys Res Commun· January 2014

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Eukaryotic initiation factor 5A dephosphorylation is required for translational arrest in stationary phase cells.
Janete Chung, Antonio A Rocha, Renata R Tonelli, Beatriz A Castilho, Sergio Schenkman

Biochem J· April 2013

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IMPACT is a developmentally regulated protein in neurons that opposes the eukaryotic initiation factor 2α kinase GCN2 in the modulation of neurite outgrowth.
Martín Roffé, Glaucia N M Hajj, Hátylas F Azevedo, Viviane S Alves, Beatriz A Castilho

J Biol Chem· April 2013

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Protein synthesis attenuation by phosphorylation of eIF2α is required for the differentiation of Trypanosoma cruzi into infective forms.
Renata R Tonelli, Leonardo da Silva Augusto, Beatriz A Castilho, Sergio Schenkman

PLoS One· May 2012

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Evidence that eukaryotic translation elongation factor 1A (eEF1A) binds the Gcn2 protein C terminus and inhibits Gcn2 activity.
Jyothsna Visweswaraiah, Sebastien Lageix, Beatriz A Castilho, Lara Izotova, Terri Goss Kinzy

J Biol Chem· October 2011

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Gcn1 and actin binding to Yih1: implications for activation of the eIF2 kinase GCN2.
Evelyn Sattlegger, João A R G Barbosa, Maria Carolina S Moraes, Rafael M Martins, Alan G Hinnebusch, Beatriz A Castilho

J Biol Chem· March 2011

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The NIP7 protein is required for accurate pre-rRNA processing in human cells.
Luis G Morello, Cédric Hesling, Patrícia P Coltri, Beatriz A Castilho, Ruth Rimokh

Nucleic Acids Res· January 2011

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Prion protein interaction with stress-inducible protein 1 enhances neuronal protein synthesis via mTOR.
Martín Roffé, Flávio Henrique Beraldo, Romina Bester, Max Nunziante, Christian Bach, Beatriz A Castilho

Proc Natl Acad Sci U S A· July 2010

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Characterization of the Trypanosoma cruzi ortholog of the SBDS protein reveals an intrinsically disordered extended C-terminal region showing RNA-interacting activity.
Juliana Ferreira de Oliveira, Beatriz A Castilho, Mauricio L Sforça, Marco Aurélio Krieger, Ana Carolina Zeri

Biochimie· April 2009

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Multiple RNAs from the mouse carboxypeptidase M locus: functional RNAs or transcription noise?
Alessander O Guimarães, Fabiana L Motta, Viviane S Alves, Beatriz A Castilho, João B Pesquero

BMC Mol Biol· February 2009

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GCN2 activation and eIF2alpha phosphorylation in the maturation of mouse oocytes.
Viviane S Alves, Fabiana L Motta, Martín Roffé, Arthur Delamano, João B Pesquero, Beatriz A Castilho

Biochem Biophys Res Commun· January 2009

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Distribution of the protein IMPACT, an inhibitor of GCN2, in the mouse, rat, and marmoset brain.
Simone Bittencourt, Catia M Pereira, Marcelo Avedissian, Arthur Delamano, Luiz E Mello, Beatriz A Castilho

J Comp Neurol· April 2008

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Novel membrane-bound eIF2alpha kinase in the flagellar pocket of Trypanosoma brucei.
Maria Carolina S Moraes, Teresa C L Jesus, Nilce N Hashimoto, Madhusudan Dey, Kevin J Schwartz, Beatriz A Castilho

Eukaryot Cell· November 2007

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