Publications by authors named "Ben G Small"

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Incorporation and Performance Verification of Hepatic Portal Blood Flow Shunting in Minimal and Full PBPK Models of Liver Cirrhosis.
Ben G Small, Oliver Hatley, Masoud Jamei, Iain Gardner, Trevor N Johnson

Clin Pharmacol Ther· December 2023

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Physiologically Based Pharmacokinetic Modelling to Predict Imatinib Exposures in Cancer Patients with Renal Dysfunction: A Case Study.
Karen Rowland Yeo, Oliver Hatley, Ben G Small, Trevor N Johnson

Pharmaceutics· July 2023

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Another Step Toward Qualification of Pediatric Physiologically Based Pharmacokinetic Models to Facilitate Inclusivity and Diversity in Pediatric Clinical Studies.
Ben G Small, Trevor N Johnson, Karen Rowland Yeo

Clin Pharmacol Ther· March 2023

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Development and application of a pediatric mechanistic kidney model.
Farzaneh Salem, Ben G Small, Trevor N Johnson

CPT Pharmacometrics Syst Pharmacol· July 2022

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Increasing application of pediatric physiologically based pharmacokinetic models across academic and industry organizations.
Trevor N Johnson, Ben G Small, Karen Rowland Yeo

CPT Pharmacometrics Syst Pharmacol· March 2022

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A best practice framework for applying physiologically-based pharmacokinetic modeling to pediatric drug development.
Trevor N Johnson, Ben G Small, Eva Gil Berglund, Karen Rowland Yeo

CPT Pharmacometrics Syst Pharmacol· September 2021

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Integration of Omics Data Sources to Inform Mechanistic Modeling of Immune-Oncology Therapies: A Tutorial for Clinical Pharmacologists.
Georgia Lazarou, Vijayalakshmi Chelliah, Ben G Small, Michael Walker, Piet H van der Graaf

Clin Pharmacol Ther· April 2020

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A Quantitative Systems Pharmacology Consortium Approach to Managing Immunogenicity of Therapeutic Proteins.
Andrzej M Kierzek, Timothy P Hickling, Isabel Figueroa, J Cory Kalvass, Marjoleen Nijsen, Ben G Small

CPT Pharmacometrics Syst Pharmacol· November 2019

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Prediction of liver volume - a population-based approach to meta-analysis of paediatric, adult and geriatric populations - an update.
Ben G Small, Bernd Wendt, Masoud Jamei, Trevor N Johnson

Biopharm Drug Dispos· May 2017

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Early assessment of proarrhythmic risk of drugs using the in vitro data and single-cell-based in silico models: proof of concept.
Mitra Abbasi, Ben G Small, Nikunjkumar Patel, Masoud Jamei, Sebastian Polak

Toxicol Mech Methods· February 2017

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Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing.
Ben G Small, Barry W McColl, Richard Allmendinger, Jürgen Pahle, Gloria López-Castejón

Nat Chem Biol· October 2011

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Validation of a voltage-sensitive dye (di-4-ANEPPS)-based method for assessing drug-induced delayed repolarisation in beagle dog left ventricular midmyocardial myocytes.
Matthew E L Hardy, Chris E Pollard, Ben G Small, Matthew Bridgland-Taylor, Ann J Woods

J Pharmacol Toxicol Methods· January 2010

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Gender differences in the slow delayed (IKs) but not in inward (IK1) rectifier K+ currents of canine Purkinje fibre cardiac action potential: key roles for IKs, beta-adrenoceptor stimulation, pacing rate and gender.
Najah Abi-Gerges, Ben G Small, Chris L Lawrence, Tim G Hammond, Jean-Pierre Valentin

Br J Pharmacol· March 2006

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Evidence for gender differences in electrophysiological properties of canine Purkinje fibres.
Najah Abi-Gerges, Ben G Small, Chris L Lawrence, Tim G Hammond, Jean-Pierre Valentin

Br J Pharmacol· August 2004

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