Publications by authors named "Benoit Ledoussal"

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Biological and Structural Analyses of New Potent Allosteric Inhibitors of HIV-1 Integrase.
Damien Bonnard, Erwann Le Rouzic, Matthew R Singer, Zhe Yu, Frédéric Le Strat, Benoit Ledoussal

Antimicrob Agents Chemother· July 2023

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Structural Basis for E. coli Penicillin Binding Protein (PBP) 2 Inhibition, a Platform for Drug Design.
Nicolas Levy, Jean-Michel Bruneau, Erwann Le Rouzic, Damien Bonnard, Frédéric Le Strat, Benoît Ledoussal

J Med Chem· May 2019

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Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration.
Damien Bonnard, Erwann Le Rouzic, Sylvia Eiler, Céline Amadori, Igor Orlov, Benoit Ledoussal

J Biol Chem· April 2018

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The HIV-1 integrase-LEDGF allosteric inhibitor MUT-A: resistance profile, impairment of virus maturation and infectivity but without influence on RNA packaging or virus immunoreactivity.
Céline Amadori, Yme Ubeles van der Velden, Damien Bonnard, Igor Orlov, Nikki van Bel, Benoit Ledoussal

Retrovirology· November 2017

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Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage.
Erwann Le Rouzic, Damien Bonnard, Sophie Chasset, Jean-Michel Bruneau, Francis Chevreuil, Benoit Ledoussal

Retrovirology· November 2013

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Vectorization efforts to increase Gram-negative intracellular drug concentration: a case study on HldE-K inhibitors.
Dmytro Atamanyuk, Fabien Faivre, Mayalen Oxoby, Benoit Ledoussal, Elodie Drocourt

J Med Chem· March 2013

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Unique biological properties and molecular mechanism of 5,6-bridged quinolones.
David R Macinga, Paul J Renick, Kelly M Makin, David H Ellis, Allison A Kreiner, Benoit Ledoussal

Antimicrob Agents Chemother· August 2003

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Discovery of (3S)-amino-(4R)-ethylpiperidinyl quinolones as potent antibacterial agents with a broad spectrum of activity and activity against resistant pathogens.
X Eric Hu, Nick K Kim, Jeffrey L Gray, Ji-In K Almstead, William L Seibel, Benoit Ledoussal

J Med Chem· August 2003

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Synthesis and biological testing of non-fluorinated analogues of levofloxacin.
Jeffrey L Gray, Ji In K Almstead, Corey P Gallagher, X Eric Hu, Nick K Kim, Benoit Ledoussal

Bioorg Med Chem Lett· July 2003

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Synthesis of trans-(3S)-amino-(4R)-alkyl- and -(4S)-aryl-piperidines via ring-closing metathesis reaction.
X Eric Hu, Nick K Kim, Benoit Ledoussal

Org Lett· December 2002

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Non-fluorinated quinolones (NFQs): new antibacterials with unique properties against quinolone-resistant gram-positive pathogens.
Siddhartha Roychoudhury, Benoit Ledoussal

Curr Drug Targets Infect Disord· March 2002

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