Publications by authors named "Bindu Goyal"

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Discovery of GS-7682, a Novel 4'-Cyano-Modified -Nucleoside Prodrug with Broad Activity against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys.
Dustin S Siegel, Hon C Hui, Jared Pitts, Meghan S Vermillion, Kazuya Ishida, Bindu Goyal

J Med Chem· August 2024

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Prodrugs of a 1'-CN-4-Aza-7,9-dideazaadenosine -Nucleoside Leading to the Discovery of Remdesivir (GS-5734) as a Potent Inhibitor of Respiratory Syncytial Virus with Efficacy in the African Green Monkey Model of RSV.
Richard L Mackman, Hon C Hui, Michel Perron, Eisuke Murakami, Christopher Palmiotti, Bindu Goyal

J Med Chem· April 2021

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Antitumor activity of the glutaminase inhibitor CB-839 in triple-negative breast cancer.
Matt I Gross, Susan D Demo, Jennifer B Dennison, Lijing Chen, Tania Chernov-Rogan, Bindu Goyal

Mol Cancer Ther· April 2014

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Development of indole/indazole-aminopyrimidines as inhibitors of c-Jun N-terminal kinase (JNK): optimization for JNK potency and physicochemical properties.
Leyi Gong, Xiaochun Han, Tania Silva, Yun-Chou Tan, Bindu Goyal

Bioorg Med Chem Lett· June 2013

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Development of amino-pyrimidine inhibitors of c-Jun N-terminal kinase (JNK): kinase profiling guided optimization of a 1,2,3-benzotriazole lead.
Wylie S Palmer, Muzaffar Alam, Humberto B Arzeno, Kung-Ching Chang, James P Dunn, Bindu Goyal

Bioorg Med Chem Lett· March 2013

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Discovery of novel PI3-kinase δ specific inhibitors for the treatment of rheumatoid arthritis: taming CYP3A4 time-dependent inhibition.
Brian S Safina, Stewart Baker, Matt Baumgardner, Paul M Blaney, Bryan K Chan, Bindu Goyal

J Med Chem· June 2012

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Novel pyrrolo[2,1-f][1,2,4]triazin-4-amines: Dual inhibitors of EGFR and HER2 protein tyrosine kinases.
Brian E Fink, Derek Norris, Harold Mastalerz, Ping Chen, Bindu Goyal

Bioorg Med Chem Lett· January 2011

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Discovery and preclinical evaluation of [4-[[1-(3-fluorophenyl)methyl]-1H-indazol-5-ylamino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamic acid, (3S)-3-morpholinylmethyl ester (BMS-599626), a selective and orally efficacious inhibitor of human epidermal growth factor receptor 1 and 2 kinases.
Ashvinikumar V Gavai, Brian E Fink, David J Fairfax, Gregory S Martin, Lana M Rossiter, Bindu Goyal

J Med Chem· November 2009

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Pyrimidine-based inhibitors of CaMKIIdelta.
Babu Mavunkel, Yong-Jin Xu, Bindu Goyal, Don Lim, Qing Lu

Bioorg Med Chem Lett· April 2008

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New C-5 substituted pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases.
Harold Mastalerz, Ming Chang, Ping Chen, Pierre Dextraze, Brian E Fink, Bindu Goyal

Bioorg Med Chem Lett· April 2007

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Identification of a novel series of tetrahydrodibenzazocines as inhibitors of 17beta-hydroxysteroid dehydrogenase type 3.
Brian E Fink, Ashvinikumar V Gavai, John S Tokarski, Bindu Goyal, Raj Misra

Bioorg Med Chem Lett· March 2006

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Synthesis and SAR of 4-(3-hydroxyphenylamino)pyrrolo[2,1-f][1,2,4]triazine based VEGFR-2 kinase inhibitors.
Robert M Borzilleri, Zhen-Wei Cai, Christopher Ellis, Joseph Fargnoli, Aberra Fura, Bindu Goyal

Bioorg Med Chem Lett· March 2005

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