Publications by authors named "Birgit Krewer"

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Glycosidic prodrugs of highly potent bifunctional duocarmycin derivatives for selective treatment of cancer.
Lutz F Tietze, J Marian von Hof, Michael Müller, Birgit Krewer, Ingrid Schuberth

Angew Chem Int Ed Engl· September 2010

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Synthesis of the first spacer containing prodrug of a duocarmycin analogue and determination of its biological activity.
Heiko J Schuster, Birgit Krewer, J Marian von Hof, Kianga Schmuck, Ingrid Schuberth

Org Biomol Chem· April 2010

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Determination of the biological activity and structure activity relationships of drugs based on the highly cytotoxic duocarmycins and CC-1065.
Lutz F Tietze, Birgit Krewer, J Marian von Hof, Holm Frauendorf, Ingrid Schuberth

Toxins (Basel)· December 2009

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Investigation of the transformations of a novel anti-cancer agent combining HPLC, HPLC-MS and direct ESI-HRMS analyses.
Lutz F Tietze, Birgit Krewer, Holm Frauendorf

Anal Bioanal Chem· September 2009

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Antibody-directed enzyme prodrug therapy: a promising approach for a selective treatment of cancer based on prodrugs and monoclonal antibodies.
Lutz F Tietze, Birgit Krewer

Chem Biol Drug Des· September 2009

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CD-spectroscopy as a powerful tool for investigating the mode of action of unmodified drugs in live cells.
Lutz F Tietze, Birgit Krewer, Felix Major, Ingrid Schuberth

J Am Chem Soc· September 2009

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Novel analogues of CC-1065 and the duocarmycins for the use in targeted tumour therapies.
Lutz F Tietze, Birgit Krewer

Anticancer Agents Med Chem· March 2009

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Synthesis and biological studies of different duocarmycin based glycosidic prodrugs for their use in the antibody-directed enzyme prodrug therapy.
Lutz F Tietze, Heiko J Schuster, Birgit Krewer, Ingrid Schuberth

J Med Chem· January 2009

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Asymmetric synthesis and biological evaluation of glycosidic prodrugs for a selective cancer therapy.
Lutz F Tietze, J Marian von Hof, Birgit Krewer, Michael Müller, Felix Major

ChemMedChem· December 2008

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Synthesis of a novel pentagastrin-drug conjugate for a targeted tumor therapy.
Lutz F Tietze, Olaf Panknin, Felix Major, Birgit Krewer

Chemistry· June 2008

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Synthesis and biological evaluation of a novel pentagastrin-toxin conjugate designed for a targeted prodrug mono-therapy of cancer.
Lutz F Tietze, Olaf Panknin, Birgit Krewer, Felix Major, Ingrid Schuberth

Int J Mol Sci· May 2008

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Selective treatment of cancer: synthesis, biological evaluation and structural elucidation of novel analogues of the antibiotic CC-1065 and the duocarmycins.
Lutz F Tietze, Felix Major, Ingrid Schuberth, Dirk A Spiegl, Birgit Krewer

Chemistry· August 2007

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Investigation of reactivity and selectivity of DNA-alkylating duocarmycin analogues by high-resolution mass spectrometry.
Lutz F Tietze, Birgit Krewer, Holm Frauendorf, Felix Major, Ingrid Schuberth

Angew Chem Int Ed Engl· October 2006

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