Publications by authors named "Bob D Brown"

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RNAi mediated silencing of STAT3/PD-L1 in tumor-associated immune cells induces robust anti-tumor effects in immunotherapy resistant tumors.
Shanthi Ganesh, Min Ju Kim, Jenny Lee, Xudong Feng, Krisjanis Ule, Bob D Brown

Mol Ther· June 2024

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First-in-human randomized study of RNAi therapeutic RG6346 for chronic hepatitis B virus infection.
Edward J Gane, Won Kim, Tien Huey Lim, Pisit Tangkijvanich, Jung-Hwan Yoon, Bob D Brown

J Hepatol· November 2023

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Therapeutic RNA interference: A novel approach to the treatment of primary hyperoxaluria.
Thomas A Forbes, Bob D Brown, Chengjung Lai

Br J Clin Pharmacol· June 2022

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Hepatic Lactate Dehydrogenase A: An RNA Interference Target for the Treatment of All Known Types of Primary Hyperoxaluria.
Gema Ariceta, Kelly Barrios, Bob D Brown, Bernd Hoppe, Ralf Rosskamp

Kidney Int Rep· April 2021

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Direct Inhibition of β-catenin: A new strategy for colorectal cancer.
Shanthi Ganesh, Bob D Brown, Marc Abrams

Oncoscience· January 2019

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RNAi-Mediated β-Catenin Inhibition Promotes T Cell Infiltration and Antitumor Activity in Combination with Immune Checkpoint Blockade.
Shanthi Ganesh, Xue Shui, Kevin P Craig, Jihye Park, Weimin Wang, Bob D Brown

Mol Ther· November 2018

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Specific Inhibition of Hepatic Lactate Dehydrogenase Reduces Oxalate Production in Mouse Models of Primary Hyperoxaluria.
Chengjung Lai, Natalie Pursell, Jessica Gierut, Utsav Saxena, Wei Zhou, Bob D Brown

Mol Ther· August 2018

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Inhibition of Glycogen Synthase II with RNAi Prevents Liver Injury in Mouse Models of Glycogen Storage Diseases.
Natalie Pursell, Jessica Gierut, Wei Zhou, Michael Dills, Rohan Diwanji, Bob D Brown

Mol Ther· July 2018

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β-Catenin mRNA Silencing and MEK Inhibition Display Synergistic Efficacy in Preclinical Tumor Models.
Shanthi Ganesh, Xue Shui, Kevin P Craig, Martin L Koser, Girish R Chopda, Bob D Brown

Mol Cancer Ther· February 2018

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Direct Pharmacological Inhibition of β-Catenin by RNA Interference in Tumors of Diverse Origin.
Shanthi Ganesh, Martin L Koser, Wendy A Cyr, Girish R Chopda, Junyan Tao, Bob D Brown

Mol Cancer Ther· September 2016

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Inhibition of Glycolate Oxidase With Dicer-substrate siRNA Reduces Calcium Oxalate Deposition in a Mouse Model of Primary Hyperoxaluria Type 1.
Chaitali Dutta, Nicole Avitahl-Curtis, Natalie Pursell, Marita Larsson Cohen, Benjamin Holmes, Bob D Brown

Mol Ther· April 2016

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Knockdown of β-catenin with dicer-substrate siRNAs reduces liver tumor burden in vivo.
Henryk Dudek, Darren H Wong, Rokhand Arvan, Anee Shah, Kathleen Wortham, Bob D Brown

Mol Ther· January 2014

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Quantitative analysis of dicer substrate oligonucleotides in mouse liver by ultra-high-performance liquid chromatography-electrospray ionization tandem mass spectrometry.
Kaisheng Jiao, Aftab Rashid, Sujit K Basu, Shuhao Zhu, Bob D Brown

Assay Drug Dev Technol· June 2012

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Glutathione and Bcl-2 targeting facilitates elimination by chemoradiotherapy of human A375 melanoma xenografts overexpressing bcl-xl, bcl-2, and mcl-1.
Salvador Mena, María L Rodriguez, Angel Ortega, Sonia Priego, Elena Obrador, Bob D Brown

J Transl Med· January 2012

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Inhibition of BCL-2 in small cell lung cancer cell lines with oblimersen, an antisense BCL-2 oligodeoxynucleotide (ODN): in vitro and in vivo enhancement of radiation response.
Yohann Loriot, Pierre Mordant, Bob D Brown, Jean Bourhis, Jean-Charles Soria

Anticancer Res· October 2010

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Downregulation of BCL-2 induces downregulation of carbonic anhydrase IX, vascular endothelial growth factor, and pAkt and induces radiation sensitization.
Satoshi Anai, Kathleen Shiverick, Theresa Medrano, Kogenta Nakamura, Steve Goodison, Bob D Brown

Urology· October 2007

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Irradiation of human prostate cancer cells increases uptake of antisense oligodeoxynucleotide.
Satoshi Anai, Bob D Brown, Kogenta Nakamura, Steve Goodison, Yoshihiko Hirao

Int J Radiat Oncol Biol Phys· July 2007

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Bcl-2 and glutathione depletion sensitizes B16 melanoma to combination therapy and eliminates metastatic disease.
Salvador Mena, María Benlloch, Angel Ortega, Julian Carretero, Elena Obrador, Bob D Brown

Clin Cancer Res· May 2007

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Comparison of d-g3139 and its enantiomer L-g3139 in melanoma cells demonstrates minimal in vitro but dramatic in vivo chiral dependency.
Johnathan C Lai, Bob D Brown, Anatoliy M Voskresenskiy, Stefan Vonhoff, Sven Klussman

Mol Ther· February 2007

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Knock-down of Bcl-2 by antisense oligodeoxynucleotides induces radiosensitization and inhibition of angiogenesis in human PC-3 prostate tumor xenografts.
Satoshi Anai, Steve Goodison, Kathleen Shiverick, Yoshihiko Hirao, Bob D Brown

Mol Cancer Ther· January 2007

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Bcl-2 protein in 518A2 melanoma cells in vivo and in vitro.
Luba Benimetskaya, Kanyalakshmi Ayyanar, Noah Kornblum, Daniela Castanotto, John Rossi, Bob D Brown

Clin Cancer Res· August 2006

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