Publications by authors named "Boxun Lu"

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R406 and its structural analogs reduce SNCA/α-synuclein levels via autophagic degradation.
Chao Zhong, Xiaoge Gao, Qi Chen, Bowen Guan, Wanli Wu, Boxun Lu

Autophagy· September 2025

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Lipid droplet clearance inhibits esophageal cancer growth via metabolic reprogramming.
Yan Pu, Yi Wan, Yuhua Fu, Kai Li, Yijiao Chen, Boxun Lu

Sci Bull (Beijing)· September 2025

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Post-translational modifications orchestrate the intrinsic signaling bias of GPR52.
Bingjie Zhang, Wei Ge, Mengna Ma, Shanshan Li, Jie Yu, Boxun Lu

Nat Chem Biol· August 2025

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MEK1/2 inhibitors suppress pathological α-synuclein and neurotoxicity in cell models and a humanized mouse model of Parkinson's disease.
Huilan Wang, Qing Wang, Haoxiang Xu, Yuanzheng Wu, Siulam Cheung, Boxun Lu

Sci Transl Med· May 2025

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Neuronal FAM171A2 mediates α-synuclein fibril uptake and drives Parkinson's disease.
Kai-Min Wu, Qian-Hui Xu, Yi-Qi Liu, Yi-Wei Feng, Si-Da Han, Bo-Xun Lu

Science· February 2025

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α-Synuclein amyloid fibril directly binds to LC3B and suppresses SQSTM1/p62-mediated selective autophagy.
Qianhui Xu, Huilan Wang, Ruonan Yang, Youqi Tao, Ziying Wang, Boxun Lu

Cell Res· January 2025

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Elevated IL-22 as a result of stress-induced gut leakage suppresses septal neuron activation to ameliorate anxiety-like behavior.
Mengyu Xia, Junmei Lu, Jiabin Lan, Teng Teng, Rani Shiao, Boxun Lu

Immunity· January 2025

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SnapShot: Targeted protein degradation.
Yu Ding, Boxun Lu

Cell· November 2024

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Biomolecular condensates and disease pathogenesis.
Ke Ruan, Ge Bai, Yanshan Fang, Dan Li, Tingting Li, Boxun Lu, Qing Lu

Sci China Life Sci· September 2024

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Excessive STAU1 condensate drives mTOR translation and autophagy dysfunction in neurodegeneration.
Ruiqian Zhao, Shijing Huang, Jingyu Li, Aihong Gu, Minjie Fu, Boxun Lu

J Cell Biol· August 2024

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Microglia contribute to polyG-dependent neurodegeneration in neuronal intranuclear inclusion disease.
Shaoping Zhong, Yangye Lian, Binbin Zhou, Ruiqing Ren, Lewei Duan, Boxun Lu

Acta Neuropathol· August 2024

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P53 upregulation by USP7-engaging molecular glues.
Zhaoyang Li, Ziying Wang, Chao Zhong, Hang Zhang, Rui Liu, Junmei Lu, Boxun Lu

Sci Bull (Beijing)· June 2024

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DDHD2, whose mutations cause spastic paraplegia type 54, enhances lipophagy via engaging ATG8 family proteins.
Fei Jia, Xiaoman Wang, Yuhua Fu, Shi-Min Zhao, Boxun Lu

Cell Death Differ· March 2024

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Discovery of SQSTM1/p62-dependent P-bodies that regulate the NLRP3 inflammasome.
Elizabeth R Barrow, Evelina Valionyte, Chris R Baxter, Yi Yang, Sharon Herath, Boxun Lu, Shouqing Luo

Cell Rep· March 2024

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Phase transition and lysosomal degradation of expanded CAG repeat RNA suppress global protein synthesis.
Junmei Lu, Yuyin Pan, Xinran Feng, Boxun Lu

Autophagy· February 2024

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Improved classification and pathogenicity assessment by comprehensive functional studies in a large data set of KCNQ2 variants.
Yuwei Zhang, Yuqing Xue, Yu Ma, Xiaonan Du, Boxun Lu

Life Sci· February 2024

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Targeted clearance of mitochondria by an autophagy-tethering compound (ATTEC) and its potential therapeutic effects.
Shuixia Tan, Da Wang, Yuhua Fu, Huiwen Zheng, Yan Liu, Boxun Lu

Sci Bull (Beijing)· December 2023

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MLKL deficiency alleviates neuroinflammation and motor deficits in the α-synuclein transgenic mouse model of Parkinson's disease.
Lu Geng, Wenqing Gao, Hexige Saiyin, Yuanyuan Li, Yu Zeng, Boxun Lu

Mol Neurodegener· December 2023

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Reduced lysosomal density in neuronal dendrites mediates deficits in synaptic plasticity in Huntington's disease.
Jia-Hui Chen, Na Xu, Lei Qi, Hao-Hao Yan, Fang-Yan Wan, Boxun Lu

Cell Rep· December 2023

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Gelation of cytoplasmic expanded CAG RNA repeats suppresses global protein synthesis.
Yuyin Pan, Junmei Lu, Xinran Feng, Shengyi Lu, Yi Yang, Shouqing Luo, Boxun Lu

Nat Chem Biol· November 2023

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Clearance of lipid droplets by chimeric autophagy-tethering compound ameliorates the age-related macular degeneration phenotype in mice lacking APOE.
Yuelu Zhang, Jiancheng Huang, Yu Liang, Jiaqiu Huang, Yuhua Fu, Boxun Lu

Autophagy· October 2023

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Targeting mitochondrial degradation by chimeric autophagy-tethering compounds.
Zhenqi Liu, Geng Qin, Jie Yang, Wenjie Wang, Wenting Zhang, Boxun Lu

Chem Sci· October 2023

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An Edge Transfer Learning Approach for Calibrating Soil Electrical Conductivity Sensors.
Yun-Wei Lin, Yi-Bing Lin, Ted C-Y Chang, Bo-Xun Lu

Sensors (Basel)· October 2023

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Drugging "undruggable" neurodegenerative disease targets with small molecules.
Junmei Lu, Zhaoyang Li, Aaron D Gitler, Boxun Lu

Sci Bull (Beijing)· August 2023

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The genetic spectrum of a cohort of patients clinically diagnosed as Parkinson's disease in mainland China.
Yi-Min Sun, Xin-Yue Zhou, Xiao-Niu Liang, Jin-Ran Lin, Yi-Dan Xu, Boxun Lu

NPJ Parkinsons Dis· May 2023

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