Publications by authors named "Brandon S Pybus"

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Potent Acridone Antimalarial against All Three Life Stages of .
Papireddy Kancharla, Rozalia A Dodean, Yuexin Li, Xiaowei Zhang, Sean Kelly, Brandon S Pybus

Res Sq· June 2025

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Development of Next-Generation Antimalarial Acridones with Radical Cure Potential.
Rozalia A Dodean, Yuexin Li, Xiaowei Zhang, Diana Caridha, Michael S Madejczyk, Brandon S Pybus

J Med Chem· April 2025

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Tambjamines as Fast-Acting Multistage Antimalarials.
Amrendra Kumar, Yuexin Li, Rozalia A Dodean, Alison Roth, Diana Caridha, Brandon S Pybus

ACS Infect Dis· December 2024

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Discovery and Optimization of Tambjamines as a Novel Class of Antileishmanial Agents.
Papireddy Kancharla, Diana Ortiz, Corinne M Fargo, Xiaowei Zhang, Yuexin Li, Brandon S Pybus

J Med Chem· May 2024

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Mechanisms of 8-aminoquinoline induced haemolytic toxicity in a G6PDd humanized mouse model.
Siobhan Flaherty, Pamela Strauch, Mahdi Maktabi, Brandon S Pybus, Gregory Reichard

J Cell Mol Med· July 2022

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Discovery of Imidazole-Based Inhibitors of cGMP-Dependent Protein Kinase.
Rammohan R Yadav Bheemanaboina, Mariana Laureano de Souza, Mariana Lozano Gonzalez, Shams Ul Mahmood, Tyler Eck, Brandon S Pybus

ACS Med Chem Lett· December 2021

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The fibrinolytic system enables the onset of infection in the mosquito vector and the mammalian host.
Thiago Luiz Alves E Silva, Andrea Radtke, Amanda Balaban, Tales Vicari Pascini, Zarna Rajeshkumar Pala, Brandon S Pybus

Sci Adv· February 2021

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Identification and Assessment of Plasmodium berghei Merozoites and Cell Cycle by Flow Cytometry.
Qigui Li, Lisa H Xie, Jing Zhang, Brandon S Pybus

Mil Med· January 2021

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Safety, Pharmacokinetics, and Activity of High-Dose Ivermectin and Chloroquine against the Liver Stage of Plasmodium cynomolgi Infection in Rhesus Macaques.
Pattaraporn Vanachayangkul, Rawiwan Im-Erbsin, Anchalee Tungtaeng, Chanikarn Kodchakorn, Alison Roth, Brandon S Pybus

Antimicrob Agents Chemother· August 2020

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Corrigendum to: Determination of Cytochrome P450 Isoenzyme 2D6 (CYP2D6) Genotypes and Pharmacogenomic Impact on Primaquine Metabolism in an Active-Duty US Military Population.
Michele D Spring, Jason C Sousa, Qigui Li, Christian A Darko, Meshell N Morrison, Brandon S Pybus

J Infect Dis· March 2020

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Determination of Cytochrome P450 Isoenzyme 2D6 (CYP2D6) Genotypes and Pharmacogenomic Impact on Primaquine Metabolism in an Active-Duty US Military Population.
Michele D Spring, Jason C Sousa, Qigui Li, Christian A Darko, Meshell N Morrison, Brandon S Pybus

J Infect Dis· October 2019

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Comparison of Anti-Xa Activity in Patients Receiving Apixaban or Rivaroxaban.
David A Bookstaver, Kimberly Sparks, Brandon S Pybus, Dustin K Davis, Sean R Marcsisin

Ann Pharmacother· March 2018

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Primaquine pharmacology in the context of CYP 2D6 pharmacogenomics: Current state of the art.
Sean R Marcsisin, Gregory Reichard, Brandon S Pybus

Pharmacol Ther· May 2016

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Pre-clinical evaluation of CYP 2D6 dependent drug-drug interactions between primaquine and SSRI/SNRI antidepressants.
Xiannu Jin, Brittney Potter, Thu-Lan Luong, Jennifer Nelson, Chau Vuong, Brandon S Pybus

Malar J· May 2016

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Differential cytochrome P450 2D metabolism alters tafenoquine pharmacokinetics.
Chau Vuong, Lisa H Xie, Brittney M J Potter, Jing Zhang, Ping Zhang, Brandon S Pybus

Antimicrob Agents Chemother· July 2015

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Comparison of MDCK-MDR1 and Caco-2 cell based permeability assays for anti-malarial drug screening and drug investigations.
Xiannu Jin, Thu-Lan Luong, Necole Reese, Heather Gaona, Vanessa Collazo-Velez, Brandon S Pybus

J Pharmacol Toxicol Methods· June 2015

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Investigation into novel thiophene- and furan-based 4-amino-7-chloroquinolines afforded antimalarials that cure mice.
Igor M Opsenica, Tatjana Ž Verbić, Mikloš Tot, Richard J Sciotti, Brandon S Pybus

Bioorg Med Chem· May 2015

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Differential CYP 2D6 metabolism alters primaquine pharmacokinetics.
Brittney M J Potter, Lisa H Xie, Chau Vuong, Jing Zhang, Ping Zhang, Brandon S Pybus

Antimicrob Agents Chemother· April 2015

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Enantioselective metabolism of primaquine by human CYP2D6.
Pius S Fasinu, Babu L Tekwani, N P Dhammika Nanayakkara, Bharathi Avula, H M T Bandara Herath, Brandon S Pybus

Malar J· December 2014

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Tafenoquine and NPC-1161B require CYP 2D metabolism for anti-malarial activity: implications for the 8-aminoquinoline class of anti-malarial compounds.
Sean R Marcsisin, Jason C Sousa, Gregory A Reichard, Diana Caridha, Qiang Zeng, Brandon S Pybus

Malar J· January 2014

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Primaquine failure and cytochrome P-450 2D6 in Plasmodium vivax malaria.
Jason W Bennett, Brandon S Pybus, Anjali Yadava, Donna Tosh, Jason C Sousa

N Engl J Med· October 2013

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The metabolism of primaquine to its active metabolite is dependent on CYP 2D6.
Brandon S Pybus, Sean R Marcsisin, Xiannu Jin, Gregory Deye, Jason C Sousa

Malar J· June 2013

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CYP450 phenotyping and metabolite identification of quinine by accurate mass UPLC-MS analysis: a possible metabolic link to blackwater fever.
Sean R Marcsisin, Xiannu Jin, Theresa Bettger, Nicholas McCulley, Jason C Sousa, Brandon S Pybus

Malar J· June 2013

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CYP450 phenotyping and accurate mass identification of metabolites of the 8-aminoquinoline, anti-malarial drug primaquine.
Brandon S Pybus, Jason C Sousa, Xiannu Jin, James A Ferguson, Robert E Christian

Malar J· August 2012

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