Publications by authors named "Brian Chait"

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A Nature-Inspired Ion Trap for Parallel Manipulation of Ions on a Massive Scale.
Andrew N Krutchinsky, Brian T Chait

bioRxiv· December 2025

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Karyopherins remodel the dynamic organization of the nuclear pore complex transport barrier.
Toshiya Kozai, Javier Fernandez-Martinez, Larisa E Kapinos, Paola Gallardo, Trevor van Eeuwen, Brian T Chait

Nat Cell Biol· December 2025

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Structural basis for Lamassu-based antiviral immunity and its evolution from DNA repair machinery.
Matthieu Haudiquet, Arpita Chakravarti, Zhiying Zhang, Josephine L Ramirez, Alba Herrero Del Valle, Brian T Chait

Proc Natl Acad Sci U S A· November 2025

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Distinct quaternary states, intermediates, and autoinhibition during loading of the DnaB-replicative helicase by the phage λP helicase loader.
Abhipsa Shatarupa, Dhanjai Brown, Paul Dominic B Olinares, Jillian Chase, Eta Isiorho, Brian T Chait

Nucleic Acids Res· November 2025

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Structural study on human microbiome-derived polyketide synthases that assemble genotoxic colibactin.
Minjae Kim, Jinwoo Kim, Gyu Sung Lee, Paul Dominic B Olinares, Yougant Airan, Brian T Chait

Structure· July 2025

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Distinct Quaternary States, Intermediates, and Autoinhibition During Loading of the DnaB-Replicative Helicase by the Phage λP Helicase Loader.
Abhipsa Shatarupa, Dhanjai Brown, Paul Dominic B Olinares, Jillian Chase, Eta Isiorho, Brian T Chait

bioRxiv· June 2025

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DnaB and DciA: mechanisms of helicase loading and translocation on ssDNA.
Nicholas Gao, Daniele Mazzoletti, Adele Peng, Paul Dominic B Olinares, Castrese Morrone, Brian T Chait

Nucleic Acids Res· June 2025

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DnaB and DciA: Mechanisms of Helicase Loading and Translocation on ssDNA.
Nicholas Gao, Daniele Mazzoletti, Adele Peng, Paul Dominic B Olinares, Castrese Morrone, Brian T Chait

bioRxiv· May 2025

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RapA opens the RNA polymerase clamp to disrupt post-termination complexes and prevent cytotoxic R-loop formation.
Joshua J Brewer, Koe Inlow, Rachel A Mooney, Barbara Bosch, Paul Dominic B Olinares, Brian T Chait

Nat Struct Mol Biol· April 2025

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Unique mechanisms to increase structural stability and enhance antigen binding in nanobodies.
Natalia E Ketaren, Peter C Fridy, Vladimir Malashkevich, Tanmoy Sanyal, Marc Brillantes, Brian T Chait

Structure· April 2025

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Structural basis for Lamassu-based antiviral immunity and its evolution from DNA repair machinery.
Matthieu Haudiquet, Arpita Chakravarti, Zhiying Zhang, Josephine L Ramirez, Alba Herrero Del Valle, Brian T Chait

bioRxiv· April 2025

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Exportin-1 functions as an adaptor for transcription factor-mediated docking of chromatin at the nuclear pore complex.
Tiffany Ge, Donna Garvey Brickner, Kara Zehr, D Jake VanBelzen, Wenzhu Zhang, Brian Chait

Mol Cell· March 2025

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KorB switching from DNA-sliding clamp to repressor mediates long-range gene silencing in a multi-drug resistance plasmid.
Thomas C McLean, Francisco Balaguer-Pérez, Joshua Chandanani, Christopher M Thomas, Clara Aicart-Ramos, Brian T Chait

Nat Microbiol· February 2025

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Targeted detection of endogenous LINE-1 proteins and ORF2p interactions.
Mathias I Nielsen, Justina C Wolters, Omar G Rosas Bringas, Hua Jiang, Luciano H Di Stefano, Brian T Chait

Mob DNA· February 2025

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A lineage-specific protein network at the trypanosome nuclear envelope.
Erin R Butterfield, Samson O Obado, Simon R Scutts, Wenzhu Zhang, Brian T Chait

Nucleus· December 2024

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Differential dynamics specify MeCP2 function at nucleosomes and methylated DNA.
Gabriella N L Chua, John W Watters, Paul Dominic B Olinares, Masuda Begum, Lauren E Vostal, Brian T Chait

Nat Struct Mol Biol· November 2024

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A new generation of nanobody research tools using improved mass spectrometry-based discovery methods.
Peter C Fridy, Ryan J Farrell, Kelly R Molloy, Sarah Keegan, Junjie Wang, Brian T Chait

J Biol Chem· September 2024

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Distinct modes of coupling between VCP, an essential unfoldase, and deubiquitinases.
Lauren E Vostal, Noa E Dahan, Wenzhu Zhang, Matthew J Reynolds, Brian T Chait

bioRxiv· September 2024

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Nanobody repertoire generated against the spike protein of ancestral SARS-CoV-2 remains efficacious against the rapidly evolving virus.
Natalia E Ketaren, Fred D Mast, Peter C Fridy, Jean Paul Olivier, Tanmoy Sanyal, Brian T Chait

Elife· May 2024

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Exportin-1 functions as an adaptor for transcription factor-mediated docking of chromatin at the nuclear pore complex.
Tiffany Ge, Donna Garvey Brickner, Kara Zehr, D Jake VanBelzen, Wenzhu Zhang, Brian Chait

bioRxiv· May 2024

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The Molecular Architecture of the Nuclear Basket.
Digvijay Singh, Neelesh Soni, Joshua Hutchings, Ignacia Echeverria, Farhaz Shaikh, Brian T Chait

bioRxiv· March 2024

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Using a Function-First "Scout Fragment"-Based Approach to Develop Allosteric Covalent Inhibitors of Conformationally Dynamic Helicase Mechanoenzymes.
Jared R Ramsey, Patrick M M Shelton, Tyler K Heiss, Paul Dominic B Olinares, Lauren E Vostal, Brian T Chait

J Am Chem Soc· January 2024

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Structural and functional insights into the enzymatic plasticity of the SARS-CoV-2 NiRAN domain.
Gabriel I Small, Olga Fedorova, Paul Dominic B Olinares, Joshua Chandanani, Anoosha Banerjee, Brian T Chait

Mol Cell· November 2023

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Using a function-first 'scout fragment'-based approach to develop allosteric covalent inhibitors of conformationally dynamic helicase mechanoenzymes.
Jared R Ramsey, Patrick M M Shelton, Tyler K Heiss, Paul Dominic B Olinares, Lauren E Vostal, Brian T Chait

bioRxiv· September 2023

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