Publications by authors named "Brian D Adair"

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Cryo-EM structures of full-length integrin αIIbβ3 in native lipids.
Brian D Adair, Jian-Ping Xiong, Mark Yeager, M Amin Arnaout

Nat Commun· July 2023

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Platelet integrin αIIbβ3 plays a key role in a venous thrombogenesis mouse model.
Brian D Adair, Conroy O Field, José L Alonso, Jian-Ping Xiong, Shi-Xian Deng

Nat Commun· October 2024

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Platelet integrin αIIbβ3 plays a key role in venous thrombogenesis in a mouse model.
Brian D Adair, Conroy O Field, José L Alonso, Jian-Ping Xiong, Shi-Xian Deng

bioRxiv· July 2024

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Structure-guided design of pure orthosteric inhibitors of αIIbβ3 that prevent thrombosis but preserve hemostasis.
Brian D Adair, José L Alonso, Johannes van Agthoven, Vincent Hayes, Hyun Sook Ahn

Nat Commun· January 2020

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Structural Basis of the Differential Binding of Engineered Knottins to Integrins αVβ3 and α5β1.
Johannes F Van Agthoven, Hengameh Shams, Frank V Cochran, José L Alonso, James R Kintzing, Brian D Adair

Structure· September 2019

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uPAR isoform 2 forms a dimer and induces severe kidney disease in mice.
Changli Wei, Jing Li, Brian D Adair, Ke Zhu, Jian Cai

J Clin Invest· April 2019

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Structure of the kidney slit diaphragm adapter protein CD2-associated protein as determined with electron microscopy.
Brian D Adair, Mehmet M Altintas, Clemens C Möller, M Amin Arnaout, Jochen Reiser

J Am Soc Nephrol· July 2014

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Atomic basis for the species-specific inhibition of αV integrins by monoclonal antibody 17E6 is revealed by the crystal structure of αVβ3 ectodomain-17E6 Fab complex.
Bhuvaneshwari Mahalingam, Johannes F Van Agthoven, Jian-Ping Xiong, José Luis Alonso, Brian D Adair

J Biol Chem· May 2014

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Structural basis for pure antagonism of integrin αVβ3 by a high-affinity form of fibronectin.
Johannes F Van Agthoven, Jian-Ping Xiong, José Luis Alonso, Xianliang Rui, Brian D Adair

Nat Struct Mol Biol· April 2014

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EM structure of the ectodomain of integrin CD11b/CD18 and localization of its ligand-binding site relative to the plasma membrane.
Brian D Adair, Jian-Ping Xiong, José Luis Alonso, Bradley T Hyman, M Amin Arnaout

PLoS One· August 2013

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Stable coordination of the inhibitory Ca2+ ion at the metal ion-dependent adhesion site in integrin CD11b/CD18 by an antibody-derived ligand aspartate: implications for integrin regulation and structure-based drug design.
Bhuvaneshwari Mahalingam, Kaouther Ajroud, José Luis Alonso, Saurabh Anand, Brian D Adair

J Immunol· December 2011

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Purification and electron cryomicroscopy of coronavirus particles.
Benjamin W Neuman, Brian D Adair, Mark Yeager, Michael J Buchmeier

Methods Mol Biol· March 2009

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Electron microscopy of integrins.
Brian D Adair, Mark Yeager

Methods Enzymol· October 2007

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Ultrastructure of SARS-CoV, FIPV, and MHV revealed by electron cryomicroscopy.
Benjamin W Neuman, Brian D Adair, Craig Yoshioka, Joel D Quispe, Ronald A Milligan

Adv Exp Med Biol· December 2006

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Supramolecular architecture of severe acute respiratory syndrome coronavirus revealed by electron cryomicroscopy.
Benjamin W Neuman, Brian D Adair, Craig Yoshioka, Joel D Quispe, Gretchen Orca

J Virol· August 2006

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Complementarity in the supramolecular design of arenaviruses and retroviruses revealed by electron cryomicroscopy and image analysis.
Benjamin W Neuman, Brian D Adair, John W Burns, Ronald A Milligan, Michael J Buchmeier

J Virol· March 2005

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Three-dimensional EM structure of the ectodomain of integrin {alpha}V{beta}3 in a complex with fibronectin.
Brian D Adair, Jian-Ping Xiong, Catherine Maddock, Simon L Goodman, M Amin Arnaout

J Cell Biol· March 2005

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Type IV pilin structure and assembly: X-ray and EM analyses of Vibrio cholerae toxin-coregulated pilus and Pseudomonas aeruginosa PAK pilin.
Lisa Craig, Ronald K Taylor, Michael E Pique, Brian D Adair, Andrew S Arvai

Mol Cell· May 2003

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Three-dimensional model of the human platelet integrin alpha IIbbeta 3 based on electron cryomicroscopy and x-ray crystallography.
Brian D Adair, Mark Yeager

Proc Natl Acad Sci U S A· October 2002

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