PubHawk
Nat Commun July 2023 PMID 37443315

Cryo-EM structures of full-length integrin αIIbβ3 in native lipids.

Brian D Adair, Jian-Ping Xiong, Mark Yeager, M Amin Arnaout

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Mentions

5
Peak: 3 in Jul 2023
across 2 sources since Jul 2023

Extended reach

3,253
potential audience

Total likes

2

Video views

41

Mentions per month

Jul 2023 – Oct 2023

Where it's discussed

  • X / Twitter4 posts
  • YouTube1 videos

AI synopsis

What people are saying

The discussions demonstrate a positive reception to the structural findings, with mentions of the cryo-EM approach and its contribution to understanding integrin function, exemplified by comments on the use of RRIDs to improve reproducibility. The tone is supportive and highlights the significance of this research as a step forward in structural biology.

AgreementModerate agreement

Most discussions express positive recognition of the research, highlighting its significance and support for the methodological advancements, such as the use of cryo-EM and RRIDs.

InterestHigh interest

The posts indicate high interest, with mentions of the new structural insights and their potential applications, showing enthusiasm for the scientific findings.

EngagementModerate engagement

While the posts are appreciative and informative, they mostly stay at a surface level, referencing methods and implications without deep technical analysis.

ImpactModerate impact

The posts suggest that the research is perceived as impactful, especially in terms of technological innovation and reproducibility, but without extensive commentary on broader implications.

Abstract in brief

  • *Anti-αIIbβ3 drugs like eptifibatide can prevent blood clots but may also hinder normal blood clotting functions.
  • *New cryo-EM structures reveal the full-length integrin's features, showing surprising accessibility of the ligand-binding site and significant changes when eptifibatide is bound, providing insights for safer drug development.*
Read the full abstract

Top posts

Most liked on X and Bluesky
Jon Humphries
@JDHL18 · X

Cryo-EM structures of full-length integrin αIIbβ3 in native lipids https://t.co/jhvWEBN9tT

Jul 16, 2023 · 1 like · 1 share · 2,505 followers View post →
Youzhong Guo
@youzhong · X

The NCMN system developed in my lab helped Prof. Amin Arnaout at Harvard University, solve the very challenging Cryo-EM structures of full-length integrin αIIbβ3 in native lipids. This work has been published in recent Nature Communications. https://t.co/kigOZ8kmYs

Aug 3, 2023 · 1 like · 17 followers View post →
Pereda Lab
@PeredaLab · X

RT @JDHL18: Cryo-EM structures of full-length integrin αIIbβ3 in native lipids https://t.co/jhvWEBN9tT

Jul 16, 2023 · 1 share · 526 followers View post →
RRID Robot
@RobotRrid · X

The authors of "Cryo-EM structures of full-length integrin αIIbβ3…" (https://t.co/fcdDW2mxpA) included RRIDs in their paper! RRIDs like this improve reproducibility in scientific research. #reproducibility #accelerateopenscience

Jul 16, 2023 · 161 followers View post →

All mentions

Youzhong Guo
@youzhong · X

The NCMN system developed in my lab helped Prof. Amin Arnaout at Harvard University, solve the very challenging Cryo-EM structures of full-length integrin αIIbβ3 in native lipids. This work has been published in recent Nature Communications. https://t.co/kigOZ8kmYs

Aug 3, 2023 · 1 like · 17 followers View post →
Pereda Lab
@PeredaLab · X

RT @JDHL18: Cryo-EM structures of full-length integrin αIIbβ3 in native lipids https://t.co/jhvWEBN9tT

Jul 16, 2023 · 1 share · 526 followers View post →
Jon Humphries
@JDHL18 · X

Cryo-EM structures of full-length integrin αIIbβ3 in native lipids https://t.co/jhvWEBN9tT

Jul 16, 2023 · 1 like · 1 share · 2,505 followers View post →
RRID Robot
@RobotRrid · X

The authors of "Cryo-EM structures of full-length integrin αIIbβ3…" (https://t.co/fcdDW2mxpA) included RRIDs in their paper! RRIDs like this improve reproducibility in scientific research. #reproducibility #accelerateopenscience

Jul 16, 2023 · 161 followers View post →