Cryo-EM structures of full-length integrin αIIbβ3 in native lipids.

Brian D Adair, Jian-Ping Xiong, Mark Yeager, M Amin Arnaout

July 2023 Nat Commun

Synopsis of Social media discussions

The discussions demonstrate a positive reception to the structural findings, with mentions of the cryo-EM approach and its contribution to understanding integrin function, exemplified by comments on the use of RRIDs to improve reproducibility. The tone is supportive and highlights the significance of this research as a step forward in structural biology.

A
Agreement
 Moderate agreement

Most discussions express positive recognition of the research, highlighting its significance and support for the methodological advancements, such as the use of cryo-EM and RRIDs.

I
Interest
 High level of interest

The posts indicate high interest, with mentions of the new structural insights and their potential applications, showing enthusiasm for the scientific findings.

E
Engagement
 Moderate level of engagement

While the posts are appreciative and informative, they mostly stay at a surface level, referencing methods and implications without deep technical analysis.

I
Impact
 Moderate level of impact

The posts suggest that the research is perceived as impactful, especially in terms of technological innovation and reproducibility, but without extensive commentary on broader implications.

Social Mentions

YouTube

1 Videos

Twitter

4 Posts

Metrics

Video Views

41

Total Likes

2

Extended Reach

3,253

Social Features

5

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

Cryo-EM Structures of Full-Length Integrin αIIbβ3 in Native Membranes

Cryo-EM Structures of Full-Length Integrin αIIbβ3 in Native Membranes

This video discusses the cryo-EM structures of platelet integrin αIIbβ3 in their native lipid environment, revealing how these structures undergo significant conformational changes upon activation and drug binding, providing insights for safer therapeutic development.

STEM RTCL TV

October 18, 2023

41 views

  • Youzhong Guo
    @youzhong (Twitter)

    The NCMN system developed in my lab helped Prof. Amin Arnaout at Harvard University, solve the very challenging Cryo-EM structures of full-length integrin αIIbβ3 in native lipids. This work has been published in recent Nature Communications. https://t.co/kigOZ8kmYs
    view full post

    August 3, 2023

    1

  • Pereda Lab
    @PeredaLab (Twitter)

    RT @JDHL18: Cryo-EM structures of full-length integrin αIIbβ3 in native lipids https://t.co/jhvWEBN9tT
    view full post

    July 16, 2023

    1

  • Jon Humphries
    @JDHL18 (Twitter)

    Cryo-EM structures of full-length integrin αIIbβ3 in native lipids https://t.co/jhvWEBN9tT
    view full post

    July 16, 2023

    1

    1

  • RRID Robot
    @RobotRrid (Twitter)

    The authors of "Cryo-EM structures of full-length integrin αIIbβ3…" (https://t.co/fcdDW2mxpA) included RRIDs in their paper! RRIDs like this improve reproducibility in scientific research. #reproducibility #accelerateopenscience
    view full post

    July 16, 2023

Abstract Synopsis

  • *Anti-αIIbβ3 drugs like eptifibatide can prevent blood clots but may also hinder normal blood clotting functions.
  • *New cryo-EM structures reveal the full-length integrin's features, showing surprising accessibility of the ligand-binding site and significant changes when eptifibatide is bound, providing insights for safer drug development.*