Publications by authors named "Brian D Guth"

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Implementation of automated blood sampling in a canine cardiovascular safety pharmacology study to support PK/PD assessment.
Elham Ataei Alizadeh, Georg Rast, Jessica Schiwon, Thomas Trautmann, Chris Cantow, Brian D Guth

J Pharmacol Toxicol Methods· September 2025

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Optimization of bioanalysis of dried blood samples.
Elham Ataei Alizadeh, Georg Rast, Chris Cantow, Jessica Schiwon, Florian Krause, Brian D Guth

J Pharmacol Toxicol Methods· November 2023

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The impact of environmental and biological factors on the resting heart rate of dogs as assessed using 20 years of data from safety pharmacology studies.
Elham Ataei Alizadeh, Thomas Trautmann, Florian Krause, Benjamin Knoeferl, Pieter-Jan Guns, Brian D Guth

J Pharmacol Toxicol Methods· October 2023

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Thirty years of telemetry-based data acquisition for cardiovascular drug safety evaluation: Applications and optimization.
Elham Ataei Alizadeh, Karin Graf, Jessica Schiwon, Thomas Trautmann, Florian Krause, Brian D Guth

J Pharmacol Toxicol Methods· July 2023

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INSPIRE: A European training network to foster research and training in cardiovascular safety pharmacology.
Pieter-Jan D Guns, Brian D Guth, Stefan Braam, Georgios Kosmidis, Elena Matsa

J Pharmacol Toxicol Methods· September 2020

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Comparison of in vitro and computational experiments on the relation of inter-beat interval and duration of repolarization in a specific type of human induced pluripotent stem cell-derived cardiomyocytes.
Philipp Kügler, Georg Rast, Brian D Guth

PLoS One· March 2020

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Drug safety Africa: An overview of safety pharmacology & toxicology in South Africa.
Brian D Guth, Anne F Grobler, Kendall S Frazier, Andrea Greiter-Wilke, Danuta Herzyk

J Pharmacol Toxicol Methods· January 2020

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Considerations for an , Cell-Based Testing Platform for Detection of Adverse Drug-Induced Inotropic Effects in Early Drug Development. Part 1: General Considerations for Development of Novel Testing Platforms.
Brian D Guth, Michael Engwall, Sandy Eldridge, C Michael Foley, Liang Guo

Front Pharmacol· August 2019

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Considerations for an , Cell-Based Testing Platform for Detection of Drug-Induced Inotropic Effects in Early Drug Development. Part 2: Designing and Fabricating Microsystems for Assaying Cardiac Contractility With Physiological Relevance Using Human iPSC-Cardiomyocytes.
Alexandre J S Ribeiro, Brian D Guth, Michael Engwall, Sandy Eldridge, C Michael Foley

Front Pharmacol· August 2019

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A new telemetry-based system for assessing cardiovascular function in group-housed large animals. Taking the 3Rs to a new level with the evaluation of remote measurement via cloud data transmission.
Michael Markert, Thomas Trautmann, Florian Krause, Marius Cioaga, Sebastien Mouriot, Brian D Guth

J Pharmacol Toxicol Methods· January 2019

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Safety pharmacology in and for Africa: Establishment of the pre-clinical drug development platform.
Brian D Guth, Anne Grobler

J Pharmacol Toxicol Methods· January 2019

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The evaluation of endpoint variability and implications for study statistical power and sample size in conscious instrumented dogs.
Alan Y Chiang, Brian D Guth, Michael K Pugsley, C Michael Foley, Jennifer M Doyle

J Pharmacol Toxicol Methods· October 2018

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GLP in safety pharmacology studies: Report card after 15years.
Brian D Guth, Michael K Pugsley

J Pharmacol Toxicol Methods· September 2017

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Influence of field potential duration on spontaneous beating rate of human induced pluripotent stem cell-derived cardiomyocytes: Implications for data analysis and test system selection.
Georg Rast, Udo Kraushaar, Sandra Buckenmaier, Carina Ittrich, Brian D Guth

J Pharmacol Toxicol Methods· May 2017

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The evaluation of drug-induced changes in cardiac inotropy in dogs: Results from a HESI-sponsored consortium.
Brian D Guth, Alan Y Chiang, Jennifer Doyle, Michael J Engwall, Jean-Michel Guillon

J Pharmacol Toxicol Methods· July 2016

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An integrated platform for simultaneous multi-well field potential recording and Fura-2-based calcium transient ratiometry in human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes.
Georg Rast, Jürgen Weber, Christoph Disch, Elmar Schuck, Carina Ittrich, Brian D Guth

J Pharmacol Toxicol Methods· July 2016

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Considerations for assessing the potential effects of antidiabetes drugs on cardiac ventricular repolarization: A report from the Cardiac Safety Research Consortium.
Simon Heller, Börje Darpö, Malcolm I Mitchell, Helle Linnebjerg, Derek J Leishman, Brian D Guth

Am Heart J· July 2015

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Solubility assessment and on-line exposure confirmation in a patch-clamp assay for hERG (human ether-a-go-go-related gene) potassium channel inhibition.
Georg Rast, Brian D Guth

J Pharmacol Toxicol Methods· June 2015

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Preclinical cardiovascular risk assessment in modern drug development.
Brian D Guth

Toxicol Sci· May 2007

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Short-term intra-arterial infusion of monocyte chemoattractant protein-1 results in sustained collateral artery growth.
Randolph W Seidler, Martin C Lenter, Brian D Guth, Henri Doods

J Cardiovasc Pharmacol Ther· March 2007

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Developing a strategy for the nonclinical assessment of proarrhythmic risk of pharmaceuticals due to prolonged ventricular repolarization.
Brian D Guth, Sabine Germeyer, Willi Kolb, Michael Markert

J Pharmacol Toxicol Methods· December 2004

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Pharmacokinetics and pharmacodynamics of terbogrel, a combined thromboxane A2 receptor and synthase inhibitor, in healthy subjects.
Brian D Guth, Hans Narjes, Hans-Dieter Schubert, Paul Tanswell, Axel Riedel

Br J Clin Pharmacol· July 2004

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Modulation of collateral artery growth in a porcine hindlimb ligation model using MCP-1.
Michiel Voskuil, Niels van Royen, Imo E Hoefer, Randolph Seidler, Brian D Guth

Am J Physiol Heart Circ Physiol· April 2003

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