Publications by authors named "Brian Hardy"

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A host-directed adjuvant sensitizes intracellular bacterial persisters to antibiotics.
Kuan-Yi Lu, Xiangbo Yang, Matthew J G Eldridge, Rongfeng Sun, Rachel T Giorgio, Brian Hardy

Nat Microbiol· November 2025

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Expansion of DNA-Encoded Library Hits Using Generative Chemistry and Ultra-Large Compound Catalogs.
Brandon Novy, Shu-Hang Lin, Devan J Shell, Travis Maxfield, Eric M Merten, P Brian Hardy

bioRxiv· October 2025

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Open-Source DNA-Encoded Library informatics Package for Design, Decoding, and Analysis: DELi.
James Wellnitz, Brandon Novy, Travis Maxfield, Shu-Hang Lin, Ivanna Zhilinskaya, Brian P Hardy

bioRxiv· September 2025

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Development of Next Generation Cell-Permeable Peptide Inhibitors for the Oncological Target MAGE-A4.
Jiwoong Lim, Lilly F Chiou, Brandon Novy, Emma J Chow, Jacqueline L Norris-Drouin, P Brian Hardy

J Med Chem· September 2025

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Subclinical gastrointestinal mucosal lesions occur in dogs with intrahepatic portosystemic shunts independent of percutaneous transvenous coil embolization.
Erin A Gibson, William T N Culp, Brian T Hardy, Michelle A Giuffrida, Ingrid M Balsa

J Am Vet Med Assoc· August 2025

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Non-Canonical, Strongly Selective Protein Disulfide Isomerases as Anticancer Therapeutic Targets.
Mary E Law, Zaafir M Dulloo, Brian Hardy, Ania Kelegama, Reagan Clark

Biomolecules· August 2025

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DR5 Disulfide Bonding Functions as a Sensor and Effector of Protein Folding Stress.
Mary E Law, Zaafir M Dulloo, Samantha R Eggleston, Gregory P Takacs, Grace M Alexandrow, Brian Hardy

Mol Cancer Res· July 2025

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A novel approach to nasopharyngoscopy in canine and feline cadavers: development and application of 3-dimensional-printed instrument guides.
Miruna Munteanu, Brian Hardy

Am J Vet Res· July 2025

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A high-throughput assay platform to discover small molecule activators of the phospholipase PLC-γ2 to treat Alzheimer's disease.
Adam J Carr, Nicole Hajicek, Andy P Tsai, Padam P Acharya, P Brian Hardy

J Biol Chem· April 2025

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A multi-kinase inhibitor screen identifies inhibitors preserving stem-cell-like chimeric antigen receptor T cells.
Feifei Song, Ourania Tsahouridis, Simone Stucchi, Tara Walhart, Sophie Mendell, P Brian Hardy

Nat Immunol· February 2025

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Patient-specific 3D-printed nasopharyngeal stents in dogs: a cadaveric pilot study.
Craig Sutter, Brian Hardy, Steven Lucero, Lynelle Johnson, William Culp

Front Vet Sci· November 2024

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Identification of a cell-active chikungunya virus nsP2 protease inhibitor using a covalent fragment-based screening approach.
Eric M Merten, John D Sears, Tina M Leisner, P Brian Hardy, Anirban Ghoshal

Proc Natl Acad Sci U S A· October 2024

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A host-directed adjuvant resuscitates and sensitizes intracellular bacterial persisters to antibiotics.
Kuan-Yi Lu, Xiangbo Yang, Matthew J G Eldridge, Nikki J Wagner, Brian Hardy

bioRxiv· October 2024

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A First-in-Class High-Throughput Screen to Discover Modulators of the Alternative Lengthening of Telomeres (ALT) Pathway.
Merrill M Froney, Christian R Cook, Alyssa M Cadiz, Katherine A Flinter, Sara T Ledeboer, Brian P Hardy

ACS Pharmacol Transl Sci· September 2024

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In silico fragment-based discovery of CIB1-directed anti-tumor agents by FRASE-bot.
Yi An, Jiwoong Lim, Marta Glavatskikh, Xiaowen Wang, Jacqueline Norris-Drouin, P Brian Hardy

Nat Commun· July 2024

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Discovery of a 53BP1 Small Molecule Antagonist Using a Focused DNA-Encoded Library Screen.
Devan J Shell, Caroline A Foley, Qinhong Wang, Chelsea M Smith, Shiva K R Guduru, P Brian Hardy

J Med Chem· October 2023

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Machine Learning-driven Fragment-based Discovery of CIB1-directed Anti-Tumor Agents by FRASE-bot.
Yi An, Marta Glavatskikh, Jiwoong Lim, Xiaowen Wang, Jacqueline Norris-Drouin, P Brian Hardy

Res Sq· August 2023

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Development of a high-throughput TR-FRET screening assay for a fast-cycling KRAS mutant.
Jacob E Larson, P Brian Hardy, Noah K Schomburg, Xiaodong Wang, Dmitri Kireev

SLAS Discov· January 2023

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Discovery of hit compounds for methyl-lysine reader proteins from a target class DNA-encoded library.
Devan J Shell, Justin M Rectenwald, Peter H Buttery, Rebecca L Johnson, Caroline A Foley, P Brian Hardy

SLAS Discov· December 2022

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Reprogramming CBX8-PRC1 function with a positive allosteric modulator.
Junghyun L Suh, Daniel Bsteh, Bryce Hart, Yibo Si, Tyler M Weaver, Brian Hardy

Cell Chem Biol· April 2022

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Use of AD Informer Set compounds to explore validity of novel targets in Alzheimer's disease pathology.
Frances M Potjewyd, Joel K Annor-Gyamfi, Jeffrey Aubé, Shaoyou Chu, Ivie L Conlon, Brian P Hardy

Alzheimers Dement (N Y)· April 2022

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AD Informer Set: Chemical tools to facilitate Alzheimer's disease drug discovery.
Frances M Potjewyd, Joel K Annor-Gyamfi, Jeffrey Aubé, Shaoyou Chu, Ivie L Conlon, Brian P Hardy

Alzheimers Dement (N Y)· April 2022

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Mandibular metastasis of a prostatic carcinoma in a dog.
Sarah R Michalak, Dennis J Woerde, Sabrina S Wilson, Flavio H Alonso, Brian T Hardy

Vet Med Sci· September 2021

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Precision medicine identifies a pathogenic variant of the ITGA2B gene responsible for Glanzmann's thrombasthenia in a cat.
Ronald H L Li, Eric Ontiveros, Nghi Nguyen, Joshua A Stern, Elizabeth Lee, Brian T Hardy

J Vet Intern Med· November 2020

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A High-Throughput Assay to Identify Allosteric Inhibitors of the PLC-γ Isozymes Operating at Membranes.
Weigang Huang, Adam J Carr, Nicole Hajicek, Miri Sokolovski, Edhriz Siraliev-Perez, P Brian Hardy

Biochemistry· October 2020

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