Publications by authors named "Brian Keyser"

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In vitro toxicological evaluation of nicotine concentration and flavor variants of Vuse Alto ENDS.
Brian M Keyser, Robert Leverette, Reagan McRae, John Wertman, Tom Shutsky

Food Chem Toxicol· October 2025

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Randomized clinical studies assessing the pharmacokinetics and subjective effects of vuse alto electronic nicotine delivery systems.
Kristen Prevette, Kristen G Jordan, Brian M Keyser, Milly N Kanobe, Tao Jin

Sci Rep· July 2025

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An adverse outcome pathway for cigarette smoke-mediated oxidative stress in plaque formation.
Patrudu Makena, Linsey E Haswell, Michael McEwan, Brian M Keyser, David E Smart

Front Toxicol· June 2025

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Randomized crossover clinical studies to assess abuse liability and nicotine pharmacokinetics of Velo Oral Nicotine pouches.
Milly N Kanobe, Christie Y Powell, Makena Patrudu, Sarah A Baxter, Melissa A Tapia, Brian M Keyser

Front Pharmacol· March 2025

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toxicological evaluation of pouched portioned oral nicotine products.
Brian M Keyser, Robert Leverette, Reagan McRae, John Wertman, Tom Shutsky

Front Toxicol· November 2024

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In vitro toxicological evaluation of glo menthol and non-menthol heated tobacco products.
Brian M Keyser, Robert Leverette, Reagan McRae, John Wertman, Tom Shutsky

Toxicology· May 2024

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In vitro permeation of nicotine and tobacco specific nitrosamines from smokeless tobacco product extracts in a 3D buccal tissue model.
Brian M Keyser, Hannah Flockton, Randy A Weidman, Rebecca Payne, Jannell Rowe

Toxicol Lett· February 2024

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Evaluation of Cytotoxicity and Oxidative Stress of Whole Aerosol from Vuse Alto ENDS Products.
Brian M Keyser, Robert Leverette, John Wertman, Tom Shutsky, Reagan McRae

Toxics· February 2024

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Part two: an unblinded, parallel, randomized study to assess nicotine pharmacokinetics of four Vuse Solo ENDS flavors in smokers.
Brian M Keyser, Kyung Soo Hong, Patricia DeLuca, Tao Jin, Bobbette A Jones

Sci Rep· June 2023

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Characterization of smoke and aerosol deliveries from combustible cigarettes, heated tobacco products and electronic nicotine delivery systems in the Vitrocell® Mammalian 6/48 exposure module.
Brian M Keyser, Robert Leverette, Michael Hollings, Adam Seymour, Randy A Weidman

Toxicol Rep· November 2022

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Ciliary Beat Frequency: Proceedings and Recommendations from a Multi-laboratory Ring Trial Using 3-D Reconstituted Human Airway Epithelium to Model Mucociliary Clearance.
Holger P Behrsing, Adam Wahab, Lindsey Ukishima, Chad Grodi, Stefan Frentzel, Brian M Keyser

Altern Lab Anim· July 2022

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Cytotoxicity, oxidative stress, and inflammatory response of smokeless tobacco extracts and cytotoxicity of combustible cigarette whole smoke in a 3D oral organotypic buccal cell model.
Brian M Keyser

Toxicol Mech Methods· June 2022

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Investigation of multiple whole smoke dosimetry techniques using a VITROCELL®VC10® smoke exposure system.
Brian M Keyser, Robert Leverette, Michael Hollings, Adam Seymour, Lesley Reeve

Toxicol Rep· November 2019

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Development of a quantitative method for assessment of dose in in vitro evaluations using a VITROCELL® VC10® smoke exposure system.
Brian M Keyser, Robert Leverette, Kathy Fowler, Wanda Fields, Victoria Hargreaves

Toxicol In Vitro· April 2019

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Pathway-based predictive approaches for non-animal assessment of acute inhalation toxicity.
Amy J Clippinger, David Allen, Holger Behrsing, Kelly A BéruBé, Michael B Bolger, Brian Keyser

Toxicol In Vitro· October 2018

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Apoptotic cell death in rat lung following mustard gas inhalation.
Devon K Andres, Brian M Keyser, Ashley A Melber, Betty J Benton, Tracey A Hamilton

Am J Physiol Lung Cell Mol Physiol· June 2017

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Transient receptor potential (TRP) channels as a therapeutic target for intervention of respiratory effects and lethality from phosgene.
Devon Andres, Brian Keyser, Betty Benton, Ashley Melber, Dorian Olivera

Toxicol Lett· February 2016

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Conceptual approaches for treatment of phosgene inhalation-induced lung injury.
Wesley W Holmes, Brian M Keyser, Danielle C Paradiso, Radharaman Ray, Devon K Andres

Toxicol Lett· February 2016

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Differentiated NSC-34 cells as an in vitro cell model for VX.
Baishali Kanjilal, Brian M Keyser, Devon K Andres, Eric Nealley, Betty Benton

Toxicol Mech Methods· October 2014

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Mustard Gas Inhalation Injury: Therapeutic Strategy.
Brian M Keyser, Devon K Andres, Wesley W Holmes, Danielle Paradiso, Ashley Appell

Int J Toxicol· July 2014

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Morphological and functional differentiation in BE(2)-M17 human neuroblastoma cells by treatment with Trans-retinoic acid.
Devon Andres, Brian M Keyser, John Petrali, Betty Benton, Kyle S Hubbard

BMC Neurosci· April 2013

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Postexposure application of Fas receptor small-interfering RNA to suppress sulfur mustard-induced apoptosis in human airway epithelial cells: implication for a therapeutic approach.
Brian M Keyser, Devon K Andres, Eric Nealley, Wesley W Holmes, Betty Benton

J Pharmacol Exp Ther· January 2013

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Sulfur mustard induces apoptosis in lung epithelial cells via a caspase amplification loop.
Radharaman Ray, Cynthia M Simbulan-Rosenthal, Brian M Keyser, Betty Benton, Dana Anderson

Toxicology· May 2010

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Selective blockade of T-type Ca2+ channels suppresses human breast cancer cell proliferation.
James T Taylor, Luping Huang, Jonathan E Pottle, Kai Liu, Yali Yang, Brian M Keyser

Cancer Lett· August 2008

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Sulfur mustard induces apoptosis in cultured normal human airway epithelial cells: evidence of a dominant caspase-8-mediated pathway and differential cellular responses.
Radharaman Ray, Brian Keyser, Betty Benton, Ahmad Daher, Cynthia M Simbulan-Rosenthal

Drug Chem Toxicol· February 2008

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