Publications by authors named "Brian Linehan"

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Discovery and development of BI 1265162, an ENaC inhibitor for the treatment of cystic fibrosis.
Bodo Betzemeier, Clemens Braun, Peter Sieger, Armin Heckel, Günter Linz, Brian Linehan

Eur J Med Chem· February 2024

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Terminal crystalline solid solutions, solubility enhancements and T-X phase diagram of salicylic acid - 4-hydroxybenzoic acid.
Yongjian Wang, Francesco Ricci, Brian Linehan, Fredrik L Nordstrom

Phys Chem Chem Phys· January 2024

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Enantiotropic inconstancy, crystalline solid solutions and co-crystal in the salicylic acid-anthranilic acid system.
Fredrik L Nordstrom, Seyed Sepehr Mohajerani, Brian Linehan, Francesco Ricci

Phys Chem Chem Phys· November 2022

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Cardiovascular safety pharmacology studies in dogs enabled for a poorly soluble molecule using spray-dried dispersion: Impact on lead selection.
Yin-Chao Tseng, Brian Linehan, Khing Jow Ng, Dustin M Smith, Michael Markert

Int J Pharm· October 2016

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Physical Properties and Effect in a Battery of Safety Pharmacology Models for Three Structurally Distinct Enteric Polymers Employed as Spray-Dried Dispersion Carriers.
Ryan M Fryer, Mita Patel, Xiaomei Zhang, Katja S Baum-Kroker, Akalushi Muthukumarana, Brian Linehan

Front Pharmacol· October 2016

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Late-stage optimization of a tercyclic class of S1P3-sparing, S1P1 receptor agonists.
Joshua C Horan, Daniel Kuzmich, Pingrong Liu, Darren DiSalvo, John Lord, Brian Linehan

Bioorg Med Chem Lett· January 2016

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Optimization of the Büchi B-90 spray drying process using central composite design for preparation of solid dispersions.
Bing Gu, Brian Linehan, Yin-Chao Tseng

Int J Pharm· August 2015

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A new combination approach of CI jet and QESD to formulate pH-susceptible amorphous solid dispersions.
Sumit Kumar, Brian Linehan, Yin-Chao Tseng

Int J Pharm· May 2014

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Aryl 1,4-diazepane compounds as potent and selective CB2 agonists: optimization of drug-like properties and target independent parameters.
Renée Zindell, Edward R Walker, John Scott, Patricia Amouzegh, Lifen Wu, Brian Linehan

Bioorg Med Chem Lett· July 2011

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