Publications by authors named "Brian Mark"

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Generation of mice with combined Hexa Gly269Ser KI or KO and Neu3 KO alleles to create new models of GM2 gangliosidoses.
Emily N Barker, Mehrafarin Ashiri, Jennifer T Saville, Richard Hemming, Nikolas Furletti, Brian L Mark

Biol Open· September 2025

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Inhibiting Infectious Bronchitis Virus PLpro Using Ubiquitin Variants.
Vera J E van Vliet, Olivia Roscow, Kihun Kim, Brian L Mark, Marjolein Kikkert

Int J Mol Sci· May 2025

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Suppressing Tymovirus replication in plants using a variant of ubiquitin.
Anuradha De Silva, Kihun Kim, John Weiland, Jihyun Hwang, Jacky Chung, Brian L Mark

PLoS Pathog· January 2025

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Viral deubiquitinating proteases and the promising strategies of their inhibition.
Vera J E van Vliet, Anuradha De Silva, Brian L Mark, Marjolein Kikkert

Virus Res· June 2024

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Deubiquitinating activity of SARS-CoV-2 papain-like protease does not influence virus replication or innate immune responses in vivo.
Mariska van Huizen, Jonna R Bloeme-Ter Horst, Heidi L M de Gruyter, Paul P Geurink, Gerbrand J van der Heden van Noort, Brian L Mark

PLoS Pathog· March 2024

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Demonstrating the importance of porcine reproductive and respiratory syndrome virus papain-like protease 2 deubiquitinating activity in viral replication by structure-guided mutagenesis.
Ben A Bailey-Elkin, Robert C M Knaap, Anuradha De Silva, Ilse M Boekhoud, Sandra Mous, Brian L Mark

PLoS Pathog· December 2023

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Biochemical Insights into Imipenem Collateral Susceptibility Driven by Mutations Conferring Ceftolozane/Tazobactam Resistance in Pseudomonas aeruginosa.
Gabriel Cabot, Kihun Kim, Brian L Mark, Antonio Oliver, Mazdak Khajehpour

Antimicrob Agents Chemother· February 2023

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Ubiquitin variants potently inhibit SARS-CoV-2 PLpro and viral replication via a novel site distal to the protease active site.
Vera J E van Vliet, Nhan Huynh, Judith Palà, Ankoor Patel, Alex Singer, Brian L Mark

PLoS Pathog· December 2022

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Increased phosphorylation of HexM improves lysosomal uptake and potential for managing GM2 gangliosidoses.
Graeme Benzie, Kristen Bouma, Taylor Battellino, Steven Cooper, Rick Hemming, Brian L Mark

BBA Adv· December 2021

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The endopeptidase of the maize-affecting Marafivirus type member maize rayado fino virus doubles as a deubiquitinase.
Ankoor Patel, Jessica A M McBride, Brian L Mark

J Biol Chem· August 2021

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Frontrunners in the race to develop a SARS-CoV-2 vaccine.
Raquel L Russell, Peter Pelka, Brian L Mark

Can J Microbiol· March 2021

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Characterization of the sorbitol dehydrogenase SmoS from Sinorhizobium meliloti 1021.
MacLean G Kohlmeier, Ben A Bailey-Elkin, Brian L Mark, Ivan J Oresnik

Acta Crystallogr D Struct Biol· March 2021

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Letter to the Editor.
Brian L Mark, Don Mahuran

Mol Ther· January 2021

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Molecular characterization of the RNA-protein complex directing -2/-1 programmed ribosomal frameshifting during arterivirus replicase expression.
Ankoor Patel, Emmely E Treffers, Markus Meier, Trushar R Patel, Jörg Stetefeld, Brian L Mark

J Biol Chem· December 2020

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Determining the Electronic Structure of Paramagnetic Intermediates in membrane proteins: A high-resolution 2D H hyperfine sublevel correlation study of the redox-active tyrosines of photosystem II.
Brian Mark, Christopher S Coates, Sawako Sugimura, Amgalanbaatar Baldansuren, Ji Ku

Biochim Biophys Acta Biomembr· November 2020

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Adding Insult to Injury: Mechanistic Basis for How AmpC Mutations Allow Pseudomonas aeruginosa To Accelerate Cephalosporin Hydrolysis and Evade Avibactam.
Cole L Slater, Judith Winogrodzki, Pablo A Fraile-Ribot, Antonio Oliver, Mazdak Khajehpour, Brian L Mark

Antimicrob Agents Chemother· August 2020

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HYSCORE and DFT Studies of Proton-Coupled Electron Transfer in a Bioinspired Artificial Photosynthetic Reaction Center.
Dalvin D Méndez-Hernández, Amgalanbaatar Baldansuren, Vidmantas Kalendra, Philip Charles, Brian Mark

iScience· August 2020

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Independent inhibition of the polymerase and deubiquitinase activities of the Crimean-Congo Hemorrhagic Fever Virus full-length L-protein.
Egor P Tchesnokov, Ben A Bailey-Elkin, Brian L Mark, Matthias Götte

PLoS Negl Trop Dis· June 2020

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Molecular Basis for the Potent Inhibition of the Emerging Carbapenemase VCC-1 by Avibactam.
Chand S Mangat, Grishma Vadlamani, Viktor Holicek, Mitchell Chu, Veronica L C Larmour, Brian L Mark

Antimicrob Agents Chemother· April 2019

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A mechanism-based GlcNAc-inspired cyclophellitol inactivator of the peptidoglycan recycling enzyme NagZ reverses resistance to β-lactams in Pseudomonas aeruginosa.
Louisa A Ho, Judith L Winogrodzki, Aleksandra W Debowski, Zarina Madden, David J Vocadlo, Brian L Mark

Chem Commun (Camb)· September 2018

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Structural and mechanistic analysis of a β-glycoside phosphorylase identified by screening a metagenomic library.
Spencer S Macdonald, Ankoor Patel, Veronica L C Larmour, Connor Morgan-Lang, Steven J Hallam, Brian L Mark

J Biol Chem· March 2018

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Structure and Function of Viral Deubiquitinating Enzymes.
Ben A Bailey-Elkin, Robert C M Knaap, Marjolein Kikkert, Brian L Mark

J Mol Biol· November 2017

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Conformational flexibility of the glycosidase NagZ allows it to bind structurally diverse inhibitors to suppress β-lactam antibiotic resistance.
Grishma Vadlamani, Keith A Stubbs, Jérôme Désiré, Yves Blériot, David J Vocadlo, Brian L Mark

Protein Sci· June 2017

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Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants.
Wei Zhang, Ben A Bailey-Elkin, Robert C M Knaap, Baldeep Khare, Tim J Dalebout, Brian L Mark

PLoS Pathog· May 2017

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Mutations in HYAL2, Encoding Hyaluronidase 2, Cause a Syndrome of Orofacial Clefting and Cor Triatriatum Sinister in Humans and Mice.
Martina M A Muggenthaler, Biswajit Chowdhury, S Naimul Hasan, Harold E Cross, Brian Mark

PLoS Genet· January 2017

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