Publications by authors named "Brian R Leaker"

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Effects of the Toll-like receptor 7 (TLR7) agonist, AZD8848, on allergen-induced responses in patients with mild asthma: a double-blind, randomised, parallel-group study.
Brian R Leaker, Dave Singh, Sam Lindgren, Gun Almqvist, Leif Eriksson

Respir Res· December 2019

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Evaluation of systemic absorption and bronchodilator effect of glycopyrronium bromide delivered by nebulizer or a dry powder inhaler in subjects with chronic obstructive pulmonary disease.
Brian R Leaker, Dave Singh, Grant C Nicholson, Blanka Hezelova, Thomas Goodin

Respir Res· June 2019

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The effects of the selective muscarinic M3 receptor antagonist darifenacin, and of hyoscine (scopolamine), on motion sickness, skin conductance & cognitive function.
John F Golding, Keith A Wesnes, Brian R Leaker

Br J Clin Pharmacol· July 2018

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Using magnetic resonance imaging to quantify the inflammatory response following allergen challenge in allergic rhinitis.
Brian R Leaker, Glenis Scadding, C Richard Jones, Peter J Barnes

Immun Inflamm Dis· December 2015

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The novel inhaled glucocorticoid receptor agonist GW870086X protects against adenosine-induced bronchoconstriction in asthma.
Brian R Leaker, Brian O'Connor, Dave Singh, Peter J Barnes

J Allergy Clin Immunol· August 2015

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Efficacy and safety of nebulized glycopyrrolate for administration using a high efficiency nebulizer in patients with chronic obstructive pulmonary disease.
Brian R Leaker, Peter J Barnes, C Richard Jones, Ahmet Tutuncu, Dave Singh

Br J Clin Pharmacol· March 2015

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The effect of the novel phosphodiesterase-4 inhibitor MEM 1414 on the allergen induced responses in mild asthma.
Brian R Leaker, Dave Singh, Ferhana Y Ali, Peter J Barnes, Brian O'Connor

BMC Pulm Med· October 2014

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Inhibition of LPS-induced airway neutrophilic inflammation in healthy volunteers with an oral CXCR2 antagonist.
Brian R Leaker, Peter J Barnes, Brian O'Connor

Respir Res· December 2013

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Safety of regadenoson, an adenosine A2A receptor agonist for myocardial perfusion imaging, in mild asthma and moderate asthma patients: a randomized, double-blind, placebo-controlled trial.
Brian R Leaker, B O'Connor, Trevor T Hansel, Peter J Barnes, Lixen Meng

J Nucl Cardiol· July 2008

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Optimized dialysis and protease inhibition of sputum dithiothreitol supernatants.
Edward M Erin, Gavin R Jenkins, Onn Min Kon, Angela S Zacharasiewicz, Grant C Nicholson, Brian R Leaker

Am J Respir Crit Care Med· January 2008

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The effects of a monoclonal antibody directed against tumor necrosis factor-alpha in asthma.
Edward M Erin, Brian R Leaker, Grant C Nicholson, Andrew J Tan, Linda M Green

Am J Respir Crit Care Med· October 2006

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