Publications by authors named "Brian Raymer"

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Small molecule inhibitors of PCSK9. SAR investigations of head and amine groups.
Gary E Aspnes, Steven B Coffey, Etzer Darout, Anne-Marie Dechert-Schmitt, Robert G Dullea, Brian Raymer

Bioorg Med Chem Lett· August 2023

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Discovery of the Potent and Selective MC4R Antagonist PF-07258669 for the Potential Treatment of Appetite Loss.
Michelle R Garnsey, Aaron C Smith, Jana Polivkova, Autumn L Arons, Guoyun Bai, Brian Raymer

J Med Chem· March 2023

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Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose.
Kentaro Futatsugi, Aaron C Smith, Meihua Tu, Brian Raymer, Kay Ahn

J Med Chem· November 2020

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Sleep modulating agents.
Younggi Choi, Brian K Raymer

Bioorg Med Chem Lett· August 2019

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Lead-like Drugs: A Perspective.
Brian Raymer, Samit K Bhattacharya

J Med Chem· December 2018

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Discovery of N-(piperidin-3-yl)-N-(pyridin-2-yl)piperidine/piperazine-1-carboxamides as small molecule inhibitors of PCSK9.
Allyn T Londregan, Gary Aspnes, Chris Limberakis, Paula M Loria, Kim F McClure, Brian Raymer

Bioorg Med Chem Lett· December 2018

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Liver-Targeted Small-Molecule Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9 Synthesis.
Kim F McClure, David W Piotrowski, Donna Petersen, Liuqing Wei, Jun Xiao, Brian Raymer

Angew Chem Int Ed Engl· December 2017

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Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK).
Kim Huard, Kay Ahn, Paul Amor, David A Beebe, Kris A Borzilleri, Brian Raymer

J Med Chem· September 2017

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Small molecule and peptide therapies for chronic heart failure: a patent review (2011 - 2014).
Brian Raymer, David Ebner

Expert Opin Ther Pat· May 2016

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Synthesis and characterization of a BODIPY-labeled derivative of Soraphen A that binds to acetyl-CoA carboxylase.
Brian Raymer, Michael Kavana, Allen Price, Bing Wang, Lisa Corcoran

Bioorg Med Chem Lett· May 2009

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Total synthesis of (+)-azaspiracid-1. An exhibition of the intricacies of complex molecule synthesis.
David A Evans, Lisbet Kvaernø, Travis B Dunn, André Beauchemin, Brian Raymer

J Am Chem Soc· December 2008

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Total synthesis of (+)-azaspiracid-1. Part I: Synthesis of the fully elaborated ABCD aldehyde.
David A Evans, Lisbet Kvaernø, Jason A Mulder, Brian Raymer, Travis B Dunn

Angew Chem Int Ed Engl· October 2007

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Total synthesis of (+)-azaspiracid-1. Part II: synthesis of the EFGHI sulfone and completion of the synthesis.
David A Evans, Travis B Dunn, Lisbet Kvaernø, André Beauchemin, Brian Raymer

Angew Chem Int Ed Engl· October 2007

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