Publications by authors named "Brian Wayland"

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INCB050465 (Parsaclisib), a Novel Next-Generation Inhibitor of Phosphoinositide 3-Kinase Delta (PI3Kδ).
Eddy W Yue, Yun-Long Li, Brent Douty, Chunhong He, Song Mei, Brian Wayland

ACS Med Chem Lett· November 2019

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INCB24360 (Epacadostat), a Highly Potent and Selective Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitor for Immuno-oncology.
Eddy W Yue, Richard Sparks, Padmaja Polam, Dilip Modi, Brent Douty, Brian Wayland

ACS Med Chem Lett· May 2017

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Discovery of potent competitive inhibitors of indoleamine 2,3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model.
Eddy W Yue, Brent Douty, Brian Wayland, Michael Bower, Xiangdong Liu

J Med Chem· December 2009

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Isothiazolidinone inhibitors of PTP1B containing imidazoles and imidazolines.
Brent Douty, Brian Wayland, Paul J Ala, Michael J Bower, James Pruitt

Bioorg Med Chem Lett· January 2008

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Structural insights into the design of nonpeptidic isothiazolidinone-containing inhibitors of protein-tyrosine phosphatase 1B.
Paul J Ala, Lucie Gonneville, Milton Hillman, Mary Becker-Pasha, Eddy W Yue, Brian Wayland

J Biol Chem· December 2006

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Structural basis for inhibition of protein-tyrosine phosphatase 1B by isothiazolidinone heterocyclic phosphonate mimetics.
Paul J Ala, Lucie Gonneville, Milton C Hillman, Mary Becker-Pasha, Min Wei, Brian Wayland

J Biol Chem· October 2006

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Isothiazolidinone heterocycles as inhibitors of protein tyrosine phosphatases: synthesis and structure-activity relationships of a peptide scaffold.
Eddy W Yue, Brian Wayland, Brent Douty, Matthew L Crawley, Eric McLaughlin

Bioorg Med Chem· September 2006

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Structure-based design and discovery of protein tyrosine phosphatase inhibitors incorporating novel isothiazolidinone heterocyclic phosphotyrosine mimetics.
Andrew P Combs, Eddy W Yue, Michael Bower, Paul J Ala, Brian Wayland

J Med Chem· October 2005

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