Publications by authors named "Brian Wiens"

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Efficacy and safety of izokibep in patients with active psoriatic arthritis: a randomised, double-blind, placebo-controlled, phase 2 study.
Peter C Taylor, Philip J Mease, Kurt de Vlam, Shephard Mpofu, Dieter Wetzel, Brian Wiens

Ann Rheum Dis· April 2025

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The Impact of Major Events on Ongoing Noninferiority Trials, With Application to COVID-19.
Brian L Wiens, Ilya Lipkovich

Stat Biopharm Res· August 2020

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Multiple comparisons in non-inferiority trials: Reaction to recent regulatory guidance on multiple endpoints in clinical trials.
Brian L Wiens

J Biopharm Stat· July 2019

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A randomized, placebo-controlled trial of cenicriviroc for treatment of nonalcoholic steatohepatitis with fibrosis.
Scott L Friedman, Vlad Ratziu, Stephen A Harrison, Manal F Abdelmalek, Guruprasad P Aithal, Brian L Wiens

Hepatology· May 2018

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Andexanet Alfa for Acute Major Bleeding Associated with Factor Xa Inhibitors.
Stuart J Connolly, Truman J Milling, John W Eikelboom, C Michael Gibson, John T Curnutte, Brian L Wiens

N Engl J Med· September 2016

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Extended Thromboprophylaxis with Betrixaban in Acutely Ill Medical Patients.
Alexander T Cohen, Robert A Harrington, Samuel Z Goldhaber, Russell D Hull, Brian L Wiens

N Engl J Med· August 2016

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Selection of hypothesis weights and ordering when testing multiple hypotheses in clinical trials.
Brian L Wiens, Alex Dmitrienko, Olga Marchenko

J Biopharm Stat· June 2014

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Recent Statistical Contributions to Medical Device Development.
Brian L Wiens, Theodore C Lystig, Scott M Berry

Ther Innov Regul Sci· January 2014

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Multiple testing procedures in two pivotal clinical trials for approval of a new pharmaceutical product.
Brian L Wiens

J Biopharm Stat· July 2011

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Effects of low-dose oral enoximone administration on mortality, morbidity, and exercise capacity in patients with advanced heart failure: the randomized, double-blind, placebo-controlled, parallel group ESSENTIAL trials.
Marco Metra, Eric Eichhorn, William T Abraham, Jennifer Linseman, Michael Böhm, Brian Wiens

Eur Heart J· December 2009

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Ambient air total gaseous mercury concentrations in the vicinity of coal-fired power plants in Alberta, Canada.
Maxwell Mazur, Rachel Mintz, Monique Lapalme, Brian Wiens

Sci Total Environ· December 2009

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A selective endothelin-receptor antagonist to reduce blood pressure in patients with treatment-resistant hypertension: a randomised, double-blind, placebo-controlled trial.
Michael A Weber, Henry Black, George Bakris, Henry Krum, Stuart Linas, Brian L Wiens

Lancet· October 2009

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General multistage gatekeeping procedures.
Alex Dmitrienko, Ajit C Tamhane, Brian L Wiens

Biom J· October 2008

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A note on tree gatekeeping procedures in clinical trials.
Alex Dmitrienko, Ajit C Tamhane, Lingyun Liu, Brian L Wiens

Stat Med· July 2008

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Ambrisentan for the treatment of pulmonary arterial hypertension: results of the ambrisentan in pulmonary arterial hypertension, randomized, double-blind, placebo-controlled, multicenter, efficacy (ARIES) study 1 and 2.
Nazzareno Galiè, Horst Olschewski, Ronald J Oudiz, Fernando Torres, Adaani Frost, Brian L Wiens

Circulation· June 2008

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The role of intention to treat in analysis of noninferiority studies.
Brian L Wiens, William Zhao

Clin Trials· December 2007

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Efficacy and safety of darusentan in patients with resistant hypertension: results from a randomized, double-blind, placebo-controlled dose-ranging study.
Henry R Black, George L Bakris, Michael A Weber, Robert Weiss, Mahfouz El Shahawy, Brian L Wiens

J Clin Hypertens (Greenwich)· October 2007

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Tree-structured gatekeeping tests in clinical trials with hierarchically ordered multiple objectives.
Alex Dmitrienko, Brian L Wiens, Ajit C Tamhane, Xin Wang

Stat Med· May 2007

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Randomization as a basis for inference in noninferiority trials.
Brian L Wiens

Pharm Stat· February 2007

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Fallback tests in dose-response clinical trials.
Alex Dmitrienko, Brian Wiens, Peter Westfall

J Biopharm Stat· December 2006

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The fallback procedure for evaluating a single family of hypotheses.
Brian L Wiens, Alexei Dmitrienko

J Biopharm Stat· December 2005

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First and subsequent cycle use of pegfilgrastim prevents febrile neutropenia in patients with breast cancer: a multicenter, double-blind, placebo-controlled phase III study.
Charles L Vogel, Marek Z Wojtukiewicz, Robert R Carroll, Sergei A Tjulandin, Luis Javier Barajas-Figueroa, Brian L Wiens

J Clin Oncol· February 2005

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Assessing the impact of endpoint shopping on power in confirmatory clinical trials.
Brian L Wiens

J Biopharm Stat· May 2003

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Testing for interaction in studies of noninferiority.
Brian L Wiens, Joseph F Heyse

J Biopharm Stat· February 2003

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