Publications by authors named "Brittany D Spitznagel"

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Further Structure-Activity Relationship of G Protein-Gated Inwardly Rectifying Potassium Channels 1/2 Activators: Synthesis and Biological Characterization of In Vitro Tool Compounds.
Sumaiya Nahid, Fahad Imtiaz Rahman, Yu Du, Brittany D Spitznagel, Sandeep K Singh

ChemMedChem· July 2025

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Structure-Activity Relationship Studies in a Series of 2-Aryloxy--(pyrimidin-5-yl)acetamide Inhibitors of SLACK Potassium Channels.
Nigam M Mishra, Brittany D Spitznagel, Yu Du, Yasmeen K Mohamed, Ying Qin

Molecules· November 2024

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Heterozygous expression of a gain-of-function variant has differential effects on somatostatin- and parvalbumin-expressing cortical GABAergic neurons.
Amy N Shore, Keyong Li, Mona Safari, Alshaima'a M Qunies, Brittany D Spitznagel

Elife· October 2024

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Heterozygous expression of a gain-of-function variant has differential effects on SST- and PV-expressing cortical GABAergic neurons.
Amy N Shore, Keyong Li, Mona Safari, Alshaima'a M Qunies, Brittany D Spitznagel

bioRxiv· August 2024

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Structure-Activity Relationship Studies in a Series of Xanthine Inhibitors of SLACK Potassium Channels.
Alshaima'a M Qunies, Brittany D Spitznagel, Yu Du, Paul K Peprah, Yasmeen K Mohamed

Molecules· May 2024

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Design, synthesis, and biological evaluation of a novel series of 1,2,4-oxadiazole inhibitors of SLACK potassium channels: Identification of in vitro tool VU0935685.
Alshaima'a M Qunies, Brittany D Spitznagel, Yu Du, C David Weaver, Kyle A Emmitte

Bioorg Med Chem· November 2023

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Acute manganese exposure impairs glutamatergic function in a young mouse model of Alzheimer's disease.
Brittany D Spitznagel, Rebecca A Buchanan, David C Consoli, Megan K Thibert, Aaron B Bowman

Neurotoxicology· March 2023

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Altered EEG, disrupted hippocampal long-term potentiation and neurobehavioral deficits implicate a delirium-like state in a mouse model of sepsis.
David C Consoli, Brittany D Spitznagel, Benjamin M Owen, Hakmook Kang, Shawniqua Williams Roberson

Brain Behav Immun· January 2023

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A selective inhibitor of the sperm-specific potassium channel SLO3 impairs human sperm function.
Maximilian Lyon, Ping Li, Juan J Ferreira, Roman M Lazarenko, Sujay V Kharade, Brittany D Spitznagel

Proc Natl Acad Sci U S A· January 2023

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Structure-activity relationship studies in a new series of 2-amino-N-phenylacetamide inhibitors of Slack potassium channels.
Alshaima'a M Qunies, Nigam M Mishra, Brittany D Spitznagel, Yu Du, Valerie S Acuña

Bioorg Med Chem Lett· November 2022

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Discovery of Small Molecule KCC2 Potentiators Which Attenuate Seizure-Like Activity in Cultured Neurons.
Francis J Prael Iii, Kwangho Kim, Yu Du, Brittany D Spitznagel, Gary A Sulikowski

Front Cell Dev Biol· June 2022

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Manganese-induced hyperactivity and dopaminergic dysfunction depend on age, sex and YAC128 genotype.
Jordyn M Wilcox, David C Consoli, Krista C Paffenroth, Brittany D Spitznagel, Erin S Calipari

Pharmacol Biochem Behav· February 2022

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VU0606170, a Selective Slack Channels Inhibitor, Decreases Calcium Oscillations in Cultured Cortical Neurons.
Brittany D Spitznagel, Nigam M Mishra, Alshaima'a M Qunies, Francis J Prael, Yu Du

ACS Chem Neurosci· November 2020

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Discovery and Characterization of VU0529331, a Synthetic Small-Molecule Activator of Homomeric G Protein-Gated, Inwardly Rectifying, Potassium (GIRK) Channels.
Krystian A Kozek, Yu Du, Swagat Sharma, Francis J Prael, Brittany D Spitznagel

ACS Chem Neurosci· January 2019

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