Publications by authors named "Bruce A Kerwin"

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Roadmap for Drug Product Development and Manufacturing of Biologics.
Krishnan Sampathkumar, Bruce A Kerwin

J Pharm Sci· February 2024

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The Development of a Novel Aflibercept Formulation for Ocular Delivery.
J Alaina Floyd, Alison J Gillespie, Nancy S Nightlinger, Christine Siska, Bruce A Kerwin

J Pharm Sci· February 2024

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Framework Mutations of the 10-1074 bnAb Increase Conformational Stability, Manufacturability, and Stability While Preserving Full Neutralization Activity.
Bruce A Kerwin, Chelsey Bennett, Yan Brodsky, Rutilio Clark, J Alaina Floyd

J Pharm Sci· January 2020

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Evaluation of Crystal Zenith Microtiter Plates for High-Throughput Formulation Screening.
J Alaina Floyd, Jeremy M Shaver, Alison J Gillespie, Unjy Park, Richard S Rogers, Bruce A Kerwin

J Pharm Sci· January 2020

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Shocking Data on Parcel Shipments of Protein Solutions.
Christine Siska, Paul Harber, Bruce A Kerwin

J Pharm Sci· January 2020

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Coformulation of Broadly Neutralizing Antibodies 3BNC117 and PGT121: Analytical Challenges During Preformulation Characterization and Storage Stability Studies.
Ashaben Patel, Vineet Gupta, John Hickey, Nancy S Nightlinger, Richard S Rogers, Bruce A Kerwin

J Pharm Sci· December 2018

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Adapting the chemical unfolding assay for high-throughput protein screening using experimental and spectroscopic corrections.
J Alaina Floyd, Christine Siska, Rutilio H Clark, Bruce A Kerwin, Jeremy M Shaver

Anal Biochem· December 2018

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Reply to "Comment on 'Osmolyte Effects on Monoclonal Antibody Stability and Concentration-Dependent Protein Interactions with Water and Common Osmolytes'".
Gregory V Barnett, Vladimir I Razinkov, Bruce A Kerwin, Steven Blake, Wei Qi

J Phys Chem B· November 2016

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Osmolyte Effects on Monoclonal Antibody Stability and Concentration-Dependent Protein Interactions with Water and Common Osmolytes.
Gregory V Barnett, Vladimir I Razinkov, Bruce A Kerwin, Steven Blake, Wei Qi

J Phys Chem B· April 2016

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Acetate- and Citrate-Specific Ion Effects on Unfolding and Temperature-Dependent Aggregation Rates of Anti-Streptavidin IgG1.
Gregory V Barnett, Vladimir I Razinkov, Bruce A Kerwin, Alexander Hillsley, Christopher J Roberts

J Pharm Sci· March 2016

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Structural Changes and Aggregation Mechanisms for Anti-Streptavidin IgG1 at Elevated Concentration.
Gregory V Barnett, Wei Qi, Samiul Amin, E Neil Lewis, Vladimir I Razinkov, Bruce A Kerwin

J Phys Chem B· December 2015

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Specific-ion effects on the aggregation mechanisms and protein-protein interactions for anti-streptavidin immunoglobulin gamma-1.
Gregory V Barnett, Vladimir I Razinkov, Bruce A Kerwin, Thomas M Laue, Andrea H Woodka

J Phys Chem B· May 2015

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Characterization of an oncolytic herpes simplex virus drug candidate.
Ozan S Kumru, Sangeeta B Joshi, Prem Thapa, Nigel Pheasey, Paul S Bullock, Bruce A Kerwin

J Pharm Sci· February 2015

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Quantitative evaluation of colloidal stability of antibody solutions using PEG-induced liquid-liquid phase separation.
Ying Wang, Ramil F Latypov, Aleksey Lomakin, Julie A Meyer, Bruce A Kerwin

Mol Pharm· May 2014

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Entanglement model of antibody viscosity.
Jeremy D Schmit, Feng He, Shradha Mishra, Randal R Ketchem, Christopher E Woods, Bruce A Kerwin

J Phys Chem B· May 2014

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Linking the solution viscosity of an IgG2 monoclonal antibody to its structure as a function of pH and temperature.
Weiqiang Cheng, Sangeeta B Joshi, Nishant Kumar Jain, Feng He, Bruce A Kerwin

J Pharm Sci· December 2013

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Understanding the relevance of local conformational stability and dynamics to the aggregation propensity of an IgG1 and IgG2 monoclonal antibodies.
Santosh V Thakkar, Neha Sahni, Sangeeta B Joshi, Bruce A Kerwin, Feng He

Protein Sci· October 2013

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Development of a human antibody tolerant mouse model to assess the immunogenicity risk due to aggregated biotherapeutics.
Vivian Bi, Vibha Jawa, Marisa K Joubert, Arunan Kaliyaperumal, Catherine Eakin, Bruce A Kerwin

J Pharm Sci· October 2013

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The photolysis of disulfide bonds in IgG1 and IgG2 leads to selective intramolecular hydrogen transfer reactions of cysteine Thiyl radicals, probed by covalent H/D exchange and RPLC-MS/MS analysis.
Shuxia Zhou, Olivier Mozziconacci, Bruce A Kerwin, Christian Schöneich

Pharm Res· May 2013

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Fluorogenic tagging methodology applied to characterize oxidized tyrosine and phenylalanine in an immunoglobulin monoclonal antibody.
Shuxia Zhou, Olivier Mozziconacci, Bruce A Kerwin, Christian Schöneich

Pharm Res· May 2013

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Light-induced conversion of Trp to Gly and Gly hydroperoxide in IgG1.
Jessica Haywood, Olivier Mozziconacci, Kevin M Allegre, Bruce A Kerwin, Christian Schöneich

Mol Pharm· March 2013

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Highly aggregated antibody therapeutics can enhance the in vitro innate and late-stage T-cell immune responses.
Marisa K Joubert, Martha Hokom, Catherine Eakin, Lei Zhou, Meghana Deshpande, Bruce A Kerwin

J Biol Chem· July 2012

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Comparison of high-throughput biophysical methods to identify stabilizing excipients for a model IgG2 monoclonal antibody: conformational stability and kinetic aggregation measurements.
Weiqiang Cheng, Sangeeta B Joshi, Feng He, David N Brems, Bing He, Bruce A Kerwin

J Pharm Sci· May 2012

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Effect of pH and light on aggregation and conformation of an IgG1 mAb.
Bruce D Mason, Christian Schöneich, Bruce A Kerwin

Mol Pharm· April 2012

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Reversible hydrogen transfer reactions of cysteine thiyl radicals in peptides: the conversion of cysteine into dehydroalanine and alanine, and of alanine into dehydroalanine.
Olivier Mozziconacci, Bruce A Kerwin, Christian Schöneich

J Phys Chem B· October 2011

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