Publications by authors named "Bruce Holbein"

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Iron Metabolism in the Recovery Phase of Critical Illness with a Focus on Sepsis.
Xiyang Zhang, Bruce Holbein, Juan Zhou, Christian Lehmann

Int J Mol Sci· June 2024

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The Hydroxypyridinone Iron Chelator DIBI Reduces Bacterial Load and Inflammation in Experimental Lung Infection.
Xiyang Zhang, Rhea Nickerson, Lauren Burton, Ashley Stueck, Bruce Holbein

Biomedicines· June 2024

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Anti-inflammatory iron chelator, DIBI, reduces leukocyte-endothelial adhesion and clinical symptoms of LPS-induced interstitial cystitis in mice.
Georg Hagn, Bruce Holbein, Juan Zhou, Christian Lehmann

Clin Hemorheol Microcirc· October 2023

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Iron Chelation as a Potential Therapeutic Approach in Acute Lung Injury.
Xiyang Zhang, Juan Zhou, Bruce E Holbein, Christian Lehmann

Life (Basel)· July 2023

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Dysregulated Iron Homeostasis as Common Disease Etiology and Promising Therapeutic Target.
Bruce E Holbein, Christian Lehmann

Antioxidants (Basel)· March 2023

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Iron Withdrawal with DIBI, a Novel 3-Hydroxypyridin-4-One Chelator Iron-Binding Polymer, Attenuates Macrophage Inflammatory Responses.
Javad Ghassemi-Rad, Wasundara Fernando, Bruce E Holbein, David W Hoskin

Adv Pharm Bull· March 2023

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Iron Chelator DIBI Suppresses Formation of Ciprofloxacin-Induced Antibiotic Resistance in .
David S Allan, Bruce E Holbein

Antibiotics (Basel)· November 2022

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Antimicrobial Activity of the Iron-Chelator, DIBI, against Multidrug-Resistant Canine Methicillin-Susceptible : A Preliminary Study of Four Clinical Strains.
Francesca Paola Nocera, Giuseppe Iovane, Luisa De Martino, Bruce E Holbein

Pathogens· June 2022

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Anti-Inflammatory Effects of the Iron Chelator, DIBI, in Experimental Acute Lung Injury.
Christian Lehmann, Nazli Alizadeh-Tabrizi, Stefan Hall, Sufyan Faridi, Irene Euodia, Bruce Holbein

Molecules· June 2022

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Iron-withdrawing anti-infectives for new host-directed therapies based on iron dependence, the Achilles' heel of antibiotic-resistant microbes.
Bruce E Holbein, M Trisha C Ang, David S Allan, Wangxue Chen, Christian Lehmann

Environ Chem Lett· April 2021

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Comparison of Treatment Effects of Different Iron Chelators in Experimental Models of Sepsis.
Christian Lehmann, Maral Aali, Juan Zhou, Bruce Holbein

Life (Basel)· January 2021

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The novel iron chelator, DIBI, attenuates inflammation and improves outcome in colon ascendens stent peritonitis-induced experimental sepsis.
Danielle Fokam, Maral Aali, Kayle Dickson, Cassidy Scott, Bruce Holbein

Clin Hemorheol Microcirc· December 2020

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Enhanced Fe binding through cooperativity of 3-hydroxypyridin-4-one groups within a linear co-polymer: wrapping effect leading to superior antimicrobial activity.
Roger Gumbau-Brisa, M Trisha C Ang, Bruce E Holbein, Matthias Bierenstiel

Biometals· December 2020

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Iron Chelation in Murine Models of Systemic Inflammation Induced by Gram-Positive and Gram-Negative Toxins.
Danielle Fokam, Kayle Dickson, Kiyana Kamali, Bruce Holbein, Patricia Colp

Antibiotics (Basel)· May 2020

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Iron Sequestrant DIBI, a Potential Alternative for Nares Decolonization of Methicillin-Resistant Staphylococcus aureus, Is Anti-infective and Inhibitory for Mupirocin-Resistant Isolates.
David S Allan, Maria Del Carmen Parquet, Kimberley A Savage, Bruce E Holbein

Antimicrob Agents Chemother· February 2020

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Iron should be restricted in acute infection.
Cassidy R Scott, Bruce E Holbein, Christian D Lehmann

Front Biosci (Landmark Ed)· January 2020

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DIBI, a novel 3-hydroxypyridin-4-one chelator iron-binding polymer, inhibits breast cancer cell growth and functions as a chemosensitizer by promoting S-phase DNA damage.
Anna L Greenshields, Melanie R Power Coombs, Wasundara Fernando, Bruce E Holbein, David W Hoskin

Biometals· December 2019

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Potential Mechanisms of Mucin-Enhanced Acinetobacter baumannii Virulence in the Mouse Model of Intraperitoneal Infection.
Greg Harris, Bruce E Holbein, Hongyan Zhou, H Howard Xu, Wangxue Chen

Infect Immun· November 2019

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Antibiotic-Resistant Is Susceptible to the Novel Iron-Sequestering Anti-infective DIBI and in Experimental Pneumonia in Mice.
Maria Del Carmen Parquet, Kimberley A Savage, David S Allan, M Trisha C Ang, Wangxue Chen, Bruce E Holbein

Antimicrob Agents Chemother· September 2019

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Iron Chelation as Novel Treatment for Interstitial Cystitis.
Georg Hagn, Robert Westhofen, Ian Burkovskiy, Bruce Holbein, Juan Zhou

Pharmacology· March 2019

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Erratum for Savage et al., "Iron Restriction to Clinical Isolates of Candida albicans by the Novel Chelator DIBI Inhibits Growth and Increases Sensitivity to Azoles and in a Murine Model of Experimental Vaginitis".
Kimberley A Savage, Maria Del Carmen Parquet, David S Allan, Ross J Davidson, Bruce E Holbein

Antimicrob Agents Chemother· February 2019

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Selective sensitivity of the gut microbiome to iron chelators in polybacterial abdominal sepsis.
Kayle Dickson, Simo Liu, Juan Zhou, Morgan Langille, Bruce E Holbein

Med Hypotheses· November 2018

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Iron Restriction to Clinical Isolates of Candida albicans by the Novel Chelator DIBI Inhibits Growth and Increases Sensitivity to Azoles and in a Murine Model of Experimental Vaginitis.
Kimberley A Savage, Maria del Carmen Parquet, David S Allan, Ross J Davidson, Bruce E Holbein

Antimicrob Agents Chemother· August 2018

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Novel Iron-Chelator DIBI Inhibits Growth, Suppresses Experimental MRSA Infection in Mice and Enhances the Activities of Diverse Antibiotics .
Maria Del Carmen Parquet, Kimberley A Savage, David S Allan, Ross J Davidson, Bruce E Holbein

Front Microbiol· August 2018

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DIBI, a 3-hydroxypyridin-4-one chelator iron-binding polymer with enhanced antimicrobial activity.
M Trisha C Ang, Roger Gumbau-Brisa, David S Allan, Robert McDonald, Michael J Ferguson, Bruce E Holbein

Medchemcomm· July 2018

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