Publications by authors named "Bruce S Ross"

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A Chemical Approach to Introduce 2,6-Diaminopurine and 2-Aminoadenine Conjugates into Oligonucleotides without Need for Protecting Groups.
Mimouna Madaoui, Dhrubajyoti Datta, Kelly Wassarman, Ivan Zlatev, Martin Egli, Bruce S Ross

Org Lett· August 2022

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Correction to Nucleoside, Nucleotide, and Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B RNA-Dependent RNA-Polymerase.
Michael J Sofia, Wonsuk Chang, Phillip A Furman, Ralph T Mosley, Bruce S Ross

J Med Chem· April 2017

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β-D-2'-α-F-2'-β-C-Methyl-6-O-substituted 3',5'-cyclic phosphate nucleotide prodrugs as inhibitors of hepatitis C virus replication: a structure-activity relationship study.
Jinfa Du, Donghui Bao, Byoung-Kwon Chun, Ying Jiang, P Ganapati Reddy, Bruce S Ross

Bioorg Med Chem Lett· September 2012

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Rapid differentiation of nucleotide phosphoramidate diastereomers by electrospray ionization tandem mass spectrometry.
Donghui Bao, P Ganapati Reddy, Bruce S Ross, Michael J Sofia

Rapid Commun Mass Spectrom· August 2012

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A liquid chromatography-tandem mass spectrometry method for the quantitative determination of diastereomers of a phosphoramidate nucleotide prodrug (PSI-7851) in human plasma.
Donghui Bao, Bruce S Ross, Michael J Sofia

Biomed Chromatogr· May 2012

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Phosphoramidate prodrugs of (-)-β-D-(2R,4R)-dioxolane-thymine (DOT) as potent anti-HIV agents.
Peiyuan Wang, Suguna Rachakonda, Veronique Zennou, Meg Keilman, Congrong Niu, Bruce S Ross

Antivir Chem Chemother· May 2012

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Nucleoside, nucleotide, and non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA-polymerase.
Michael J Sofia, Wonsuk Chang, Phillip A Furman, Ralph T Mosley, Bruce S Ross

J Med Chem· March 2012

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Synthesis of stable isotope labeled analogs of the anti-hepatitis C virus nucleotide prodrugs PSI-7977 and PSI-352938.
Byoung-Kwon Chun, Jinfa Du, Hai-Ren Zhang, Wonsuk Chang, Bruce S Ross

Nucleosides Nucleotides Nucleic Acids· November 2011

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Synthesis of diastereomerically pure nucleotide phosphoramidates.
Bruce S Ross, P Ganapati Reddy, Hai-Ren Zhang, Suguna Rachakonda, Michael J Sofia

J Org Chem· October 2011

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Activity and the metabolic activation pathway of the potent and selective hepatitis C virus pronucleotide inhibitor PSI-353661.
Phillip A Furman, Eisuke Murakami, Congrong Niu, Angela M Lam, Christine Espiritu, Bruce S Ross

Antiviral Res· August 2011

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Stereoselective synthesis of PSI-352938: a β-D-2'-deoxy-2'-α-fluoro-2'-β-C-methyl-3',5'-cyclic phosphate nucleotide prodrug for the treatment of HCV.
P Ganapati Reddy, Byoung-Kwon Chun, Hai-Ren Zhang, Suguna Rachakonda, Bruce S Ross

J Org Chem· May 2011

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Discovery of PSI-353661, a Novel Purine Nucleotide Prodrug for the Treatment of HCV Infection.
Wonsuk Chang, Donghui Bao, Byoung-Kwon Chun, Devan Naduthambi, Dhanapalan Nagarathnam, Bruce S Ross

ACS Med Chem Lett· February 2011

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2'-deoxy-2'-α-fluoro-2'-β-C-methyl 3',5'-cyclic phosphate nucleotide prodrug analogs as inhibitors of HCV NS5B polymerase: discovery of PSI-352938.
P Ganapati Reddy, Donghui Bao, Wonsuk Chang, Byoung-Kwon Chun, Jinfa Du, Bruce S Ross

Bioorg Med Chem Lett· December 2010

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Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus.
Michael J Sofia, Donghui Bao, Wonsuk Chang, Jinfa Du, Dhanapalan Nagarathnam, Bruce S Ross

J Med Chem· October 2010

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PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication.
Angela M Lam, Eisuke Murakami, Christine Espiritu, Holly M Micolochick Steuer, Congrong Niu, Bruce S Ross

Antimicrob Agents Chemother· August 2010

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Synthesis and anti-HCV activity of 3',4'-oxetane nucleosides.
Wonsuk Chang, Jinfa Du, Suguna Rachakonda, Bruce S Ross, Serge Convers-Reignier

Bioorg Med Chem Lett· August 2010

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An efficient and diastereoselective synthesis of PSI-6130: a clinically efficacious inhibitor of HCV NS5B polymerase.
Peiyuan Wang, Byoung-Kwon Chun, Suguna Rachakonda, Jinfa Du, Noshena Khan, Bruce S Ross

J Org Chem· September 2009

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Process research on the preparation of DMT protected 2'-O-methoxyethylguanosine for oligonucleotide synthesis in therapeutic applications.
Shabbir Ali S Taj, S Narayanan, S Suman Meenakshi, Yogesh S Sanghvi, Bruce S Ross

Nucleosides Nucleotides Nucleic Acids· September 2008

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Comparing in vitro and in vivo activity of 2'-O-[2-(methylamino)-2-oxoethyl]- and 2'-O-methoxyethyl-modified antisense oligonucleotides.
Thazha P Prakash, Andrew M Kawasaki, Edward V Wancewicz, Lijiang Shen, Brett P Monia, Bruce S Ross

J Med Chem· May 2008

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An efficient and scalable synthesis of 2,6-diaminopurine riboside.
Bruce S Ross, Robert H Springer, Vasulinga T Ravikumar

Nucleosides Nucleotides Nucleic Acids· January 2008

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Efficient large-scale synthesis of 5'-O-dimethoxytrityl-N4-benzoyl-5-methyl-2'-deoxycytidine.
Bruce S Ross, Mingming Han, Vasulinga T Ravikumar

Nucleosides Nucleotides Nucleic Acids· September 2006

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Kilo-scale synthesis process for 2'-O-(2-methoxyethyl)-pyrimidine derivatives.
Bruce S Ross, Quanlai Song, Mingming Han

Nucleosides Nucleotides Nucleic Acids· December 2005

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Probing the influence of stereoelectronic effects on the biophysical properties of oligonucleotides: comprehensive analysis of the RNA affinity, nuclease resistance, and crystal structure of ten 2'-O-ribonucleic acid modifications.
Martin Egli, George Minasov, Valentina Tereshko, Pradeep S Pallan, Marianna Teplova, Bruce S Ross

Biochemistry· June 2005

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Commercial-scale synthesis of protected 2'-deoxycytidine and cytidine nucleosides.
Kikkeri J Divakar, Chitra M Sawant, Y A Mulla, Deepak V Zemse, Sakina M Sitabkhan, Bruce S Ross

Nucleosides Nucleotides Nucleic Acids· December 2003

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