Publications by authors named "Bruno D Chapsal"

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Design of Potent Menin-KMT2A Interaction Inhibitors with Improved ADME Properties and Reduced hERG Affinity.
Bruno D Chapsal, Jennifer R Kimbrough, Stephanie M Bester, Alex Bergstrom, Donald S Backos

ACS Med Chem Lett· February 2025

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Discovery of 5-Azaquinoxaline Derivatives as Potent and Orally Bioavailable Allosteric SHP2 Inhibitors.
Mohamed S A Elsayed, James F Blake, Mark L Boys, Eric Brown, Bruno D Chapsal

ACS Med Chem Lett· December 2023

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Substituent effects on P2-cyclopentyltetrahydrofuranyl urethanes: design, synthesis, and X-ray studies of potent HIV-1 protease inhibitors.
Arun K Ghosh, Bruno D Chapsal, Melinda Steffey, Johnson Agniswamy, Yuan-Fang Wang

Bioorg Med Chem Lett· March 2012

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Design of HIV-1 protease inhibitors with C3-substituted hexahydrocyclopentafuranyl urethanes as P2-ligands: synthesis, biological evaluation, and protein-ligand X-ray crystal structure.
Arun K Ghosh, Bruno D Chapsal, Garth L Parham, Melinda Steffey, Johnson Agniswamy

J Med Chem· August 2011

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Design and synthesis of potent HIV-1 protease inhibitors incorporating hexahydrofuropyranol-derived high affinity P(2) ligands: structure-activity studies and biological evaluation.
Arun K Ghosh, Bruno D Chapsal, Abigail Baldridge, Melinda P Steffey, D Eric Walters

J Med Chem· January 2011

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Design and synthesis of stereochemically defined novel spirocyclic P2-ligands for HIV-1 protease inhibitors.
Arun K Ghosh, Bruno D Chapsal, Abigail Baldridge, Kazuhiko Ide, Yashiro Koh

Org Lett· November 2008

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Design of HIV protease inhibitors targeting protein backbone: an effective strategy for combating drug resistance.
Arun K Ghosh, Bruno D Chapsal, Irene T Weber, Hiroaki Mitsuya

Acc Chem Res· January 2008

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Total synthesis of enantiopure (+)-gamma-lycorane using highly efficient Pd-catalyzed asymmetric allylic alkylation.
Bruno D Chapsal, Iwao Ojima

Org Lett· March 2006

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