Publications by authors named "Bruno D Fonseca"

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The amino acid sensor GCN2 suppresses terminal oligopyrimidine (TOP) mRNA translation via La-related protein 1 (LARP1).
Zeenat Farooq, Fedho Kusuma, Phillip Burke, Catherine R Dufour, Duckgue Lee, Bruno D Fonseca

J Biol Chem· September 2022

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mTORC1 promotes TOP mRNA translation through site-specific phosphorylation of LARP1.
Jian-Jun Jia, Roni M Lahr, Michael T Solgaard, Bruno J Moraes, Roberta Pointet, Bruno D Fonseca

Nucleic Acids Res· April 2021

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The isolated La-module of LARP1 mediates 3' poly(A) protection and mRNA stabilization, dependent on its intrinsic PAM2 binding to PABPC1.
Sandy Mattijssen, Guennadi Kozlov, Sergei Gaidamakov, Amitabh Ranjan, Bruno D Fonseca

RNA Biol· February 2021

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LARP1 and LARP4: up close with PABP for mRNA 3' poly(A) protection and stabilization.
Sandy Mattijssen, Guennadi Kozlov, Bruno D Fonseca, Kalle Gehring, Richard J Maraia

RNA Biol· February 2021

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The mTOR regulated RNA-binding protein LARP1 requires PABPC1 for guided mRNA interaction.
Ewan M Smith, Nour El Houda Benbahouche, Katherine Morris, Ania Wilczynska, Sarah Gillen, Bruno D Fonseca

Nucleic Acids Res· January 2021

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Capturing the Mechanism Underlying TOP mRNA Binding to LARP1.
Kevin C Cassidy, Roni M Lahr, Jesse C Kaminsky, Stephanie Mack, Bruno D Fonseca

Structure· December 2019

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LARP1 on TOP of ribosome production.
Bruno D Fonseca, Roni M Lahr, Christian K Damgaard, Tommy Alain, Andrea J Berman

Wiley Interdiscip Rev RNA· September 2018

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The Protozoan Parasite Toxoplasma gondii Selectively Reprograms the Host Cell Translatome.
Louis-Philippe Leroux, Julie Lorent, Tyson E Graber, Visnu Chaparro, Laia Masvidal, Bruno D Fonseca

Infect Immun· September 2018

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La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs.
Roni M Lahr, Bruno D Fonseca, Gabrielle E Ciotti, Hiba A Al-Ashtal, Jian-Jun Jia

Elife· April 2017

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Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3.
Yoshinori Tsukumo, Tommy Alain, Bruno D Fonseca, Robert Nadon, Nahum Sonenberg

Nat Commun· June 2016

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S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3.
Fuan Wang, Tommy Alain, Kristy J Szretter, Kyle Stephenson, Jonathan G Pol, Bruno D Fonseca

Nat Immunol· May 2016

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La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1).
Bruno D Fonseca, Chadi Zakaria, Jian-Jun Jia, Tyson E Graber, Yuri Svitkin

J Biol Chem· June 2015

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The ever-evolving role of mTOR in translation.
Bruno D Fonseca, Ewan M Smith, Nicolas Yelle, Tommy Alain, Martin Bushell

Semin Cell Dev Biol· December 2014

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eIF4E/4E-BP ratio predicts the efficacy of mTOR targeted therapies.
Tommy Alain, Masahiro Morita, Bruno D Fonseca, Akiko Yanagiya, Nadeem Siddiqui

Cancer Res· December 2012

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A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development.
Masahiro Morita, Lian Wee Ler, Marc R Fabian, Nadeem Siddiqui, Michael Mullin, Bruno D Fonseca

Mol Cell Biol· September 2012

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Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling.
Bruno D Fonseca, Graham H Diering, Michael A Bidinosti, Kush Dalal, Tommy Alain

J Biol Chem· May 2012

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Regulation of mTORC1 signaling by pH.
Aruna D Balgi, Graham H Diering, Elizabeth Donohue, Karen K Y Lam, Bruno D Fonseca

PLoS One· December 2011

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Pharmacological and genetic evaluation of proposed roles of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK), extracellular signal-regulated kinase (ERK), and p90(RSK) in the control of mTORC1 protein signaling by phorbol esters.
Bruno D Fonseca, Tommy Alain, Leona K Finestone, Brandon P H Huang, Mark Rolfe

J Biol Chem· August 2011

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mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs.
Ryan J O Dowling, Ivan Topisirovic, Tommy Alain, Michael Bidinosti, Bruno D Fonseca

Science· May 2010

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Dissecting the role of mTOR: lessons from mTOR inhibitors.
Ryan J O Dowling, Ivan Topisirovic, Bruno D Fonseca, Nahum Sonenberg

Biochim Biophys Acta· March 2010

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Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling.
Aruna D Balgi, Bruno D Fonseca, Elizabeth Donohue, Trevor C F Tsang, Patrick Lajoie

PLoS One· September 2009

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Re-evaluating the roles of proposed modulators of mammalian target of rapamycin complex 1 (mTORC1) signaling.
Xuemin Wang, Bruno D Fonseca, Hua Tang, Rui Liu, Androulla Elia

J Biol Chem· November 2008

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Analysis of the regulatory motifs in eukaryotic initiation factor 4E-binding protein 1.
Vivian H Y Lee, Timothy Healy, Bruno D Fonseca, Amanda Hayashi, Christopher G Proud

FEBS J· May 2008

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The binding of PRAS40 to 14-3-3 proteins is not required for activation of mTORC1 signalling by phorbol esters/ERK.
Bruno D Fonseca, Vivian H-Y Lee, Christopher G Proud

Biochem J· April 2008

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PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex.
Bruno D Fonseca, Ewan M Smith, Vivian H-Y Lee, Carol MacKintosh, Christopher G Proud

J Biol Chem· August 2007

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