Publications by authors named "Bruno Kyewski"

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Conventional and Neo-antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors.
Sergio Gonzalez-Duque, Marie Eliane Azoury, Maikel L Colli, Georgia Afonso, Jean-Valery Turatsinze, Bruno Kyewski

Cell Metab· December 2018

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Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development.
Corey N Miller, Irina Proekt, Jakob von Moltke, Kristen L Wells, Aparna R Rajpurkar, Bruno Kyewski

Nature· July 2018

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An efficient protocol for in vivo labeling of proliferating epithelial cells.
Chloé Michel, Rita Küchler, Iris Martin, Bruno Kyewski, Sheena Pinto

J Immunol Methods· June 2018

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Islet-reactive CD8 T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors.
Slobodan Culina, Ana Ines Lalanne, Georgia Afonso, Karen Cerosaletti, Sheena Pinto, Bruno Kyewski

Sci Immunol· February 2018

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T cells specific for post-translational modifications escape intrathymic tolerance induction.
Bruno Raposo, Patrick Merky, Christina Lundqvist, Hisakata Yamada, Vilma Urbonaviciute, Bruno Kyewski

Nat Commun· January 2018

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Revisiting the Road Map of Medullary Thymic Epithelial Cell Differentiation.
Chloé Michel, Corey N Miller, Rita Küchler, Benedikt Brors, Mark S Anderson, Bruno Kyewski

J Immunol· November 2017

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Epitope-Specific Tolerance Modes Differentially Specify Susceptibility to Proteolipid Protein-Induced Experimental Autoimmune Encephalomyelitis.
Lei Wang, Julia Winnewisser, Christine Federle, Gregor Jessberger, Klaus-Armin Nave, Bruno Kyewski

Front Immunol· November 2017

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Dissecting and modeling the emergent murine TEC compartment during ontogeny.
Fabian Brunk, Chloé Michel, Tim Holland-Letz, Alla Slynko, Annette Kopp-Schneider, Bruno Kyewski

Eur J Immunol· July 2017

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A Thymic Epithelial Stem Cell Pool Persists throughout Ontogeny and Is Modulated by TGF-β.
Olga Ucar, Kaiyong Li, Dmytro Dvornikov, Clemens Kreutz, Jens Timmer, Bruno Kyewski

Cell Rep· October 2016

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Myelin oligodendrocyte glycoprotein induces incomplete tolerance of CD4(+) T cells specific for both a myelin and a neuronal self-antigen in mice.
Liliana E Lucca, Pierre-Paul Axisa, Meryem Aloulou, Corine Perals, Abdulraouf Ramadan, Bruno Kyewski

Eur J Immunol· September 2016

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Pillars Article: Promiscuous Gene Expression in Medullary Thymic Epithelial Cells Mirrors the Peripheral Self. Nat. Immunol. 2001. 2: 1032-1039.
Jens Derbinski, Antje Schulte, Bruno Kyewski, Ludger Klein

J Immunol· April 2016

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Evolutionary conserved gene co-expression drives generation of self-antigen diversity in medullary thymic epithelial cells.
Kristin Rattay, Hannah Verena Meyer, Carl Herrmann, Benedikt Brors, Bruno Kyewski

J Autoimmun· February 2016

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Re-examining the Nature and Function of Self-Reactive T cells.
David M Richards, Bruno Kyewski, Markus Feuerer

Trends Immunol· February 2016

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Thymic Epithelial Cells Are a Nonredundant Source of Wnt Ligands for Thymus Development.
Fabian Brunk, Iris Augustin, Michael Meister, Michael Boutros, Bruno Kyewski

J Immunol· December 2015

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Genome-wide gene expression profiling of homeodomain-interacting protein kinase 2 deficient medullary thymic epithelial cells.
Kristin Rattay, Jens Derbinski, Thomas G Hofmann, Bruno Kyewski

Genom Data· December 2015

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Materno-Fetal Transfer of Preproinsulin Through the Neonatal Fc Receptor Prevents Autoimmune Diabetes.
Slobodan Culina, Nimesh Gupta, Raphael Boisgard, Georgia Afonso, Marie-Claude Gagnerault, Bruno Kyewski

Diabetes· October 2015

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Single-cell transcriptome analysis reveals coordinated ectopic gene-expression patterns in medullary thymic epithelial cells.
Philip Brennecke, Alejandro Reyes, Sheena Pinto, Kristin Rattay, Michelle Nguyen, Bruno Kyewski

Nat Immunol· September 2015

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3D Organotypic Co-culture Model Supporting Medullary Thymic Epithelial Cell Proliferation, Differentiation and Promiscuous Gene Expression.
Sheena Pinto, Hans-Jürgen Stark, Iris Martin, Petra Boukamp, Bruno Kyewski

J Vis Exp· July 2015

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Central T cell tolerance: Identification of tissue-restricted autoantigens in the thymus HLA-DR peptidome.
Iñaki Alvarez, Javier A Collado, Roger Colobran, Montserrat Carrascal, M Teresa Ciudad, Bruno Kyewski

J Autoimmun· June 2015

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Thymic B Cells Are Licensed to Present Self Antigens for Central T Cell Tolerance Induction.
Tomoyoshi Yamano, Jelena Nedjic, Maria Hinterberger, Madlen Steinert, Sandra Koser, Bruno Kyewski

Immunity· June 2015

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Homeodomain-interacting protein kinase 2, a novel autoimmune regulator interaction partner, modulates promiscuous gene expression in medullary thymic epithelial cells.
Kristin Rattay, Janine Claude, Esmail Rezavandy, Sonja Matt, Thomas G Hofmann, Bruno Kyewski

J Immunol· February 2015

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Misinitiation of intrathymic MART-1 transcription and biased TCR usage explain the high frequency of MART-1-specific T cells.
Sheena Pinto, Daniel Sommermeyer, Chloé Michel, Susanne Wilde, Dolores Schendel, Bruno Kyewski

Eur J Immunol· September 2014

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Love is in the Aire: mTECs share their assets.
Bruno Kyewski, Markus Feuerer

Immunity· September 2014

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Adult thymus contains FoxN1(-) epithelial stem cells that are bipotent for medullary and cortical thymic epithelial lineages.
Ahmet Ucar, Olga Ucar, Paula Klug, Sonja Matt, Fabian Brunk, Bruno Kyewski

Immunity· August 2014

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Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see).
Ludger Klein, Bruno Kyewski, Paul M Allen, Kristin A Hogquist

Nat Rev Immunol· June 2014

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