Publications by authors named "Bryan D Smith"

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Combining VPS34 inhibitors with STING agonists enhances type I interferon signaling and anti-tumor efficacy.
Yasmin Yu, Madhumita Bogdan, Muhammad Zaeem Noman, Santiago Parpal, Elisabetta Bartolini, Bryan D Smith

Mol Oncol· August 2024

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Inhibition of ULK1/2 and KRAS controls tumor growth in preclinical models of lung cancer.
Phaedra C Ghazi, Kayla T O'Toole, Sanjana Srinivas Boggaram, Michael T Scherzer, Mark R Silvis, Bryan D Smith

Elife· August 2024

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Inhibition of ULK1/2 and KRAS controls tumor growth in preclinical models of lung cancer.
Phaedra C Ghazi, Kayla T O'Toole, Sanjana Srinivas Boggaram, Michael T Scherzer, Mark R Silvis, Bryan D Smith

bioRxiv· June 2024

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The MOTION study: a randomized, phase III study of vimseltinib for the treatment of tenosynovial giant cell tumor.
William D Tap, Maitreyi G Sharma, Marc Vallee, Bryan D Smith, Matthew L Sherman

Future Oncol· March 2024

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Discovery of vimseltinib (DCC-3014), a highly selective CSF1R switch-control kinase inhibitor, in clinical development for the treatment of Tenosynovial Giant Cell Tumor (TGCT).
Timothy M Caldwell, Yu Mi Ahn, Stacie L Bulfer, Cynthia B Leary, Molly M Hood, Bryan D Smith

Bioorg Med Chem Lett· October 2022

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Discovery of acyl ureas as highly selective small molecule CSF1R kinase inhibitors.
Timothy M Caldwell, Michael D Kaufman, Scott C Wise, Yu Mi Ahn, Molly M Hood, Bryan D Smith

Bioorg Med Chem Lett· October 2022

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Vimseltinib: A Precision CSF1R Therapy for Tenosynovial Giant Cell Tumors and Diseases Promoted by Macrophages.
Bryan D Smith, Michael D Kaufman, Scott C Wise, Yu Mi Ahn, Timothy M Caldwell

Mol Cancer Ther· November 2021

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Ripretinib and MEK Inhibitors Synergize to Induce Apoptosis in Preclinical Models of GIST and Systemic Mastocytosis.
Anu Gupta, Jarnail Singh, Alfonso García-Valverde, César Serrano, Daniel L Flynn, Bryan D Smith

Mol Cancer Ther· July 2021

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Ripretinib (DCC-2618) Is a Switch Control Kinase Inhibitor of a Broad Spectrum of Oncogenic and Drug-Resistant KIT and PDGFRA Variants.
Bryan D Smith, Michael D Kaufman, Wei-Ping Lu, Anu Gupta, Cynthia B Leary

Cancer Cell· May 2019

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The Selective Tie2 Inhibitor Rebastinib Blocks Recruitment and Function of Tie2 Macrophages in Breast Cancer and Pancreatic Neuroendocrine Tumors.
Allison S Harney, George S Karagiannis, Jeanine Pignatelli, Bryan D Smith, Ece Kadioglu

Mol Cancer Ther· November 2017

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Phase 1 dose-finding study of rebastinib (DCC-2036) in patients with relapsed chronic myeloid leukemia and acute myeloid leukemia.
Jorge Cortes, Moshe Talpaz, Hedy P Smith, David S Snyder, Jean Khoury, Bryan D Smith

Haematologica· March 2017

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Novel MET/TIE2/VEGFR2 inhibitor altiratinib inhibits tumor growth and invasiveness in bevacizumab-resistant glioblastoma mouse models.
Yuji Piao, Soon Young Park, Verlene Henry, Bryan D Smith, Ningyi Tiao

Neuro Oncol· September 2016

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Altiratinib Inhibits Tumor Growth, Invasion, Angiogenesis, and Microenvironment-Mediated Drug Resistance via Balanced Inhibition of MET, TIE2, and VEGFR2.
Bryan D Smith, Michael D Kaufman, Cynthia B Leary, Benjamin A Turner, Scott C Wise

Mol Cancer Ther· September 2015

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Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers.
Sheng-Bin Peng, James R Henry, Michael D Kaufman, Wei-Ping Lu, Bryan D Smith

Cancer Cell· September 2015

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Discovery of 1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea (LY3009120) as a pan-RAF inhibitor with minimal paradoxical activation and activity against BRAF or RAS mutant tumor cells.
James R Henry, Michael D Kaufman, Sheng-Bin Peng, Yu Mi Ahn, Timothy M Caldwell, Bryan D Smith

J Med Chem· May 2015

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Site-specific folate conjugation to a cytotoxic protein.
Bryan D Smith, Joshua J Higgin, Ronald T Raines

Bioorg Med Chem Lett· September 2011

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The ABL switch control inhibitor DCC-2036 is active against the chronic myeloid leukemia mutant BCR-ABLT315I and exhibits a narrow resistance profile.
Christopher A Eide, Lauren T Adrian, Jeffrey W Tyner, Mary Mac Partlin, David J Anderson, Bryan D Smith

Cancer Res· May 2011

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Conformational control inhibition of the BCR-ABL1 tyrosine kinase, including the gatekeeper T315I mutant, by the switch-control inhibitor DCC-2036.
Wayne W Chan, Scott C Wise, Michael D Kaufman, Yu Mi Ahn, Carol L Ensinger, Bryan D Smith

Cancer Cell· April 2011

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Functional and structural analyses of N-acylsulfonamide-linked dinucleoside inhibitors of RNase A.
Nethaji Thiyagarajan, Bryan D Smith, Ronald T Raines, K Ravi Acharya

FEBS J· February 2011

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Switch control pocket inhibitors of p38-MAP kinase. Durable type II inhibitors that do not require binding into the canonical ATP hinge region.
Yu Mi Ahn, Michael Clare, Carol L Ensinger, Molly M Hood, John W Lord, Bryan D Smith

Bioorg Med Chem Lett· October 2010

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Genetic selection for peptide inhibitors of angiogenin.
Bryan D Smith, Ronald T Raines

Protein Eng Des Sel· May 2008

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Genetic selection for critical residues in ribonucleases.
Bryan D Smith, Ronald T Raines

J Mol Biol· September 2006

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Synthetic surfaces for ribonuclease adsorption.
Bryan D Smith, Matthew B Soellner, Ronald T Raines

Langmuir· January 2005

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Potent inhibition of ribonuclease A by oligo(vinylsulfonic acid).
Bryan D Smith, Matthew B Soellner, Ronald T Raines

J Biol Chem· June 2003

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Synthesis and Characterization of Isostructural Metalloporphyrin Chalconitrosyl Complexes Ru(TTP)(NE)Cl (E = O, S) and a Remarkable Thionitrosyl/Nitrite --> Nitrosyl/Thiazate Transformation.
D. Scott Bohle, Chen-Hsiung Hung, Annie K. Powell, Bryan D. Smith, Sigrid Wocadlo

Inorg Chem· May 1997

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