Publications by authors named "Caiyu Lin"

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Dapk2 dysfunction leads to Mic60 lactylation and mitochondrial metabolic reprogramming, promoting lung cancer EGFR-TKI resistance and metastasis.
Jie Zheng, Han She, Rui Han, Ju Tang, Yuanyao Dou, Caiyu Lin

Dev Cell· December 2025

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Imidazole propionate ameliorates lipid metabolism in adipocytes to attenuate high-fat diet-induced obesity via PPAR signaling pathway.
Caiyu Lin, Zhou Peng, Juan Du, Xiaoyu Shan, Zhongxiao Zhang, Liling Xu

Lipids Health Dis· November 2025

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Human milk-derived 5'-UMP promotes thermogenesis and mitochondrial biogenesis to ameliorate obesity.
Ling Zhang, Zhou Peng, Caiyu Lin, Haixia Hu, Juan Du

Front Nutr· October 2025

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Anti-EGFR therapy can overcome acquired resistance to the third-generation ALK-tyrosine kinase inhibitor lorlatinib mediated by activation of EGFR.
Chen Hu, Cong-Hua Lu, Jie Zheng, Jun Kang, Dai-Juan Huang, Cai-Yu Lin

Acta Pharmacol Sin· August 2025

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Multieffect Specific Nanovesicles for Homing Resistant Tumors and Overcoming Osimertinib-Acquired Resistance in NSCLC.
Yuanyao Dou, Yihui Liu, Rui Han, Jie Zheng, Liping Wang, Caiyu Lin, Liling Tang

Adv Healthc Mater· April 2025

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Metformin promotes anti-tumor immunity in mutant NSCLC through AXIN1-dependent upregulation of multiple nucleotide metabolites.
Zhiguo Wang, Kunlin Li, Conghua Lu, Mingxia Feng, Caiyu Lin

Oncol Res· September 2024

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Mesoporous manganese nanocarrier target delivery metformin for the co-activation STING pathway to overcome immunotherapy resistance.
Yuanyao Dou, Jie Zheng, Jun Kang, Liping Wang, Daijuan Huang, Caiyu Lin, Liling Tang

iScience· July 2024

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Brigatinib, a newly discovered AXL inhibitor, suppresses AXL-mediated acquired resistance to osimertinib in EGFR-mutated non-small cell lung cancer.
Rui Han, Cong-Hua Lu, Chen Hu, Yuan-Yao Dou, Jun Kang, Cai-Yu Lin, Wei-Ling Jiang

Acta Pharmacol Sin· June 2024

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Understanding the dynamics of TKI-induced changes in the tumor immune microenvironment for improved therapeutic effect.
Conghua Lu, Ziyuan Gao, Di Wu, Jie Zheng, Chen Hu, Caiyu Lin, Weiling Jiang

J Immunother Cancer· June 2024

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AXIN1/MYC Axis Mediated the Osimertinib Resistance in EGFR Mutant Non-Small Cell Lung Cancer Cells.
Haoyue Yu, Zhiguo Wang, Yan Dong, Li Li, Xianming Fan, Caiyu Lin, Kunlin Li

Tohoku J Exp Med· May 2024

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Sialyltransferase ST3GAL4 confers osimertinib resistance and offers strategies to overcome resistance in non-small cell lung cancer.
Rui Han, Caiyu Lin, Conghua Lu, Yubo Wang, Jun Kang

Cancer Lett· April 2024

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Overall signature of acquired KRAS gene changes in advanced non-small cell lung cancer patient with EGFR-TKI resistance.
Jie Zheng, Yuanyao Dou, Daijuan Huang, Yubo Wang, Rui Han, Caiyu Lin, Weilin Jiang

Jpn J Clin Oncol· January 2024

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The potential therapeutic regimen for overcoming resistance to osimertinib due to rare mutations in NSCLC.
Rui Han, Caiyu Lin, Chong Zhang, Jun Kang, Conghua Lu

iScience· July 2023

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Predictive value of early kinetics of ctDNA combined with cfDNA and serum CEA for EGFR-TKI treatment in advanced non-small cell lung cancer.
Jie Zheng, Yubo Wang, Chen Hu, Mengxiao Zhu, Jianghua Ii, Caiyu Lin

Thorac Cancer· November 2022

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pH-responsive theranostic nanoplatform of ferrite and ceria co-engineered nanoparticles for anti-inflammatory.
Yuanyao Dou, Yimin Zhang, Caiyu Lin, Rui Han, Yubo Wang, Liling Tang

Front Bioeng Biotechnol· September 2022

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Protective autophagy decreases lorlatinib cytotoxicity through Foxo3a-dependent inhibition of apoptosis in NSCLC.
Conghua Lu, Rui Yu, Chong Zhang, Caiyu Lin, Yuanyao Dou

Cell Death Discov· April 2022

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Ibrutinib reverses IL-6-induced osimertinib resistance through inhibition of Laminin α5/FAK signaling.
Li Li, Zhujun Li, Conghua Lu, Jianghua Li, Kejun Zhang, Caiyu Lin, Xiaolin Tang, Zhulin Liu

Commun Biol· February 2022

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Metformin Combining PD-1 Inhibitor Enhanced Anti-Tumor Efficacy in Mutant Lung Cancer Through AXIN-1-Dependent Inhibition of STING Ubiquitination.
Zhiguo Wang, Conghua Lu, Kejun Zhang, Caiyu Lin, Fang Wu, Xiaolin Tang

Front Mol Biosci· February 2022

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Hexokinases II-mediated glycolysis governs susceptibility to crizotinib in ALK-positive non-small cell lung cancer.
Caiyu Lin, Hengyi Chen, Rui Han, Li Li, Conghua Lu

Thorac Cancer· December 2021

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VPS34 suppression reverses osimertinib resistance via simultaneously inhibiting glycolysis and autophagy.
Hengyi Chen, Conghua Lu, Caiyu Lin, Li Li, Yubo Wang

Carcinogenesis· June 2021

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Biological Significance of F-FDG PET/CT Maximum Standard Uptake Value for Predicting Mutation Status in Non-Small Cell Lung Cancer Patients.
Yubo Wang, Rui Han, Qiushi Wang, Jie Zheng, Caiyu Lin

Int J Gen Med· February 2021

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Aspirin sensitizes osimertinib-resistant NSCLC cells in vitro and in vivo via Bim-dependent apoptosis induction.
Rui Han, Shuai Hao, Conghua Lu, Chong Zhang, Caiyu Lin

Mol Oncol· June 2020

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Metformin attenuates TGF-β1-induced pulmonary fibrosis through inhibition of transglutaminase 2 and subsequent TGF-β pathways.
Yubo Wang, Caiyu Lin, Rui Han, Conghua Lu, Li Li

3 Biotech· June 2020

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Metformin reduces HGF-induced resistance to alectinib via the inhibition of Gab1.
Hengyi Chen, Caiyu Lin, Tao Peng, Cheng Hu, Conghua Lu

Cell Death Dis· February 2020

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Metformin-sensitized NSCLC cells to osimertinib via AMPK-dependent autophagy inhibition.
Hengyi Chen, Caiyu Lin, Conghua Lu, Yubo Wang, Rui Han

Clin Respir J· December 2019

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