Publications by authors named "Caleb Webber"

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Changes in neural progenitor lineage composition during astrocytic differentiation of human iPSCs.
Zongze Li, Lucia Fernandez Cardo, Michal Rokicki, Jimena Monzón-Sandoval, Viola Volpato, Caleb Webber

Elife· October 2025

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Modeling common Alzheimer's disease with high and low polygenic risk in human iPSC: A large-scale research resource.
Emily Maguire, Jincy Winston, Sarah H Ellwood, Rachel O'Donoghue, Bethany Shaw, Caleb Webber

Stem Cell Reports· August 2025

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The solute carrier SLC7A1 may act as a protein transporter at the blood-brain barrier.
Magdalena Kurtyka, Frank Wessely, Sarah Bau, Eseoghene Ifie, Liqun He, Caleb Webber

Eur J Cell Biol· June 2024

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Demultiplexing of single-cell RNA-sequencing data using interindividual variation in gene expression.
Isar Nassiri, Andrew J Kwok, Aneesha Bhandari, Katherine R Bull, Lucy C Garner, Caleb Webber

Bioinform Adv· June 2024

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A single nuclear transcriptomic characterisation of mechanisms responsible for impaired angiogenesis and blood-brain barrier function in Alzheimer's disease.
Stergios Tsartsalis, Hannah Sleven, Nurun Fancy, Frank Wessely, Amy M Smith, Caleb Webber

Nat Commun· March 2024

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Single-Cell Transcriptomics and In Vitro Lineage Tracing Reveals Differential Susceptibility of Human iPSC-Derived Midbrain Dopaminergic Neurons in a Cellular Model of Parkinson's Disease.
Lucia F Cardo, Jimena Monzón-Sandoval, Zongze Li, Caleb Webber, Meng Li

Cells· December 2023

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A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia.
Sarmi Sri, Adam Greenstein, Alessandra Granata, Alex Collcutt, Angela C C Jochems, Caleb Webber

Cereb Circ Cogn Behav· October 2023

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Single-Cell Transcriptomics Reveals Conserved Regulatory Networks in Human and Mouse Interneuron Development.
Francesca Keefe, Jimena Monzón-Sandoval, Anne E Rosser, Caleb Webber, Meng Li

Int J Mol Sci· May 2023

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Common and Rare Variants in TMEM175 Gene Concur to the Pathogenesis of Parkinson's Disease in Italian Patients.
Nicole Piera Palomba, Giorgio Fortunato, Giuseppe Pepe, Nicola Modugno, Sara Pietracupa, Caleb Webber

Mol Neurobiol· April 2023

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Single-Nuclei RNA Sequencing of 5 Regions of the Human Prenatal Brain Implicates Developing Neuron Populations in Genetic Risk for Schizophrenia.
Darren Cameron, Da Mi, Ngoc-Nga Vinh, Caleb Webber, Meng Li

Biol Psychiatry· January 2023

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Universal clinical Parkinson's disease axes identify a major influence of neuroinflammation.
Cynthia Sandor, Stephanie Millin, Andrew Dahl, Ann-Kathrin Schalkamp, Michael Lawton, Caleb Webber

Genome Med· November 2022

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Lipopolysaccharide distinctively alters human microglia transcriptomes to resemble microglia from Alzheimer's disease mouse models.
Jimena Monzón-Sandoval, Elena Burlacu, Devika Agarwal, Adam E Handel, Liting Wei, Caleb Webber

Dis Model Mech· October 2022

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Combining multiomics and drug perturbation profiles to identify muscle-specific treatments for spinal muscular atrophy.
Katharina E Meijboom, Viola Volpato, Jimena Monzón-Sandoval, Joseph M Hoolachan, Suzan M Hammond, Caleb Webber

JCI Insight· July 2021

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Targeted single-cell RNA sequencing of transcription factors enhances the identification of cell types and trajectories.
Alexandra Pokhilko, Adam E Handel, Fabiola Curion, Viola Volpato, Emma S Whiteley, Caleb Webber

Genome Res· June 2021

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The Parkinson's Disease Genome-Wide Association Study Locus Browser.
Francis P Grenn, Jonggeol J Kim, Mary B Makarious, Hirotaka Iwaki, Anastasia Illarionova, Caleb Webber

Mov Disord· November 2020

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TREM2 Alzheimer's variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages.
Hazel Hall-Roberts, Devika Agarwal, Juliane Obst, Thomas B Smith, Jimena Monzón-Sandoval, Caleb Webber

Alzheimers Res Ther· November 2020

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Dystonia genes functionally converge in specific neurons and share neurobiology with psychiatric disorders.
Niccolò E Mencacci, Regina Reynolds, Sonia Garcia Ruiz, Jana Vandrovcova, Paola Forabosco, Caleb Webber

Brain· September 2020

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A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders.
Devika Agarwal, Cynthia Sandor, Viola Volpato, Tara M Caffrey, Jimena Monzón-Sandoval, Caleb Webber

Nat Commun· August 2020

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Pro-maturational Effects of Human iPSC-Derived Cortical Astrocytes upon iPSC-Derived Cortical Neurons.
Anne Hedegaard, Jimena Monzón-Sandoval, Sarah E Newey, Emma S Whiteley, Caleb Webber

Stem Cell Reports· July 2020

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Human-Specific Transcriptome of Ventral and Dorsal Midbrain Dopamine Neurons.
Jimena Monzón-Sandoval, Ilaria Poggiolini, Tobias Ilmer, Richard Wade-Martins, Caleb Webber

Ann Neurol· June 2020

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Deep phenotyping of peripheral tissue facilitates mechanistic disease stratification in sporadic Parkinson's disease.
Phillippa J Carling, Heather Mortiboys, Claire Green, Simeon Mihaylov, Cynthia Sandor, Caleb Webber

Prog Neurobiol· April 2020

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Genome-Wide Association Study of Pain in Parkinson's Disease Implicates TRPM8 as a Risk Factor.
Nigel M Williams, Leon Hubbard, Cynthia Sandor, Caleb Webber, Hannah Hendry

Mov Disord· April 2020

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Addressing variability in iPSC-derived models of human disease: guidelines to promote reproducibility.
Viola Volpato, Caleb Webber

Dis Model Mech· January 2020

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CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice.
Renzo Mancuso, Gemma Fryatt, Madeleine Cleal, Juliane Obst, Elena Pipi, Caleb Webber

Brain· October 2019

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Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis.
Stephan C Collins, Anna Mikhaleva, Katarina Vrcelj, Valerie E Vancollie, Christel Wagner, Caleb Webber

Nat Commun· August 2019

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