Publications by authors named "Carl Frieden"

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Apolipoprotein E4 has extensive conformational heterogeneity in lipid-free and lipid-bound forms.
Melissa D Stuchell-Brereton, Maxwell I Zimmerman, Justin J Miller, Upasana L Mallimadugula, J Jeremías Incicco, Carl Frieden

Proc Natl Acad Sci U S A· February 2023

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-Jacksonville (V236E) variant reduces self-aggregation and risk of dementia.
Chia-Chen Liu, Melissa E Murray, Xia Li, Na Zhao, Na Wang, Carl Frieden

Sci Transl Med· September 2021

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Bioorthogonal Chemistry Enables Single-Molecule FRET Measurements of Catalytically Active Protein Disulfide Isomerase.
Mathivanan Chinnaraj, David A Barrios, Carl Frieden, Tomasz Heyduk, Robert Flaumenhaft

Chembiochem· January 2021

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Functional insights from biophysical study of TREM2 interactions with apoE and Aβ.
Daniel L Kober, Melissa D Stuchell-Brereton, Colin E Kluender, Hunter B Dean, Michael R Strickland, Carl Frieden

Alzheimers Dement· October 2020

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F NMR reveals the conformational properties of free thrombin and its zymogen precursor prethrombin-2.
Eliza A Ruben, Prafull S Gandhi, Zhiwei Chen, Sarah K Koester, Gregory T DeKoster, Carl Frieden

J Biol Chem· June 2020

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Charge Reduction of Membrane Proteins in Native Mass Spectrometry Using Alkali Metal Acetate Salts.
John T Petroff, Ailing Tong, Lawrence J Chen, Gregory T Dekoster, Farha Khan, Carl Frieden

Anal Chem· May 2020

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Native Mass Spectrometry, Ion Mobility, Electron-Capture Dissociation, and Modeling Provide Structural Information for Gas-Phase Apolipoprotein E Oligomers.
Hanliu Wang, Joseph Eschweiler, Weidong Cui, Hao Zhang, Carl Frieden

J Am Soc Mass Spectrom· May 2019

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Protein oligomerization as a metabolic control mechanism: Application to apoE.
Carl Frieden

Protein Sci· April 2019

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Structure-Function Analysis of the Curli Accessory Protein CsgE Defines Surfaces Essential for Coordinating Amyloid Fiber Formation.
Roger D Klein, Qin Shu, Zachary T Cusumano, Kanna Nagamatsu, Nathaniel C Gualberto, Carl Frieden

mBio· July 2018

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Peptide-Level Interactions between Proteins and Small-Molecule Drug Candidates by Two Hydrogen-Deuterium Exchange MS-Based Methods: The Example of Apolipoprotein E3.
Hanliu Wang, Don L Rempel, Daryl Giblin, Carl Frieden, Michael L Gross

Anal Chem· October 2017

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Understanding Curli Amyloid-Protein Aggregation by Hydrogen-Deuterium Exchange and Mass Spectrometry.
Hanliu Wang, Qin Shu, Don L Rempel, Carl Frieden, Michael L Gross

Int J Mass Spectrom· September 2017

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Deamidation Slows Curli Amyloid-Protein Aggregation.
Hanliu Wang, Qin Shu, Carl Frieden, Michael L Gross

Biochemistry· June 2017

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A mechanism for lipid binding to apoE and the role of intrinsically disordered regions coupled to domain-domain interactions.
Carl Frieden, Hanliu Wang, Chris M W Ho

Proc Natl Acad Sci U S A· June 2017

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Solution NMR structure of CsgE: Structural insights into a chaperone and regulator protein important for functional amyloid formation.
Qin Shu, Andrzej M Krezel, Zachary T Cusumano, Jerome S Pinkner, Roger Klein, Carl Frieden

Proc Natl Acad Sci U S A· June 2016

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ApoE: In Vitro Studies of a Small Molecule Effector.
Tridib Mondal, Hanliu Wang, Gregory T DeKoster, Berevan Baban, Michael L Gross, Carl Frieden

Biochemistry· May 2016

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Continuous and pulsed hydrogen-deuterium exchange and mass spectrometry characterize CsgE oligomerization.
Hanliu Wang, Qin Shu, Don L Rempel, Carl Frieden, Michael L Gross

Biochemistry· October 2015

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ApoE: the role of conserved residues in defining function.
Carl Frieden

Protein Sci· January 2015

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The binding of apolipoprotein E to oligomers and fibrils of amyloid-β alters the kinetics of amyloid aggregation.
Kanchan Garai, Philip B Verghese, Berevan Baban, David M Holtzman, Carl Frieden

Biochemistry· October 2014

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Concerning the structure of apoE.
Carl Frieden, Kanchan Garai

Protein Sci· December 2013

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Unmasking the roles of N- and C-terminal flanking sequences from exon 1 of huntingtin as modulators of polyglutamine aggregation.
Scott L Crick, Kiersten M Ruff, Kanchan Garai, Carl Frieden, Rohit V Pappu

Proc Natl Acad Sci U S A· December 2013

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ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions.
Philip B Verghese, Joseph M Castellano, Kanchan Garai, Yinong Wang, Hong Jiang, Carl Frieden

Proc Natl Acad Sci U S A· May 2013

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Quantitative analysis of the time course of Aβ oligomerization and subsequent growth steps using tetramethylrhodamine-labeled Aβ.
Kanchan Garai, Carl Frieden

Proc Natl Acad Sci U S A· February 2013

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Structural differences between apoE3 and apoE4 may be useful in developing therapeutic agents for Alzheimer's disease.
Carl Frieden, Kanchan Garai

Proc Natl Acad Sci U S A· June 2012

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The E. coli CsgB nucleator of curli assembles to β-sheet oligomers that alter the CsgA fibrillization mechanism.
Qin Shu, Scott L Crick, Jerome S Pinkner, Bradley Ford, Scott J Hultgren, Carl Frieden

Proc Natl Acad Sci U S A· April 2012

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Hydrogen/deuterium exchange and electron-transfer dissociation mass spectrometry determine the interface and dynamics of apolipoprotein E oligomerization.
Richard Y-C Huang, Kanchan Garai, Carl Frieden, Michael L Gross

Biochemistry· November 2011

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